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World J Gastroenterol. Mar 21, 2006; 12(11): 1770-1773
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1770
Effect of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori: A randomized, controlled trial
Feng Ji, Zi-Wei Wang, Jian-Wen Ning, Qun-Yan Wang, Jian-Yong Chen, You-Ming Li
Feng Ji, Zi-Wei Wang, Jian-Wen Ning, Qun-Yan Wang, You-Ming Li, First Affiliated Hospital, Medicine School of Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Jian-Yong Chen, Red Cross Hospital, Hangzhou 310029, Zhejiang Province, China
Correspondence to: Dr. Feng Ji, First Affiliated Hospital, Medicine School of Zhejiang University, Hangzhou 310003, Zhejiang Province, China. jifeng1126@sina.com
Telephone: +86-571-87236568
Received: July 18, 2005
Revised: July 25, 2005
Accepted: August 20, 2005
Published online: March 21, 2006
Abstract

AIM: To study the effects of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori (H pylori).

METHODS: Forty-eight patients with hyperplastic gastric polyps (3-10 mm in diameter) infected with H pylori were randomly assigned to a treatment group (n = 24) which received proton-pump inhibitor (omeprazole or lansoprazole), clarithromycin, bismuth citrate and tinidazole, and a control group (n = 24) which received protective agent of gastric mucosa(tepretone). Patients underwent endoscopy and H pylori examination regularly before enrollment and 1-12 mo after treatment.

RESULTS: Twenty-two patients in the treatment group and 21 in the control group completed the entire test protocol. In the treatment group, polyps disappeared 1-12 mo (average, 6.5 ± 1.1 mo) after the treatment in 15 of 22 patients (68.2%) and H pylori infection was eradicated in 19 of the 22 patients (86.4%). However, 12 months after the study, no change in polyps or H pylori status was seen in any controls (bP < 0.01).

CONCLUSION: Most hyperplastic gastric polyps disappear after eradication of H pylori.

Keywords: Helicobacter pylori; Hyperplastic gastric polyps; Therapy