Clinical Research
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 28, 2006; 12(24): 3866-3873
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3866
Efficacy of balloon-occluded retrograde transvenous obliteration, percutaneous transhepatic obliteration and combined techniques for the management of gastric fundal varices
Hirotaka Arai, Takehiko Abe, Hitoshi Takagi, Masatomo Mori
Hirotaka Arai, Takehiko Abe, Department of Gastroenterology, Maebashi Red Cross Hospital, 3-20-14 Asahi-cho, Maebashi 371-0014, Japan
Hitoshi Takagi, Masatomo Mori, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine (previously known as the First Department of Internal Medicine, Gunma University School of Medicine), Maebashi, Gunma 371-8511, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Hirotaka Arai, Department of Gastro-enterology, Maebashi Red Cross Hospital, 3-20-14 Asahi-cho, Maebashi 371-0014, Japan. h-arai0213@jcom.home.ne.jp
Telephone: +81-27-2244585 Fax: +81-27-2433380
Received: January 12, 2006
Revised: February 10, 2006
Accepted: February 20, 2006
Published online: June 28, 2006
Abstract

AIM: To evaluate the effect of three interventional treatments involving transvenous obliteration for the treatment of gastric varices, and to compare the efficacy and adverse effects of these methods.

METHODS: From 1995 to 2004, 93 patients with gastric fundal varices underwent interventional radiologic embolotherapy at our hospital. Of the 93 patients, 75 were treated with the balloon-occluded retrograde transvenous obliteration (BRTO) procedure; 8 were with the percutaneous transhepatic obliteration (PTO) procedure; and 10 were with the combined BRTO and PTO therapy. A follow-up evaluation examined the rates of survival, recurrence and rebleeding of the gastric varices, worsening of esophageal varices and complications in each group.

RESULTS: The BRTO, PTO, and combined therapy were technically successful in 81% (75/93), 44% (8/18), and 100% (10/10) patients, respectively. Recurrence of gastric varices was found in 3 patients in the BRTO group and in 3 patients in the PTO group. Rebleeding was observed in 1 patient in the BRTO group and in 1 patient in the PTO group. The 1- and 3-year survival rates were 98% and 87% in the patients without hepatocellular carcinoma (HCC) in the BRTO group, 100% and 100% in the PTO group, and 90% and 75% in the combined therapy group, respectively.

CONCLUSION: Combined BRTO and PTO therapy may rescue cases with uncontrollable gastric fundal varices that remained even after treatment with BRTO and/or PTO, though there were limitations of our study, including retrospective nature and discrepancy in sample size between the BRTO, PTO and combined therapy groups.

Keywords: Gastric varices; Balloon-occluded retrograde transvenous obliteration; Percutaneous transhepatic obliteration; Combined therapy