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World J Gastroenterol. Jun 14, 2006; 12(22): 3609-3611
Published online Jun 14, 2006. doi: 10.3748/wjg.v12.i22.3609
Expression of E-selectin, integrin β1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance
Jin-Jing Ke, Qin-Shu Shao, Zhi-Qiang Ling
Jin-Jing Ke, Qin-Shu Shao, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Zhi-Qiang Ling, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Science and Technology Key Project of Zhejiang Province, No. 2002c33015
Correspondence to: Dr. Jin-Jing Ke, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang Province, China. kejinjing@hotmail.com
Telephone: +86-571-88226336 Fax: +86-571-85239988
Received: September 30, 2005
Revised: November 5, 2005
Accepted: November 10, 2005
Published online: June 14, 2006
Abstract

AIM: To study the expression levels of E- selectin, integrin β1 and immunoglobulin supperfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma.

METHODS: The serum contents of E-selectin, integrin β1 and ICAM-1 were detected by enzyme-linked immunosorbent assay (ELISA), in 47 healthy individuals (control group) and in 57 patients with gastric carcinoma (gastric carcinoma group) respectively prior to operation and 7 d after operation.

RESULTS: The serum E-selectin, ECAM-1 and integrin β1 were found to be expressed in both control and gastric carcinoma groups. However, they were highly expressed in patients with gastric carcinoma patients before operation or with unresectable tumours. The expression levels of ICAM-1 and integrin β1 were significantly higher in gastric carcinoma patients than in controls (P < 0.01). A comparison of the E-selectin levels between the two groups showed statistically insignificant difference (P = 0.64). In addition, the expression levels were all decreased substantially in the postoperative patients subjected to radical resection of the tumours, indicating that the high level expressions of these compounds might be the important factor for predicting the prognosis of these patients.

CONCLUSION: Serum E-selectin, ICAM-1 and integrin β1 expression levels are probably related to the metastasis and relapse of gastric cancer.

Keywords: Human gastric carcinoma cells; E-selectin; Integrin β1; ICAM-1; ELISA