Case Report
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2005; 11(44): 7051-7053
Published online Nov 28, 2005. doi: 10.3748/wjg.v11.i44.7051
Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor
Ozdal Ersoy
Ozdal Ersoy, Sisili Etfal Education and Research Hospital, Kocamancur sok, Sisili
Author contributions: All authors contributed equally to the work.
Correspondence to: Ozdal Ersoy, Sisili Etfal Education and Research Hospital, Kocamancur sok 16/6 80240, Sisili.
Telephone: +90-2122413741
Received: December 16, 2004
Revised: January 2, 2005
Accepted: January 5, 2005
Published online: November 28, 2005

Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor[7]. HCC is one of the most common malignancies worldwide and the incidence of HCC increases with age[8]. The relationship between hepatitis B incidence and HCC rates is also well recognized. Alpha fetoprotein (AFP) is produced by 70% of HCC. Though a level of AFP >400 ng/mL is diagnostic for HCC, in the presence of active hepatitis B infection, the cut-off level should be considered to be at least 1 000-4 000 ng/mL. Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP[10]. Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.

Keywords: Hepatocellular carcinoma, Sertoli-Leydig cell tumor, AFP, Cirrhosis, Hypercholesterolemia