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©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 15, 2004; 10(12): 1709-1715
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1709
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1709
Review of cytokine profiles in patients with hepatitis
Qiao-Ling Sun, The Department of Biotechnological Pharmaceutics, Taishan Medical University, Tai’an 271000, Shangdong Province, China
Wei Ran, Basic Medical Research Institute, Taishan Medical University, Tai’an 271000, Shangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Qiao-Ling Sun, The Department of Biotechnological Pharmaceutics, Taishan Medical University, Tai’an 271000, Shangdong Province, China. sunsunpublic@sina.com
Telephone: +86-538-6222435
Received: September 18, 2003
Revised: October 5, 2003
Accepted: October 12, 2003
Published online: June 15, 2004
Revised: October 5, 2003
Accepted: October 12, 2003
Published online: June 15, 2004
Abstract
The development of T helper 1 versus T helper 2 cells is a major branch point in the immune response and is an important determinant of the body’s response to an infectious pathogen, leading to protection of the host or dissemination of the disease. Resent studies have shown that there exist macrophage activation states in parallel to the T helper cell type 1/2 paradigm, and the T helper 1 development process is governed to a great degree by cytokine IL-12 provided mainly by antigen presenting cells such as macrophages and dendritic cells. A model in patients with hepatitis is proposed that links the pathogen, macrophage activation and T helper cell polarization.
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