Basic Research
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 1, 2004; 10(17): 2519-2523
Published online Sep 1, 2004. doi: 10.3748/wjg.v10.i17.2519
Morphologic and biomechanical changes of rat oesophagus in experimental diabetes
Yan-Jun Zeng, Jian Yang, Jing-Bo Zhao, Dong-Hua Liao, En-Ping Zhang, Hans Gregersen, Xiao-Hu Xu, Hong Xu, Chuan-Qing Xu
Yan-Jun Zeng, Xiao-Hu Xu, Hong Xu, Chuan-Qing Xu, Forensic Medicine Department, Medical College, Santou University, Santou 515031, Guangdong Province, China
Jian Yang, En-Ping Zhang, Beijing University of Technology, Beijing 100022, China
Jing-Bo Zhao, Dong-Hua Liao, Hans Gregersen, Department of Gastrointestinal Surgery, Aalborg University, Denmark
Author contributions: All authors contributed equally to the work.
Correspondence to: Yan-Jun Zeng, Forensic Medicine Department, Medical College, Shantou University, Shantou 515031, Guangdong Province, China. yjzeng@bjut.edu.cn
Telephone: +86-10-67391685 Fax: +86-10-67391738
Received: August 23, 2003
Revised: October 4, 2003
Accepted: October 22, 2003
Published online: September 1, 2004
Abstract

AIM: To study morphologic and biomechanical changes of oesophagus in diabetes rats.

METHODS: Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent (type I). The samples were excised and studied in vitro using a self-developed biomaterial test machine.

RESULTS: The body mass was decreased after 4 d with STZ treatment. The length of esophagus shortened after 4, 7, 14 d. The opening angle increased after 14 d. The shear, longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment.

CONCLUSION: The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent. This alteration will lead to some dysfunction of movement. For example, tension of esophageal wall will change due to some obstructive disease.

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