Bai XF, Ni XG, Zhao P, Liu SM, Wang HX, Guo B, Zhou LP, Liu F, Zhang JS, Wang K, Xie YQ, Shao YF, Zhao XH. Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol 2004; 10(10): 1466-1470 [PMID: 15133855 DOI: 10.3748/wjg.v10.i10.1466]
Corresponding Author of This Article
Xiao-Hang Zhao, M.D., Ph.D. National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. firstname.lastname@example.org
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Xiao-Feng Bai, Xiao-Guang Ni, Ping Zhao, Shang-Mei Liu, Hui-Xin Wang, Lan-Ping Zhou, Fang Liu, Jin-Sheng Zhang, Yong-Qiang Xie, Yong-Fu Shao, Xiao-Hang Zhao, National Laboratory of Molecular Oncology, Department of Abdominal Surgery, Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Kun Wang, Xiao-Hang Zhao, Beijing Yanjing Hospital, Beijing 100037, China
Bing Guo, Department of Head, Neck and Breast, Mudanjiang Tumor Hospital, Mudanjiang 157009, Heilongjiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by National Natural Science Foundation of China NO. 30240050, 30225045, 39990570, 30171049, and 30370713 and National High Tech R & D Program of China, 2001AA227091
Correspondence to: Xiao-Hang Zhao, M.D., Ph.D. National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. email@example.com
Telephone: +86-10-67709015 Fax: +86-10-67709015
Received: January 15, 2004 Revised: February 17, 2004 Accepted: February 24, 2004 Published online: May 15, 2004
AIM: To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance.
METHODS: Annexin I expression was analyzed by Western blot and immunohistochemical staining in pancreatic adenocarcinoma and multi-tissue microarrays (MTAs).
RESULTS: Western blot analysis showed that annexin I was overexpressed in 84.6% (11/13) pancreatic ductal adenocarcinomas. Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4% (30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4% (7/38) (P < 0.01). In the meantime, the high expression of annexin 1 was correlated with the poor differentiation of pancreatic adenocarcinoma.
CONCLUSION: Annexin 1 overexpression is a frequent biological marker and correlates with the differentiation of pancreatic cancer during tumorigenesis.