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Blekic W, Rossignol M, D’Hondt F. Examining attentional avoidance in post-traumatic stress disorder: an exploratory 'Face in the Crowd' paradigm using eye-tracking. Eur J Psychotraumatol 2025; 16:2462489. [PMID: 39936336 PMCID: PMC11823380 DOI: 10.1080/20008066.2025.2462489] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/16/2024] [Revised: 01/27/2025] [Accepted: 01/29/2025] [Indexed: 02/13/2025] Open
Abstract
Background: Maladaptive patterns of attention to emotional stimuli are a clinical feature of posttraumatic stress disorder (PTSD). Using eye-tracking-based methodology, research points out the presence of sustained attention to threatening stimuli in individuals with PTSD. However, most eye-tracking studies in this field used free-viewing tasks on negative stimuli.Methods: PTSD patients (n = 38), trauma-exposed healthy controls (TEHC; n = 30), and non-trauma-exposed healthy controls (HC; n = 33) performed a Face in the Crowd (FiC) task. The FiC task was chosen to explore specific responses to emotional stimuli within a competitive visual environment, thus providing insights into visual search patterns. Both reaction time and gaze patterns (dwell time, scanpath length, first fixation duration, and latency) were recorded.Results: Individuals with a provisional PTSD diagnosis presented decreased dwell time on both positive and negative targets in comparison with HC and TEHC, as well as shorter scanpath length for all matrixes when no targets were present. No evidence of attentional bias was observed in the TEHC group based on reaction times or eye-tracking measures in response to positive, negative, or neutral cues.Discussion: We found an attentional avoidance pattern among PTSD patients, along with indexes of lowered perceptual threshold for all emotional information. This study allows raising the question of cognitive load on the emergence of differential attentional strategies presented by PTSD participants. We discuss the generalization of fear processes across different emotional stimuli and underscore the need for incorporating a variety of emotional stimuli in PTSD research.
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Affiliation(s)
- Wivine Blekic
- University of Lille, Inserm, CHU Lille, U1172 – LilNCog – Lille Neuroscience & Cognition, Lille, France
- Centre national de ressources et de résilience Lille-Paris (Cn2r), Lille, France
| | - Mandy Rossignol
- Cognitive Psychology and Neuropsychology Lab, University of Mons, Mons, Belgium
| | - Fabien D’Hondt
- University of Lille, Inserm, CHU Lille, U1172 – LilNCog – Lille Neuroscience & Cognition, Lille, France
- Centre national de ressources et de résilience Lille-Paris (Cn2r), Lille, France
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2
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Lev T, Gober Dykan CD, Lazarov A, Bar-Haim Y. Attention bias variability as a cognitive marker of PTSD: A comparison of eye-tracking and reaction time methodologies. J Affect Disord 2025; 383:426-434. [PMID: 40311811 DOI: 10.1016/j.jad.2025.04.164] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/26/2024] [Revised: 04/26/2025] [Accepted: 04/28/2025] [Indexed: 05/03/2025]
Abstract
Identification of reliable behavioral markers for posttraumatic stress disorder (PTSD) can offer objective measures beyond self-reports to aid in diagnosis, treatment, and prevention. Attention bias variability (ABV), defined as fluctuations in attention toward or away from threat-related stimuli, has been associated with PTSD. Reaction time-based ABV (RT-ABV) has been extensively studied and shown to be linked with PTSD symptomatology. An eye-tracking-based ABV index (ET-ABV) was only recently introduced, and results show that it may be associated with trauma exposure rather than with PTSD symptoms. However, these two ABV types have yet to be studied within the same sample. The current study explored the association between trauma exposure, PTSD symptom severity, and ABV measures, applying both the classic RT-ABV and the new ET-ABV in the same sample. Participants with PTSD (n = 41), trauma-exposed healthy controls (TEHC; n = 71), and non-trauma-exposed healthy controls (HC; n = 38) completed an eye-tracking free-viewing matrix task and a response-based dot-probe task using the same threat-related stimuli (angry faces) across tasks. Results indicate that both RT-ABV and ET-ABV were significantly higher in participants with PTSD compared to participants in the TEHC and HC groups, with no significant difference between the latter groups. Additional analyses indicate that although moderately correlated, each of the ABV measures explains unique portions of the variance in PTSD severity. This study replicates and extends prior findings on the association between ABV and PTSD and highlights the potential of ET-ABV as a novel and reliable marker for PTSD severity.
