Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma

doi:10.3748/wjg.v11.i48.7666

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 28, 2005; 11(48): 7666-7670
Published online Dec 28, 2005. doi: 10.3748/wjg.v11.i48.7666

Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma

Liang Zhao, Zhi-Xiang Shen, He-Sheng Luo, Lei Shen

Liang Zhao, Zhi-Xiang Shen, He-Sheng Luo, Lei Shen, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Liang Zhao, MD, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China. airman-zhao@tom.com

Telephone: +86-27-88041919-2135

Received: January 31, 2005
Revised: April 2, 2005
Accepted: April 11, 2005
Published online: December 28, 2005

Abstract

AIM: To investigate the expression of leptin and leptin receptor (ob-R) in intestinal-type gastric cancer and precancerous lesions, and to explore the possible mechanism and role of the leptin system in developing intestinal-type gastric adenocarcinoma.

METHODS: Immunohistochemistry was performed to examine the expression of leptin and leptin receptor in archival samples of gastric adenocarcinoma and preneoplastic lesions, including intestinal metaplasia and mild to severe gastric epithelial dysplasia. Positive staining was identified and percentage of positive staining was graded.

RESULTS: Dual expression of leptin and leptin receptor were detected in 80% (16/20) intestinal metaplasia, 86.3% (25/30) mild gastric epithelial dysplasia, 86.7% (26/30) moderate gastric epithelial dysplasia, 93.3% (28/30) severe gastric epithelial dysplasia, 91.3% (55/60) intestinal-type gastric adenocarcinoma and 30.0% (9/30) diffuse-type gastric carcinoma. The percentage of dual expression of leptin and leptin receptor in intestinal-type gastric adenocarcinoma was significantly higher than that in diffuse-type gastric adenocarcinoma (χ² = 37.022, P<0.01).

CONCLUSION: Our results indicate the presence of an autocrine loop of leptin system in the development of intestinal-type gastric adenocarcinoma.

Keywords: Leptin, Leptin receptor (ob-R), Intestinal-type gastric adenocarcinoma, Intestinal metaplasia, Gastric epithelial dysplasia