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World J Gastroenterol. Apr 21, 2006; 12(15): 2398-2401
Published online Apr 21, 2006. doi: 10.3748/wjg.v12.i15.2398
Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey
Giorgio Nervi, Stefania Liatopoulou, Lucas Giovanni Cavallaro, Alessandro Gnocchi, Nadia Dal Bò, Massimo Rugge, Veronica Iori, Giulia Martina Cavestro, Marta Maino, Giancarlo Colla, Angelo Franzè, Francesco Di Mario
Giorgio Nervi, Alessandro Gnocchi, Giancarlo Colla, Angelo Franzè, Gastroenterology Unit, Parma, Italy
Stefania Liatopoulou, Lucas Giovanni Cavallaro, Veronica Iori, Giulia Martina Cavestro, Marta Maino, Francesco Di Mario, Department of Clinical Sciences, Chair of Gastroenterology, Parma, Italy
Nadia Dal Bò, Gastroenterology Unit, Treviso, Italy
Massimo Rugge, Institute of Pathology, University of Padova, Italy
Correspondence to: Francesco Di Mario, Dipartimento di Scienze Cliniche, Sezione di Gastroenterologia, Azienda Ospedaliera Universitaria di Parma, v. Gramsci 14, 43100 Parma, Italy. francesco.dimario@unipr.it
Telephone: +39-05-21991772 Fax: +39-05-21291582
Received: July 19, 2005
Revised: July 20, 2005
Accepted: August 26, 2005
Published online: April 21, 2006

AIM: To compare peptic ulcer prevalence in patients referred for upper gastrointestinal endoscopy in two Italian hospitals in pre-Helicobacter era and ten years after the progressive diffusion of eradication therapy.

METHODS: We checked all the endoscopic examinations consecutively performed in the Gastroenterology Unit of Padova during 1986-1987 and 1995-1996, and in the Gastroenterology Unit of Parma during 1992 and 2002. Chi Square test was used for statistic analysis.

RESULTS: Data from both the endoscopic centers showed a statistically significant decrease in the prevalence of ulcers: from 12.7% to 6.3% (P < 0.001) in Padova and from 15.6% to 12% (P < 0.001) in Parma. The decrease was significant both for duodenal (from 8.8% to 4.8%, P < 0.001) and gastric ulcer (3.9% to 1.5%, P < 0.001) in Padova, and only for duodenal ulcer in Parma (9.2% to 6.1%, P < 0.001; gastric ulcer: 6.3% to 5.8%, NS).

CONCLUSION: Ten years of extensive Helicobacter pylori (H pylori) eradication in symptomatic patients led to a significant reduction in peptic ulcer prevalence. This reduction was particularly evident in Padova, where a project for the sensibilization of H pylori eradication among general practioners was carried out between 1990 and 1992. Should our hypothesis be true, H pylori eradication might in the future lead to peptic ulcer as a rare endoscopic finding.

Keywords: Ulcer prevalence, H pylori