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Affiliation(s)
- Tal Lev
- School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
| | | | - Amit Lazarov
- School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel
| | - Yair Bar-Haim
- School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
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3
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Shikh A, Mañaná J, Myruski S, Rombola C, Weierich M, Ortin-Peralta A, Miranda R. Lower- versus higher-order suicide-related attentional processing measures as predictors of adolescent suicide ideation and attempt. Psychiatry Res 2025; 349:116524. [PMID: 40311151 DOI: 10.1016/j.psychres.2025.116524] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/15/2025] [Revised: 04/22/2025] [Accepted: 04/25/2025] [Indexed: 05/03/2025]
Abstract
Cognitive theories suggest that biased suicide-related attentional processing confers risk for suicide ideation (SI) and attempts (SAs), but studies to date, which have been mixed, have not compared lower- and higher-order measures of attentional processes. The present study examined attention fixation, attention disengagement, and semantic interference as predictors of future SI and SA among adolescents, a high-risk age group for onset of SI and SAs. Adolescents (N = 135) (75 % female), ages 12-19 (M = 15.4, SD = 1.9), who presented to emergency or outpatient departments with SI (n = 84) or a SA (n = 51) completed an attention disengagement task (ADT), Suicide Stroop task, and the Attentional Fixation on Suicide Experiences Questionnaire (AFSEQ). A subsample of adolescents completed 3-month (n = 98) and 12-month follow-up assessments (n = 96) of SI severity and SA (n = 118) (based on adolescent or caregiver report). AFSEQ score predicted SI severity at 3- and 12-months, respectively, b = 0.47, p < .05; b = 0.44, p < .01, adjusting for ADT and relevant covariates, and also predicted SA at follow up, OR = 1.06, 95 % CI = 1.00-1.12, p < .05, adjusting for SA history, but not after adjusting for SI. Greater suicide-related attention disengagement difficulty predicted greater SI severity at 12 months, b = 0.03, p < .05, but not at 3 months. Self-reported, higher-order, attentional fixation may better predict future suicide-related risk among diverse adolescents than lower-order cognitive tasks assessing suicide-related attention disengagement or semantic interference.
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Affiliation(s)
- Allan Shikh
- Hunter College, City University of New York, NY, USA; University of Rochester Medical Center, Rochester, NY, USA
| | | | - Sarah Myruski
- Pennsylvania State University, University Park, PA, USA
| | | | | | - Ana Ortin-Peralta
- Yeshiva University, Bronx, NY, USA; Albert Einstein College of Medicine, Bronx, NY, USA
| | - Regina Miranda
- Hunter College, City University of New York, NY, USA; The Graduate Center, City University of New York, NY, USA.
