Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2005; 11(36): 5732-5734
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5732
Role of perioperative parenteral nutrition in severely malnourished patients with Crohn’s disease
Guo-Xiang Yao, Xiu-Rong Wang, Zhu-Ming Jiang, Si-Yuang Zhang, An-Ping Ni
Guo-Xiang Yao, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Xiu-Rong Wang, Zhu-Ming Jiang, Si-Yuang Zhang, An-Ping Ni, Department of Surgery, Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Guo-Xiang Yao, MD, Department of Surgery (New Surg Bld-14 F), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Grand Road, Hankou, Wuhan 430030, Hubei Province, China. gxyao@tjh.tjmu.edu.cn Telephone: +86-27-61048672
Received: February 15, 2005
Revised: April 8, 2005
Accepted: April 11, 2005
Published online: September 28, 2005
Abstract

AIM: To evaluate the effect of perioperative parenteral nutrition on serum immunoglobulin, weight change, and post-operative outcome in severely malnourished patients with Crohn’s disease.

METHODS: Thirty-two severely malnourished patients with Crohn’s disease who had undergone surgery in our hospital were reviewed. Sixteen patients who received perioperative parenteral nutrition were enrolled in the study group, and the other 16 patients who did not receive parenteral nutrition were enrolled in the control group. Serum immunoglobulin, body mass index (BMI), liver function, weight change, and postoperative complications were evaluated.

RESULTS: Serum IgM levels elevated 1 wk before surgery in both groups, and decreased to normal value (from 139 ± 41 to 105 ± 29 mg/dL, P = 0.04) 4 wk after operation in the study group, while no significant changes was noted in the control group (from 133 ± 16 to 129 ± 13 mg/dL, P = 0.34). There were no significant changes in concentrations of IgG and IgA. The BMI of the study group increased from 13.9 ± 0.6 to 15.3 ± 0.7 kg/m2 (P = 0.02) with no significant change in the control group (14.1 ± 0.7 and 14.5 ± 0.5, respectively, P = 0.81). The percentage of resuming work was higher in the study group than in the control group.

CONCLUSION: Perioperative parenteral nutrition possibly ameliorates the humoral immunity, reverses malnutrition, and facilitates rehabilitation.

Keywords: Parenteral nutrition; Malnourished patients; Crohn’s disease