Clinical Research
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 28, 2006; 12(16): 2556-2562
Published online Apr 28, 2006. doi: 10.3748/wjg.v12.i16.2556
Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation
Giovanni Gasbarrini, Marcello Candelli, Riccardo Giuseppe Graziosetto, Sergio Coccheri, Ferdinando Di Iorio, Giuseppe Nappi
Giovanni Gasbarrini, Marcello Candelli, Riccardo Giuseppe Graziosetto, Department of Internal Medicine, Catholic University of Rome, Italy
Sergio Coccheri, Department of Angiology, University of Bologna, Italy
Ferdinando Di Iorio, Department of Biomedical Sciences and Technologies, University of L'Aquila
Giuseppe Nappi, Department of Thermal Medicine, University of Milan, italy
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Giovanni Gasbarrini, MD, Department of Internal Medicine, Catholic University, Gemelli Hospital, Largo A Gemelli 800135, Roma,
Telephone: +39-06-30155394 Fax: +39-06-35502775
Received: June 1, 2005
Revised: July 2, 2005
Accepted: July 8, 2005
Published online: April 28, 2006

AIM: To evaluate the efficacy of water supplementation treatment in patients with functional dyspepsia or irritable bowe syndrome (IBS) accompanying predominant constipation.

METHODS: A total of 3 872 patients with functional dyspepsia and 3 609 patients with irritable bowel syndrome were enrolled in the study by 18 Italina thermal centres. Patients underwent a first cycle of thermal therapy for 21 d. A year later patients were re-evaluated at the same centre and received another cycle of thermal therapy. A questionnare to collect personal data on social and

occupational status, family and pathological case history, life style, clinical records, utilisation of welfare and health structure and devices was administered to each patient at basal time and one year after each thermal treatment. Sixty patients with functional dyspepsia and 20 with IBS and 80 healthy controls received an evaluation of gastric output and oro-cecal transit time by breath test analysis. Breath test was performed at basal time and after water supplementaton therapies. Gastrointestinal symptoms were evaluated at the same time points. Breath samples were analyzed with a mass spectometer and a gascromatograph. Results were expressed as T1/2 and T-lag for octanoic acid breath test and as oro-cecal transit time for lactulose breath test.

RESULTS: A significant reduction of prevalence of symptoms was observed at the end of the first and second cycles of thermal therapy in dyspeptic and IBS patients. The analysis of variance showed a real and persistant improvement of symptoms in all patients. After water supplementation for 3 wk a reduction of gastric output was observed in 49 (87.5%) of 56 dyspeptic patients. Both T1/2 and T-lag were significantly reduced after the therapy compared to basal values [91 ± 12 (T1/2) and 53 ± 11 (T-lag), Tables 1 and 2] with results of octanoic acid breath test similar to healthy subjects. After water supplementation for 3 wk oro-cecal transit time was shorter than that at the beginning of the study.

CONCLUSION: Mineral water supplementation treatment for functional dyspepsia or conspipation accompanying IBS can improve gastric acid output and intestinal transit time.

Keywords: Mineral water, Constipation, Dispepsia, Thermal therapy