Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions

doi:10.3748/wjg.v10.i6.800

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 6

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2776)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

424

HTML

2098

Figures (1-1)

134

Tables (1-3)

120

Sum=2776

Mar 15, 2004 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (22)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Mar 15, 2004; 10(6): 800-803
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.800

Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions

Xian-Long Ling, Dian-Chun Fang, Rong-Quan Wang, Shi-Ming Yang, Li Fang

Xian-Long Ling, Dian-Chun Fang, Rong-Quan Wang, Shi-Ming Yang, Li Fang, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30070043, and Scientific Research Project of Chinese PLA during the 10^th Five-year plan period, No. 01Z075

Correspondence to: Dian-Chun Fang, M.D., Ph.D. Southwest Hospital, Third Military Medical University, Chongqing 400038, China. fangdianchun@hotmail.com

Telephone: +86-23-68754624 Fax: +86-23-68754124

Received: August 26, 2003
Revised: September 2, 2003
Accepted: September 18, 2003
Published online: March 15, 2004

Abstract

AIM: To evaluate the role of mitochondrial microsatellite instability (mtMSI) in gastric carcinogenesis.

METHODS: MtMSI was measured with PCR-single strand conformation polymophism (PCR-SSCP) in 68 cases of advanced gastric cancer, 40 cases of chronic gastritis, 30 cases of intestinal metaplasia and 20 cases of dysplasia.

RESULTS: MtMSI was observed in 12.5% (5 of 40) of chronic gastritis, 20.0% (6 of 30) of intestinal metaplasia, 25.0% (5 of 20) of dysplasia and 38.2% (26 of 68) of gastric cancer. These findings showed a sequential accumulation of mtMSI in the histological progression from chonic gastritis to gastric cancer. An association of mtMSI with intestinal histological type and distal location was found (P = 0.001 and P = 0.002), whereas no significant correlation was found between mtMSI and age at diagnosis, sex, tumor size, depth of invasion, lymph node spread and clinical stages (P > 0.05).

CONCLUSION: MtMSI may play an early and important role in the gastric carcinogenesis pathway, especially in the intestinal type and distal gastric cancer.

Keywords: $[Keywords]