Nuclear and mitochondrial DNA microsatellite instability in Chinese hepatocellular carcinoma

doi:10.3748/wjg.v10.i3.371

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Feb 1, 2004; 10(3): 371-375
Published online Feb 1, 2004. doi: 10.3748/wjg.v10.i3.371

Nuclear and mitochondrial DNA microsatellite instability in Chinese hepatocellular carcinoma

Dian-Chun Fang, Li Fang, Rong-Quan Wang, Shi-Ming Yang

Dian-Chun Fang, Li Fang, Rong-Quan Wang, Shi-Ming Yang, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30070043

Correspondence to: Dian-Chun Fang, M.D., Ph.D. Southwest Hospital, Third Military Medical University, Chongqing 400038, China. fangdianchun@hotmail.com

Telephone: +86-23-68754624 Fax: +86-23-68754124

Received: June 5, 2003
Revised: August 9, 2003
Accepted: August 16, 2003
Published online: February 1, 2004

Abstract

AIM: To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondral microsalellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI.

METHODS: nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular carcinoma.

RESULTS: mtMSI was detected in 11 out of the 52 cases of hepatocellular carcinoma (21.2%). Among the 11 cases of hepatocellular carcinoma with mtMSI, 7 occured in one locus and 4 in 2 loci. The frequency of mtMSI in the 52 cases of hepatocellular carcinoma showed no correlation to sex, age, infection of hepatitis B, liver cirrhosis as well as positive AFP of the patients (P > 0.05). In addition, nMSI was detected in 3 out of 52 cases of hepatocellular carcinoma (5.8%) and there was no correlation of the incidence of mtMSI to that of nMSI (P > 0.05).

CONCLUSION: mtMSI may be involved in the coccurrence and development of hepatocellular carcinoma and it is independent of nMSI.

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