Bani-Hani KE, Bani-Hani BK. Pathogenesis of columnar-lined esophagus. World J Gastroenterol 2006; 12(10): 1521-1528 [PMID: 16570343 DOI: 10.3748/wjg.v12.i10.1521]
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Kamal E Bani-Hani, Professor of Surgery, Chairman of Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. firstname.lastname@example.org
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Kamal E Bani-Hani, Bayan K Bani-Hani, Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Author contributions: All authors contributed equally to the work.
Correspondence to: Kamal E Bani-Hani, Professor of Surgery, Chairman of Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. email@example.com
Telephone: +962-2-7060200 Fax: +962-2-7095010
Received: July 17, 2005 Revised: September 12, 2005 Accepted: October 10, 2005 Published online: March 14, 2006
Since its initial description, the pathogenesis of the columnar-lined esophagus (CLE) has been surrounded by many controversies. The first controversy is related to the existence of the condition itself. The second controversy centers on whether the CLE is a congenital or an acquired condition. In this article, we review the congenital and acquired theories of development of CLE and discuss the various factors in acquisition of CLE. The bulk of evidence in the literature suggests that CLE is an acquired condition.