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Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 14, 2006; 12(26): 4185-4190
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4185
Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma
Frédéric Di Fiore, Stéphane Lecleire, Olivier Rigal, Marie-Pierre Galais, Emmanuel Ben Soussan, Isabelle David, Bernard Paillot, Jacques-Henri Jacob, Pierre Michel
Frédéric Di Fiore, Stéphane Lecleire, Olivier Rigal, Emmanuel Ben Soussan, Bernard Paillot, Pierre Michel, Digestive Oncology Unit, Hepatogastroenterology Department, Rouen University Hospital, France
Marie-Pierre Galais, Jacques-Henri Jacob, Digestive Oncology unit, François Baclesse Centre, Caen, France
Isabelle David, Radiotherapy Department, Henri Becquerel Centre, Rouen, France
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Frédéric Di Fiore, Digestive Oncology Unit, Hepatogastroenterology Department, Rouen University Hospital- Charles Nicolle- France, 1, rue de Germont, 6031 Rouen Cedex, France. eliottdf@hotmail.com
Telephone: +33-2-32888101 Fax: +33-2-35151623
Received: January 25, 2006
Revised: April 10, 2006
Accepted: April 21, 2006
Published online: July 14, 2006

AIM: The aim of the study was to evaluate the predictive factors of survival in patients with locally advanced squamous cell esophageal carcinoma (LASCOC) treated with definitive chemoradiotherapy (CRT) regimen based on the 5FU/CDDP combination.

METHODS: All patients with LASCOC treated with a definitive CRT using the 5FU/CDDP combination between 1994 and 2000 were retrospectively included. Clinical complete response (CCR) to CRT was assessed by esophageal endoscopy and CT-scan 2 mo after CRT completion. Prognostic factors of survival were assessed using univariate and multivariate analysis by the Cox regression model.

RESULTS: A total of 116 patients were included in the study. A CCR to CRT was observed in 86/116 (74.1%). The median survival was 20 mo (range 2-114) and the 5-year survival was 9.4%. Median survival of responder patients to CRT was 25 mo (range 3-114) as compared to 9 mo (range 2-81) in non-responder patients (P < 0.001). In univariate analysis, survival was associated with CCR (P < 0.001), WHO performance status < 2 (P = 0.01), tumour length < 6 cm (P = 0.045) and weight loss < 10% was in limit of significance (P = 0.053). In multivariate analysis, survival was dependant to CCR (P < 0.0001), weight loss < 10% (P = 0.034) and WHO performance < 2 (P = 0.046).

CONCLUSION: Our results suggest that survival in patients with LASCOC treated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

Keywords: Definitive chemoradiotherapy, Esophageal squamous cell carcinoma, Predictive factors