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World J Gastroenterol. May 21, 2006; 12(19): 3105-3107
Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.3105
Efficacy of one-day quadruple therapy for H pylori infection in Chinese patients
Xiao-Hui Huo, Jian-Kun Chu, Xiu-Fen Yang, Jing Wang, Li-Jing Zhang, Jin-Cheng Ma, Jun Yu
Xiao-Hui Huo, Jian-Kun Chu, Xiu-Fen Yang, Jing Wang, Li-Jing Zhang, Jin-Cheng Ma, Jun Yu, Department of Gastroenterology, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
Jun Yu, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
Author contributions: All authors contributed equally to the work
Supported by the National Natural Science Foundation of China to Dr Jun Yu, No. 30370637
Correspondence to: Dr Jun Yu, Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, NT, Hong Kong, China. junyu@cuhk.edu.hk
Telephone: +852-26-321195 Fax: +852-26-321194
Received: January 23, 2006
Revised: February 14, 2006
Accepted: February 18, 2006
Published online: May 21, 2006
Abstract

AIM: To compare the efficacies of one-day quadruple therapy and seven-day triple therapy in Chinese patients.

METHODS: Sixty consecutive patients with nonulcer dyspepsia and confirmed H pylori infection were randomized to receive either omeprazole 40 mg, amoxycillin 1 g, and furazolidone 100 mg, all twice a day for 7 d or omeprazole 20 mg (at breakfast and dinner), amoxicillin 1 g, furazolidone 200 mg, and colloidal bismuth subcitrate 220 mg four times for only one day. H pylori status was determined before and at least 5 weeks after therapy by endoscopy with antral and corpus biopsies for rapid urease test and histology.

RESULTS: H pylori eradication was successful in 66.67% (20/30) patients in the 7-d group and in 36.67% (11/30) patients in the 1-day group (P = 0.037). Side effects were induced by the treatment in 13.3% (4/30) patients of each group, but these were all self-limiting, short-lasting, and did not require any specific treatment.

CONCLUSION: The one-day quadruple therapy is less effective than the one-week regimen in curing H pylori infection in Chinese patients.

Keywords: H pylori; Quadruple therapy; Antibiotics; Gastritis; Side effects