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4
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Lautenbach F, O'Connor EJ, Crozier AJ, Murphy A, Immink MA. Attention Distraction and Traction by Task-Irrelevant Emotion Information in Athletes: Evidence from the Sport Emotional Stroop Task-English. PSYCHOLOGY OF SPORT AND EXERCISE 2025:102913. [PMID: 40490238 DOI: 10.1016/j.psychsport.2025.102913] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/16/2025] [Revised: 04/20/2025] [Accepted: 06/06/2025] [Indexed: 06/11/2025]
Abstract
During competition, athletes must suppress task-irrelevant stimuli to effectively attend to performance-related information. Understanding how emotional stimuli capture attention and consume cognitive resources is vital for studying attention regulation in athletes. This study assessed athletes' ability to inhibit emotional distractions using the Sport Emotional Stroop Task in English (SEST-E). Administered to 66 English-speaking athletes, the task revealed significantly longer reaction time for negative valence sports words and shorter reaction time for positive valence words compared to neutral valence words. These results support the valence hypothesis and the negativity bias. Emotional valence distinctly influences attentional processing, with negative stimuli prolonging distraction by task-irrelevant information and positive stimuli facilitating traction to task-relevant information. The latter findings provide evidence for the mood-as-information theory. Incorporating negative valence stimuli into training to improve attention control and emphasizing positive aspects of training and competition are practical applications from the present findings. Overall, the SEST-E appears to be a valuable tool for researchers and practitioners to assess and address emotional influence on athlete performance.
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Affiliation(s)
- Franziska Lautenbach
- Sports Psychology, Institute of Sport Science, Humboldt-Universität zu Berlin, Berlin, Germany.
| | - Edward J O'Connor
- Allied Health and Human Performance and Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia
| | - Alyson J Crozier
- Allied Health and Human Performance and Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia
| | - Alistair Murphy
- Tennis Australia, Sports Science and Sports Medicine Unit, Melbourne, Australia
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5
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Spalding DM, Ejoor T, Zhao X, Bomarsi D, Ciliberti M, Ottaviani C, Valášek M, Hirsch C, Critchley HD, Meeten F. Effects of A Brief Resonance Frequency Breathing Exercise on Heart Rate Variability and Inhibitory Control in the Context of Generalised Anxiety Disorder. Appl Psychophysiol Biofeedback 2025; 50:213-233. [PMID: 39924637 DOI: 10.1007/s10484-025-09687-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 01/04/2025] [Indexed: 02/11/2025]
Abstract
Generalised anxiety disorder (GAD) is associated with cognitive and physiological symptoms including uncontrollable worry, inhibitory control deficits, and low heart rate variability (HRV). Literature linking HRV and inhibition in GAD is predominantly correlational. The present experiment investigated whether HRV has a causal role in maintaining inhibitory control. Participants (N = 135, 111 female) aged 18-37 reporting high levels of symptoms associated with GAD (GAD-7 scores ≥ 10; Penn State Worry Questionnaire scores ≥ 56) were assigned to an experimental or active control condition and completed baseline measures of HRV, respiration rate, and inhibitory control. The experimental condition completed resonance frequency breathing (RFB) training, and the control condition practiced breathing at their mean breathing rate before repeating the inhibitory control assessment. Participants also completed the breathing training before a behavioural worry task. The experimental condition was predicted to show increased HRV, alongside improved inhibitory control and better ability to stop worrying as compared to the control condition. HRV increased during the experimental condition, as compared to the control condition. However, there were no significant effects of RFB on inhibitory control or worry, or on HRV during the inhibitory control tasks. In conclusion, RFB can increase HRV in high GAD scorers, but further research is required to determine whether there is a relationship between increased HRV and symptoms of GAD in a single session experiment.
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Affiliation(s)
- David M Spalding
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
| | - Toni Ejoor
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
| | - Xiaochang Zhao
- Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
| | - Daniele Bomarsi
- Department of Psychology, Sapienza University of Rome, Rome, Italy
| | | | - Cristina Ottaviani
- Department of Psychology, Sapienza University of Rome, Rome, Italy
- Functional Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy
| | - Milan Valášek
- Faculty of Architecture and Urbanism, Bauhaus University Weimar, Weimar, Germany
| | - Colette Hirsch
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
- South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London, UK
| | - Hugo D Critchley
- Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK
- Sussex Partnership NHS Foundation Trust, Worthing, UK
- Sussex Neuroscience, University of Sussex, Brighton, UK
| | - Frances Meeten
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London, UK.
