Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H+ and HCO3- secretion in rats

doi:10.3748/wjg.v12.i20.3271

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May 28, 2006 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2006; 12(20): 3271-3274
Published online May 28, 2006. doi: 10.3748/wjg.v12.i20.3271

Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H⁺ and HCO₃^- secretion in rats

Xue-Ying Zhang, Hong-Bin Ai, Xi-Yun Cui

Xue-Ying Zhang, Hong-Bin Ai, Xi-Yun Cui, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China

Author contributions: All authors contributed equally to the work.

Supported by Science Foundation of Shandong Province, No. Y2002D18

Correspondence to: Hong-Bin Ai, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China. physiology@sdnu.edu.cn

Telephone: +86-531-86185359

Received: August 8, 2005
Revised: October 20, 2005
Accepted: October 26, 2005
Published online: May 28, 2006

Abstract

AIM: To determine the effects of electrical stimulation of nucleus ambiguus (NA) and dorsal motor nuclei of vagus (DMV) on gastric acid and bicarbonate secretion in rats.

METHODS: NA and DMV in rats were electrically stimulated. Pylorus ligation or esophagus perfusion was used to collect the gastric secretion. The titratable H⁺ quantum, H⁺ concentration, HCO₃^- secretion quantum were measured.

RESULTS: Electrical stimulation of NA had no effects on the volume of gastric juice, titratable acidity and acid concentration, but elicited a pronounced increase in the total bicarbonate. However, electrical stimulation of DMV significantly increased the titratable acidity, the volume of gastric juice and the acid concentration. Similarly, electrical stimulation of either NA or DMV decreased the respiratory frequency and sinus bradycardia.

CONCLUSION: NA in rats can not control the secretion of gastric acid but the secretion of bicarbonate in gastric juice, while DMV controls the secretion of gastric acid.

Keywords: Rat, Nucleus ambiguus, Dorsal motor nuclei of vagus, Gastric acid, Gastric bicarbonate