Direct measurement of gastric H+/K+-ATPase activities in patients with or without Helicobacter pylori-associated chronic gastritis

doi:10.3748/wjg.v11.i23.3514

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Helicobacter Pylori

World J Gastroenterol. Jun 21, 2005; 11(23): 3514-3517
Published online Jun 21, 2005. doi: 10.3748/wjg.v11.i23.3514

Direct measurement of gastric H⁺/K⁺-ATPase activities in patients with or without Helicobacter pylori-associated chronic gastritis

Duangporn Thong-Ngam, Pisit Tangkijvanich, Pichet Sampatanukul, Paungpayom Prichakas, Varocha Mahachai, Piyaratana Tosukowong

Duangporn Thong-Ngam, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Pisit Tangkijvanich, Piyaratana Tosukowong, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Pichet Sampatanukul, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Paungpayom Prichakas, Department of Nuclear Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Varocha Mahachai, Department of Medicine, Chulalongkorn University Hospital, Bangkok 10330, Thailand

Author contributions: All authors contributed equally to the work.

Correspondence to: Duangporn Thong-Ngam, Department of Physiology, Chulalongkorn University Hospital, Bangkok 10330, Thailand. d.thong@mailcity.com

Received: December 11, 2003
Revised: December 12, 2003
Accepted: January 29, 2004
Published online: June 21, 2005

Abstract

AIM: The role of Helicobacter pylori (H pylori ) infection in gastric acid secretion of patients with chronic gastritis remains controversial. This study was designed to elucidate the effect of H pylori on H⁺/K⁺-ATPase activities in gastric biopsy specimens.

METHODS: Eighty-two patients with chronic gastritis who had undergone upper endoscopy were included in this study. H pylori infection was confirmed by rapid urease test and histology. Gastric H⁺/K⁺-ATPase activities and serum gastrin concentrations were measured by an enzymatic method and radioimmunoassay, respectively. For those patients who received triple therapy for eradicating H pylori, changes in the activity of gastric H⁺/K⁺-ATPase and serum gastrin levels were also measured.

RESULTS: The mean gastric H⁺/K⁺-ATPase activity in H pylori-positive group (42 patients) was slightly higher than that in H pylori-negative group (29 patients) (169.65±52.9 and 161.38±43.85 nmol P_i/(mg·h), respectively, P = 0.301). After eradication of H pylori, the gastric H⁺/K⁺-ATPase activities slightly decreased compared to prior therapy (165.03±59.50 and 158.42±38.93 nmol P_i/(mg·h), respectively, P = 0.805). The mean basal gastrin concentration was slightly higher in H pylori-positive patients than in H pylori-negative patients (87.92±39.65 pg/mL vs 75.04± 42.57 pg/mL, P = 0.228). The gastrin levels fell significantly after the eradication of H pylori. (Before treatment 87.00±30.78 pg/mL, after treatment 64.73±18.96 pg/mL, P = 0.015).

CONCLUSION: Gastric H⁺/K⁺-ATPase activities are not associated with H pylori status in patients with chronic gastritis.

Keywords: H pylori, Gastric acid secretion, Chronic gastritis