- School of Psychology, University of Sussex, Brighton, UK.
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6
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Silva F, Garrido MI, Soares SC. The effect of anxiety and its interplay with social cues when perceiving aggressive behaviours. Q J Exp Psychol (Hove) 2025; 78:1124-1138. [PMID: 38785293 PMCID: PMC12095894 DOI: 10.1177/17470218241258209] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2023] [Revised: 05/13/2024] [Accepted: 05/13/2024] [Indexed: 05/25/2024]
Abstract
Contextual cues and emotional states carry expectations and biases that are used to attribute meaning to what we see. In addition, emotional states, such as anxiety, shape our visual systems, increasing overall, and particularly threat-related, sensitivity. It remains unclear, however, how anxiety interacts with additional cues when categorising sensory input. This is especially important in social scenarios where ambiguous gestures are commonplace, thus requiring the integration of cues for a proper interpretation. To this end, we decided to assess how states of anxiety might bias the perception of potentially aggressive social interactions, and how external cues are incorporated in this process. Participants (N = 71) were tasked with signalling the presence of aggression in ambiguous social interactions. Simultaneously, an observer (facial expression) reacted (by showing an emotional expression) to this interaction. Importantly, participants performed this task under safety and threat of shock conditions. Decision measures and eye-tracking data were collected. Our results showed that threat of shock did not affect sensitivity nor criterion when detecting aggressive interactions. The same pattern was observed for response times. Drift diffusion modelling analysis, however, suggested quicker evidence accumulation when under threat. Finally, dwell times over the observer were higher when under threat, indicating a possible association between anxiety states and a bias towards potentially threat-related indicators. Future probing into this topic remains a necessity to better explain the current findings.
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Affiliation(s)
- Fábio Silva
- William James Center for Research, University of Aveiro, Aveiro, Portugal
| | - Marta I. Garrido
- Melbourne School of Psychological Sciences, The University of Melbourne, Vic, Australia
- Graeme Clark Institute for Biomedical Engineering, The University of Melbourne, Vic, Australia
| | - Sandra C. Soares
- William James Center for Research, University of Aveiro, Aveiro, Portugal
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7
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Duan N, Zhang Y, Wang S, Guan J, Ji Y, Huang W, Qian R, Zheng H, Bai T, Tian Y. Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis. Psychiatry Res Neuroimaging 2025; 349:111989. [PMID: 40203547 DOI: 10.1016/j.pscychresns.2025.111989] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2025] [Revised: 03/18/2025] [Accepted: 04/02/2025] [Indexed: 04/11/2025]
Abstract
Non-invasive brain stimulation (NIBS) has the potential to treat generalized anxiety disorder (GAD). To assess the efficacy (response/remission/post-treatment continuous anxiety severity scores) and acceptability (failure to complete treatment for any reason) of NIBS, we searched PubMed, Web of Science, and the Cochrane Library (as of April 2024) for articles on NIBS for GAD and conducted a network meta-analysis of eight randomized trials (20 treatment arms, 405 participants). Data were pooled using standardized mean difference (SMD) and odds ratio (OR) with 95 % confidence interval (CI). Repetitive transcranial magnetic stimulation (rTMS) was the most widely studied treatment for GAD. The right dorsolateral prefrontal cortex (DLPFC) was the most common treatment target for GAD. High-frequency rTMS showed higher response rates (OR 291.40, 95 % CI 13.08 to 6490.21) and remission rates (OR 182.14, 95 % CI 8.72 to 3805.76) compared with other active therapies. Continuous theta burst stimulation (cTBS) greatly improved continuous post-treatment anxiety severity scores (SMD -2.56, 95 % CI -3.16 to -1.96). No significant differences in acceptability were found between the treatment strategies and the sham stimulation group. These findings provide evidence to consider NIBS techniques as alternative or adjunctive treatments for GAD.
