Choi SJ, Kim YS, Chae JR, Cho HK, Kim TH, Sohn YW, Oh YL, Seo GS, Nah YH, Choi SC. Effects of ranitidine for exercise induced gastric mucosal changes and bleeding. World J Gastroenterol 2006; 12(16): 2579-2583 [PMID: 16688805 DOI: 10.3748/wjg.v12.i16.2579]
Corresponding Author of This Article
Dr. Suck Chei Choi, Department of Internal Medicine, School of Medicine, Wonkwang University and Digestive Disease Research Institute, Iksan, South Korea. medcsc@wmc.wonkwang.ac.kr
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Rapid Communication
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World J Gastroenterol. Apr 28, 2006; 12(16): 2579-2583 Published online Apr 28, 2006. doi: 10.3748/wjg.v12.i16.2579
Effects of ranitidine for exercise induced gastric mucosal changes and bleeding
Suck Jun Choi, Yong Sung Kim, Jeong Ryong Chae, Hong Kwan Cho, Tae Hyeon Kim, Young Woo Sohn, Yong Leol Oh, Geom Seog Seo, Yong-Ho Nah, Suck Chei Choi
Suck Jun Choi, Department of Leisure and Sports, Wonkwang Health Science College, Iksan, South Korea
Yong Sung Kim, Tae Hyeon Kim, Young Woo Sohn, Yong Leol Oh, Geom Seog Seo, Yong-Ho Nah, Department of Internal Medicine, School of Medicine, Wonkwang University and Digestive Disease Research Institute, Iksan, South Korea
Jeong Ryong Chae, Hong Kwan Cho, Department of Physical Education, College of Natural Sciences, Kunsan National University, Kunsan, South Korea
Suck Chei Choi, Department of Internal Medicine, School of Medicine, Wonkwang University and Digestive Disease Research Institute, Iksan, South Korea and Department of Physical Education, College of Natural Sciences, Kunsan National University, Kunsan, South Korea
Co-first-authors: SJ Choi and YS Kim
Supported by the 2005 research fund of Wonkwang University
Correspondence to: Dr. Suck Chei Choi, Department of Internal Medicine, School of Medicine, Wonkwang University and Digestive Disease Research Institute, Iksan, South Korea. medcsc@wmc.wonkwang.ac.kr
Telephone: +82-63-8501075 Fax: +82-63-8547675
Received: November 28, 2005 Revised: January 4, 2006 Accepted: January 14, 2006 Published online: April 28, 2006
Abstract
AIM: To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runners.
METHODS: Twenty-four long distance runners (M: 16, F: 8, age: 18.2 ± 1.5 years) participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal (GI) endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine (150 mg, b.i.d.) for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment.
RESULTS: Twenty-two of the 24 runners had at least one upper GI mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heme occult positive prior to the study, but only one was positive after the medication.
CONCLUSION: Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acid-related factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding.
