KAI1 gene expression in colonic carcinoma and its clinical significances

doi:10.3748/wjg.v10.i15.2245

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Aug 1, 2004; 10(15): 2245-2249
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2245

KAI1 gene expression in colonic carcinoma and its clinical significances

De-Hua Wu, Li Liu, Long-Hua Chen, Yan-Qing Ding

De-Hua Wu, Long-Hua Chen, Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China

Li Liu, Yan-Qing Ding, Department of Pathology, First Military Medical University, Guangzhou 510515, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation, No. 30370649

Correspondence to: Dr. Yang-Qing Ding, Department of Pathology, First Military Medical University, Guangzhou 510515, Guangdong Province, China. dyq@fimmu.com

Telephone: +86-20-61642148 Fax: +86-20-61642148

Received: December 12, 2003
Revised: December 23, 2003
Accepted: February 1, 2004
Published online: August 1, 2004

Abstract

AIM: To investigate KAI1 gene expression in the progression of human colonic carcinoma and its clinical significances.

METHODS: KAI1 expression was detected by in situ hybridization and immunohistochemistry in the 4 established cell lines of colorectal carcinoma with different metastatic potentials, and in 80 specimens of colonic carcinoma, 21 colonic carcinoma specimens with lymphatic metastasis and 20 controls of normal colonic mucosa.

RESULTS: The expressions of KAI1 in HT29 and SW480 cell lines were higher than those in LoVo and SW620. The expression of KAI1 gene was significantly higher in colorectal carcinoma compared with normal colonic mucosa and lymphatic metastasis (χ² = 46.838, P < 0.01). The expression of KAI1 gene had no relationship with histological grade. The KAI1 expressions in Dukes A and B carcinoma were higher at both mRNA and protein levels compared to Dukes C carcinoma (χ² = 16.061, P < 0.05). The expression of KAI1 in colonic carcinoma specimens with lymphatic metastasis was almost lost. The results of in situ hybridization were in concordance with immunohistochemistry.

CONCLUSION: KAI1 is highly related to the metastasis of colonic carcinoma and may be a useful indicator of metastasis in colonic carcinoma.

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