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©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2005; 11(21): 3171-3174
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3171
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3171
Resveratrol: A medical drug for acute pancreatitis
Zhen-Hua Ma, Qing-Yong Ma, Division of General Surgery of First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Zhen-Hua Ma, PhD, Division of General Surgery of First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. mazhenhua2005@163.com
Telephone: +86-29-85324009 Fax: +86-29-85323536
Received: July 23, 2004
Revised: July 25, 2004
Accepted: November 25, 2004
Published online: June 7, 2005
Revised: July 25, 2004
Accepted: November 25, 2004
Published online: June 7, 2005
Abstract
Accumulating evidence demonstrates that resveratrol, a natural polyphenolic compound extracted from plants, inhibit inflammation when administered. It has direct effects on suppression of platelet coagulation and cytokines production in many experimental models. Because microcirculation occlusion and cytokines over-production is involved in many diseases such as acute pancreatitis (AP), the discovery of resveratrol as platelet and cytokines inhibitors has shed light on the treatment of AP, which still has significant mortality and morbidity. It is anticipated that this natural polyphenol could serve as a therapeutic compound in managing AP through different pathways.
Keywords: Resveratrol, Drug, Acute pancreatitis