Clinical Research
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2005; 11(20): 3112-3117
Published online May 28, 2005. doi: 10.3748/wjg.v11.i20.3112
Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis
Chih-Yen Chen, Ching-Liang Lu, Jiing-Chyuan Luo, Full-Young Chang, Shou-Dong Lee, Yung-Ling Lai
Chih-Yen Chen, Ching-Liang Lu, Jiing-Chyuan Luo, Full-Young Chang, Shou-Dong Lee, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan, China
Yung-Ling Lai, AstraZeneca Taiwan Limited, Taipei, Taiwan, China
Author contributions: All authors contributed equally to the work.
Supported by the Research Foundation of Digestive Medicine, Taiwan, China
Correspondence to: Full-Young Chang, MD, Chief, Division of Gastroenterology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan, China.
Telephone: +886-2-28757308 Fax: +886-2-28739318
Received: May 12, 2004
Revised: May 13, 2004
Accepted: June 29, 2004
Published online: May 28, 2005

AIM: Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. Therefore, a perspective, double-blind, randomized comparison of esomeprazole tablets 40 mg (Nexium®) vs omeprazole capsules 20 mg (Losec®) in treating Chinese subjects with erosive/ulcerative reflux esophagitis (EE) was conducted.

METHODS: A total of 48 EE patients were enrolled and randomized into two treatment groups under 8-wk therapy: 25 receiving esomeprazole, while another 23 receiving omeprazole treatment. Finally, 44 completed the whole 8-wk therapy.

RESULTS: The difference in healing EE between two groups was 22.7% (72.7% vs 50.0%), not reaching significant value (P = 0.204). The median of the first time needed in relieving heartburn sensation was 1 d for both groups and the remission rates for heartburn on the 1st d after treatment were 77.3% and 65%, respectively (NS). The scores of various reflux relieving symptoms evaluated either by patients or by investigators were not different. Regarding drug safety, 28% of esomeprazole group and 26.1% of omeprazole group reported at least one episode of adverse effects, while constipation and skin dryness were the common side effects in both groups (NS).

CONCLUSION: Esomeprazole 40 mg is an effective and safe drug at least comparable to omeprazole in treating Chinese EE patients.

Keywords: Esomeprazole, Someprazole, Esophagitis