Inhibitory effect of Fuzheng Yiliuyin in combination with chemotherapeutics on human gastric carcinoma cell strain

doi:10.3748/wjg.v12.i25.4071

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2006; 12(25): 4071-4073
Published online Jul 7, 2006. doi: 10.3748/wjg.v12.i25.4071

Inhibitory effect of Fuzheng Yiliuyin in combination with chemotherapeutics on human gastric carcinoma cell strain

Yi Liu, Rui Wang, Gen-Quan Qiu, Ke-Jun Nan, Xi-Cai Sun

Yi Liu, Rui Wang, Gen-Quan Qiu, Xi-Cai Sun, Department of TCM, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Ke-Jun Nan, Department of Oncology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Author contributions: All authors contributed equally to the work.

Supported by TCM Administration Bureau of Shannxi Province, China, No. 199704

Correspondence to: Dr. Yi Liu, Department of TCM, First Hospital of Xi’an Jiaotong University, Jiankang Road 1#, Xi’an 710061, Shaanxi Province, China. liuyi.jiaotong@163.com

Telephone: +86-29-81987592 Fax: +86-29-85252812

Received: January 13, 2006
Revised: February 12, 2006
Accepted: February 18, 2006
Published online: July 7, 2006

Abstract

AIM: To study the inhibitory effects of Fuzheng Yiliuyin (Decoction for Suppressing Tumors by Strengthening the Body Resistance) in combination with chemotherapeutics on human gastric carcinoma cell strain.

METHODS: Fuzheng Yiliuyin (ZY) combined with various kinds of chemotherapeutics was put into two kinds of cultivated human gastric carcinoma cell strains, then its inhibitory effects on human gastric carcinoma cell strains were determind by the MTT method. Flow cytometer was used to assay the apoptosis rate, and the ultrastructure of gastric carcinoma cells was observed under transmission electron microscope.

RESULTS: Obvious apoptosis was seen in gastric carcinoma cells after treatment with ZY for 72 h. ZY and chemical drugs had synergistic inhibition effects on the cultivated gastric carcinoma cells, but the effects were different on various cell strains. The inhibitory effects of ZY could be strengthened by cytotoxic action and apoptosis. ZY combined with fluorouracil, etoposide and cisplatin (EFP) chemotherapeutics had better inhibitory effects on SGC-7901, while ZY combined with EFP or with DDP chemotherapeutics had better inhibitory effects than other drugs on MGC-803.

CONCLUSION: ZY induces apoptosis and inhibits the growth of gastric carcinoma cells. ZY has the synergistic function of chemotherapeutics.

Keywords: Human gastric carcinoma cell strain, Traditional Chinese medicine, Chemotherapeutics