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World J Gastroenterol. May 21, 2006; 12(19): 2991-2999
Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.2991
Helicobacter pylori infection causes gastric cancer A? review of the epidemiological, meta-analytic, and experimental evidence
Guy D Eslick
Guy D Eslick, School of Public Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
Correspondence to: Dr. Guy D Eslick, Department of Medicine, The University of Sydney, Nepean Hospital, Level 5, South Block, PO Box 63, Penrith, NSW 2751, Australia.
Telephone: +61-2-47343726 Fax: +61-2-47342614
Received: December 22, 2005
Revised: January 8, 2006
Accepted: January 14, 2006
Published online: May 21, 2006

Since the discovery of Campylobacter-like organisms Helicobacter pylori (H pylori) more than two decades ago the possibility of a relationship with gastric cancer has been postulated, tested and supposedly proven. There have been numerous human studies of various designs from many countries around the world. Several meta-analyses have been published and more recently a small number of experimental animal studies were reported looking at the association between H pylori infection and gastric cancer. Over the years, the human epidemiological studies have produced conflicting results; the meta-analyses have as one would expect produced similar pooled estimates; while the early experimental animal studies require replication. The exact mechanisms by which H pylori might cause gastric cancer are still under investigation and remain to be elucidated.

Keywords: Helicobacter pylori, Gastric cancer, Meta-analysis, Systematic review