Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2005; 11(39): 6208-6211
Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6208
Microcirculation disturbance affects rats with acute severe pancreatitis following lung injury
Xue-Min Liu, Qing-Guang Liu, Jun Xu, Cheng-En Pan
Xue-Min Liu, Qing-Guang Liu, Jun Xu, Cheng-En Pan, Department of Hepatobiliary Surgery, Xi’an Jiaotong University First Hospital, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30371398
Correspondence to: Dr. Xue-Min Liu, Department of Hepatobiliary Surgery, Xi’an Jiaotong University First Hospital, Xi’an 710061, Shaanxi Province, China. a1090224@pub.xaonline.com
Telephone: +86-29-85324009|
Received: February 21, 2004
Revised: April 2, 2005
Accepted: April 5, 2005
Published online: October 21, 2005
Abstract

AIM: To study the effects of microcirculation disturbance (MD) on rats with acute severe pancreatitis (ASP).

METHODS: We developed ASP rat models, and anatomized separately after 1, 3, 5, 7, and 9 h. We took out blood and did hemorrheologic examination and erythrocyte osmotic fragility test, checked up the water content, capillary permeability, and genetic expression of intercellular adhesion molecule-1 (ICAM-1) in lung tissues, examined the apoptosis degree of blood vessel endothelium while we tested related gene expression of Bax and Bcl-2 in lung tissues. We did the same examination in control group.

RESULTS: The viscosity of total blood and plasma, the hematocrit, and the erythrocyte osmotic fragility were all increased. Fibrinogen was decreased. The water content in lung tissues and capillary permeability were increased. Apoptosis degree of blood vessel endothelium was increased too. ICAM-1 genetic expression moved up after 1 h and reached its peak value after 9 h.

CONCLUSION: MD plays an important role in ASP following acute lung injury (ALI). The functional damage of blood vessel endothelium, the apoptosis of capillary vessel endothelium, WBC edging-concentration and the increasing of erythrocyte fragility are the main reasons of ALI.

Keywords: Microcirculation; Acute pancreatitis; Lung injury