Effects of acupuncturing Tsusanli (ST36) on expression of nitric oxide synthase in hypothalamus and adrenal gland in rats with cold stress ulcer

doi:10.3748/wjg.v11.i32.4962

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Aug 28, 2005 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2005; 11(32): 4962-4966
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.4962

Effects of acupuncturing Tsusanli (S_T36) on expression of nitric oxide synthase in hypothalamus and adrenal gland in rats with cold stress ulcer

Jin-Ping Sun, Hai-Tao Pei, Xiang-Lan Jin, Ling Yin, Qing-Hua Tian, Shu-Jun Tian

Jin-Ping Sun, Hai-Tao Pei, Emergency Neurology Department, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China

Xiang-Lan Jin, Ling Yin, Qing-Hua Tian, Shu-Jun Tian, Center of Neuroinformatics, General Hospital of PLA, Beijing 100853, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30171135

Correspondence to: Dr. Ling Yin, No.28 Fuxing Road, Center of Neuroinformatics, General Hospital of PLA, Beijing 100853, China. sunjinping@sina.com

Telephone: +86-10-66937546

Received: November 20, 2004
Revised: January 23, 2005
Accepted: January 26, 2005
Published online: August 28, 2005

Abstract

AIM: To study the protective effect of acupuncturing Tsusanli (S_T36) on cold stress ulcer, and the expression of nitric oxide synthase (NOS) in hypothalamus and adrenal gland.

METHODS: Ulcer index in rats and RT-PCR were used to study the protective effect of acupuncture on cold stress ulcer, and the expression of NOS in hypothalamus and adrenal gland. Images were analyzed with semi-quantitative method.

RESULTS: The ulcer index significantly decreased in rats with stress ulcer. Plasma cortisol concentration was up regulated during cold stress, which could be depressed by pre-acupuncture. The expression of NOS1 in hypothalamus increased after acupuncture. The increased expression of NOS2 was related with stress ulcer, which could be decreased by acupuncture. The expression of NOS3 in hypothalamus was similar to NOS2, but the effect of acupuncture was limited. The expression of NOS2 and NOS3 in adrenal gland increased after cold stress, only the expression of NOS1 could be repressed with acupuncture. There was no NOS2 expression in adrenal gland in rats with stress ulcer.

CONCLUSION: The protective effect of acupuncturing Tsusanli (S_T36) on the expression of NOS in hypothalamus and adrenal gland can be achieved.

Keywords: Acupuncture, Cold stress, Ulcer, Rats, NOS