Liver fibrosis caused by choledocholith to regress after biliary drainage

doi:10.3748/wjg.v11.i13.2013

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2005; 11(13): 2013-2015
Published online Apr 7, 2005. doi: 10.3748/wjg.v11.i13.2013

Liver fibrosis caused by choledocholith to regress after biliary drainage

Zuo-Bing Chen, Shu-Sen Zheng, Guo-Zhi Hu, Yuan Gao, Chen-Yan Ding, Yun Zhang, Xue-Hong Zhao, Lin-Mei Ni

Zuo-Bing Chen, Shu-Sen Zheng, Yuan Gao, Chen-Yan Ding, Yun Zhang, Xue-Hong Zhao, Lin-Mei Ni, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China

Guo-Zhi Hu, Department of Surgery, Zhuji County Peoples’ Hospital, Zhuji 311800, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Zuo-Bing Chen, MD., Department of Emergency Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing-chun Road, Hangzhou 310003, Zhejiang Province, China. chenzuobing@hotmail.com

Telephone: +86-571-87236303

Received: November 8, 2004
Revised: November 9, 2004
Accepted: December 3, 2004
Published online: April 7, 2005

Abstract

AIM: To study the correlation between liver fibrosis severity and biliary drainage in patients with choledocholith.

METHODS: A follow-up study on seven patients with liver fibrosis due to choledocholith was made. The data, including biochemical tests (aspartate aminotransferase, alanine aminotransferase) and liver histological features before and after biliary drainage, were collected and studied. The fibrosis severity was scored on a scale from 0 to 3, with 0 denoting none, 1 portal and periportal fibrosis, 2 the presence of numerous fiber septa, and 3 cirrhosis. The average liver fibrosis severity scores of the first and second biopsy were compared with statistical method.

RESULTS: The first, second liver fibrosis severity scores of these seven patients were 2,1; 2,1; 1,0; 1,1; 2,1; 2,1; 1,0 respectively. The results showed that the average liver fibrosis severity score of the second liver biopsy decreased significantly compared with the first liver biopsy (n = 7, t = 4.25, P<0.05).

CONCLUSION: Liver fibrosis due to choledocholith may regress after biliary drainage.

Keywords: Liver fibrosis, Regress, Biliary drainage