Published online Apr 14, 2006. doi: 10.3748/wjg.v12.i14.2288
Revised: October 10, 2005
Accepted: November 18, 2005
Published online: April 14, 2006
AIM: To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.
METHODS: Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.
RESULTS: The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp- group (group B), the duodenal ulcer Hp + group (group C), duodenal ulcer Hp- group (group D), and normal control group (group E) were 28.50 + 4.55, 19.60 + 2.49, 22.69 + 2.71, 25.33 + 4.76, and 18.80 + 2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47 + 1.44, 17.29 + 2.04, 15.30 + 1.38, 13.11 + 0.93 and 12.14 + 1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant.
CONCLUSION: The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.