Yamamoto-Furusho JK, Takahashi-Monroy T, Vergara-Fernandez O, Reyes E, Uscanga L. Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution. World J Gastroenterol 2006; 12(21): 3406-3409 [PMID: 16733859 DOI: 10.3748/wjg.v12.i21.3406]
Corresponding Author of This Article
Dr. Luis Uscanga, Chief of Postgraduate Medical Education, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga 15, Colonia Seccion XVI, Delegacion Tlalpan C.P. 14000, Mexico City,Mexico. uscanga@quetzal.innsz.mx
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Jun 7, 2006; 12(21): 3406-3409 Published online Jun 7, 2006. doi: 10.3748/wjg.v12.i21.3406
Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution
Jesus K Yamamoto-Furusho, Takeshi Takahashi-Monroy, Omar Vergara-Fernandez, Edgardo Reyes, Luis Uscanga
Jesus K Yamamoto-Furusho, Luis Uscanga, Departments of Gastroenterology. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Takeshi Takahashi-Monroy, Omar Vergara-Fernandez, Departments of Surgery. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Edgardo Reyes, Departments of Pathology. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Supported by the “Consejo Nacional de Ciencia y Tecnología (CONACYT)”, Mexico
Correspondence to: Dr. Luis Uscanga, Chief of Postgraduate Medical Education, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga 15, Colonia Seccion XVI, Delegacion Tlalpan C.P. 14000, Mexico City,Mexico. uscanga@quetzal.innsz.mx
Telephone: +52-55-55732184 Fax: +52-55-56551076
Received: August 20, 2005 Revised: August 28, 2005 Accepted: October 10, 2005 Published online: June 7, 2006
Abstract
AIM: To assess the prevalence and clinical value of p-ANCA in a sample of Mexican ulcerative colitis (UC) patients.
METHODS: In a prospective, IRB-approved protocol, p-ANCA was determined in 80 patients with UC (mean age, 32 ± 12.9 years). The severity and extension of disease were determined by clinical methods, searching a statistical association with p-ANCA status.
RESULTS: p-ANCA were detected in 41 (51%) patients. Severity of disease was the only clinical variable statistically associated with their presence (P < 0.0001; OR = 9; CI 95% = 3.2-24.7).
CONCLUSION: The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.
