Esophageal Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 2004; 10(20): 2931-2935
Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.2931
Endoscopic survey of esophageal cancer in a high-risk area of China
Xu-Jing Lu, Zhi-Feng Chen, Cui-Lan Guo, Shao-Sen Li, Wen-Long Bai, Guo-Liang Jin, Yu-Xia Wang, Fan-Shu Meng, Feng Gao, Jun Hou
Xu-Jing Lu, Zhi-Feng Chen, Jun Hou, Hebei Cancer Institute and Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Cui-Lan Guo, Shao-Sen Li, Wen-Long Bai, Guo-Liang Jin, Yu-Xia Wang, Fan-Shu Meng, Feng Gao, Cixian Cancer Institute, Cixian 056500, Hebei Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Tenth Five-Year Scientific Championship Project, No. 2001BA703B10
Correspondence to: Dr. Jun Hou, Hebei Cancer Institute, Jiankanglu 12, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China.
Telephone: +86-311-6033511 Fax: +86-311-6077634
Received: October 9, 2003
Revised: November 21, 2003
Accepted: December 16, 2003
Published online: October 15, 2004

AIM: To characterize the histological types of esophageal and cardiac mucosa by endoscopic survey of a population in a high-risk area of esophageal cancer of China.

METHODS: A selected cohort of residents in Cixian County during December 2001 and May 2002 was surveyed by using Lugol’s staining, followed by computer-based statistical analysis of the data with SPSS 10.0 software.

RESULTS: Histologically, the detection rates of squamous epithelial acanthosis, squamous epithelial atrophy, and basal cell hyperplasia in the esophagus were 1.9% (38/2013), 0.1% (3/2013) and 0.9% (18/2013) respectively, and those of mild, moderate, and severe esophagitis were 34.9% (703/2013), 1.6% (33/2013) and 0.2% (2/2013) respectively. Mild, moderate, and severe esophageal dysplasia were detected in 8.6% (172/2013), 7.8% (157/2013) and 2.6% (53/2013) respectively in the selected population, whereas in situ carcinoma, intramucosal carcinoma, invasive squamous carcinoma of the esophagus in 2.5% (50/2013), 0.2% (4/2013) and 0.7% (14/2013) respectively. The detection rates of non-atrophic gastritis and atrophic gastritis of the cardia were 36.3% (730/2013) and 11.5% (232/2013) respectively, with mild and severe dysplasia of the cardia detected in 2.5% (51/2013) and 0.8% (17/2013), respectively, in this population; the rates of intramucosal adenocarcinoma and invasive adenocarcinoma of the cardia were 0.1% (3/2013) and 0.8% (17/2013) respectively. The detection rate of esophageal cancer at early stage was 79.4% (54/68). The survey rate (ratio of examined population to expected population) was 73.8% (2013/2725).

CONCLUSION: Histologic types of the esophageal and cardiac mucosa were characterized by endoscopic survey in a high-risk population of esophageal cancer, which may help the early detection and treatment of esophageal and cardiac cancers and dysplasia, and reduce the mortality of such malignancies.

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