Tong DY, Wang XH, Xu CF, Yang YZ, Xiong SD. Hepatitis B virus infection and coronary atherosclerosis: Results from a population with relatively high prevalence of hepatitis B virus. World J Gastroenterol 2005; 11(9): 1292-1296 [PMID: 15761966 DOI: 10.3748/wjg.v11.i9.1292]
Corresponding Author of This Article
Dr. Si-Dong Xiong, Department of Immunology, Shanghai Medical College of Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. sdxiongfd@126.com
Article-Type of This Article
Viral Hepatitis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
De-Yan Tong, Xiao-Hua Wang, Si-Dong Xiong, Department of Immunology, Shanghai Medical College of Fudan University, Center for Gene Immunization and Vaccine Research (Shanghai), Shanghai 200032, China
Cong-Feng Xu, Ying-Zhen Yang, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: All authors contributed equally to the work.
Supported by Major State Basic Research Development Program of China, No. G2000056903 and the National High Technology Research and Development Program of China, No. 2004AA215242
Correspondence to: Dr. Si-Dong Xiong, Department of Immunology, Shanghai Medical College of Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. sdxiongfd@126.com
Telephone: +86-21-54237749 Fax: +86-21-54237749
Received: September 5, 2004 Revised: September 8, 2004 Accepted: October 8, 2004 Published online: March 7, 2005
Abstract
AIM: To investigate the possible association between hepatitis B virus (HBV) infection and angiographically proven coronary artery disease (CAD) in a population with relatively high prevalence of HBV.
METHODS: Sera from 434 patients who underwent coronary angiography were tested for HBV antigens (HBsAg, HBeAg) and antibodies (Anti-HBs, Anti-HBc and Anti-HBe) by ELISA.
RESULTS: Seventy-seven percent (224/291) of the patients with CAD and 73.4% (105/143) of the patients without angiographic evidence of atherosclerosis were seropositive for HBV (P>0.05). However, C-reactive protein (CRP) levels were significantly higher in patients with CAD (P = 0.008), while lower in HBV seropositive population (P = 0.043 and P = 0.021 after adjustment for conventional risk factors).
CONCLUSION: Our results suggested HBV infection negatively correlates with CRP levels, but seems not to be associated with coronary atherosclerosis.
