Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take &ldquo;toll&rdquo;

doi:10.3748/wjg.v12.i12.1829

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Mar 28, 2006 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2006; 12(12): 1829-1841
Published online Mar 28, 2006. doi: 10.3748/wjg.v12.i12.1829

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take “toll”

Peter Laszlo Lakatos, Simon Fischer, Laszlo Lakatos, Istvan Gal, Janos Papp

Peter Laszlo Lakatos, Simon Fischer, Janos Papp, 1^st Department of Medicine, Semmelweis University, Budapest, Hungary

Laszlo Lakatos, 1^st Department of Medicine, Csolnoky F. County Hospital, Veszprem, Hungary

Istvan Gal, 2^nd Department of Medicine, Kenezi Gy. County Hospital, Debrecen, Hungary

Correspondence to: Peter Laszlo Lakatos, MD, PhD, 1^st Department of Medicine, Semmelweis University, Koranyi str. 2/A, H-1083 Hungary. kislakpet@bell.sote.hu

Telephone: +36-1-2100278-1500 Fax: +36-1-3130250

Received: October 6, 2005
Revised: October 20, 2005
Accepted: November 10, 2005
Published online: March 28, 2006

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis (UC) or Crohn’s disease (CD) or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors (e.g. NOD2/CARD15, SLC22A46A5 and DLG5). The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.

Keywords: Inflammatory bowel disease, Ulcerative colitis, Crohn’s disease, Pathogenesis, Microbial factors, Genetics, NOD2/CARD15, SLC22A4/A5, DLG5