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Affiliation(s)
- Nanxue Duan
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Yulin Zhang
- Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China
| | - Shaoyang Wang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Jian Guan
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Yang Ji
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Wanling Huang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Rui Qian
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Hao Zheng
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
| | - Tongjian Bai
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
| | - Yanghua Tian
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 230088, China.
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8
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Reutter M, Teigeler J, Gamer M. The influence of (social) anxiety and visual exploration on threat responding and generalization. Behav Res Ther 2025; 189:104746. [PMID: 40250248 DOI: 10.1016/j.brat.2025.104746] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/25/2024] [Revised: 03/25/2025] [Accepted: 04/14/2025] [Indexed: 04/20/2025]
Abstract
Fear generalization has been identified as an important mechanism that might contribute to the etiology and maintenance of anxiety disorders. It is, however, yet unclear to what degree attentional processes contribute to overgeneralization of fear in clinical samples. To address this issue, we utilized a set of facial photographs that was meticulously created such that pairs of faces could either be distinguished by looking into the eyes or the region around mouth and nose, respectively. These pairs were then employed as CS+ and CS- in a differential fear conditioning paradigm followed by a generalization test with morphs in steps of 20 %, creating a continuum between CS+ and CS-. In a sample with diverse levels of social and general anxiety (N = 87), we demonstrated that the amount of fear generalization depends on attentional orienting towards diagnostic facial features. While social anxiety did not affect the shape of generalization gradients, we observed altered visual exploration patterns and a distinct multi-phasic heart rate modulation in participants with higher social anxiety. General anxiety symptomatology was also related to these characteristics of visual exploration and additionally predicted a broad elevation of threat ratings. In summary, fear generalization depends on attentional deployment. Future work should build on these findings to further explore these processes in clinical populations.
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Affiliation(s)
- Mario Reutter
- Experimental Clinical Psychology, Department of Psychology, University of Würzburg, Würzburg, Germany.
| | - Janna Teigeler
- Experimental Clinical Psychology, Department of Psychology, University of Würzburg, Würzburg, Germany
| | - Matthias Gamer
- Experimental Clinical Psychology, Department of Psychology, University of Würzburg, Würzburg, Germany
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9
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Rogers AA, Halvari AEM, Solbakk AK, Johnsen JAK. Testing Dental Anxiety and Self-Care Behaviours as Mediators of the Association Between Executive Functioning and Oral Health Among Young Adults. Community Dent Oral Epidemiol 2025. [PMID: 40432184 DOI: 10.1111/cdoe.13047] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2023] [Revised: 01/31/2025] [Accepted: 05/16/2025] [Indexed: 05/29/2025]
Abstract
BACKGROUND Increased support for oral health during young adulthood is needed to address trends in oral disease over the life course. Executive functioning (EF) may play a role in supporting oral health but has received little attention. EF represents the capacity to control cognitive information, feelings and behaviour. The current study aimed to explore the association between EF and oral health among young adults and investigate potential mediators. METHODS Young adults aged 18-30 years were recruited from five universities within Norway to take part in a cross-sectional digital survey. Participants self-reported EF, toothbrushing, flossing, dental fear and anxiety (DFA), and provided ratings on two measures of oral health: self-rated oral health (SROH) and self-reported oral health-related quality of life (OHRQoL). Separate analyses were conducted for each outcome. Linear regression was used to test the association between EF and oral health, and whether toothbrushing, flossing, or DFA mediated this effect. RESULTS Data from 344 participants were analysed. Average SROH was quite good (M = 4.13), several participants (60.5%) reported some impact on OHRQoL. In the SROH model, EF difficulties directly predicted oral health (β = -0.26), and DFA mediated the relationship (ab = -0.03, p < 0.05). In the OHRQoL model, EF difficulties again predicted performances impacted (β = 0.27), and DFA mediated the relationship (ab = 0.04, p < 0.05). CONCLUSION EF is related to oral health outcomes among young adults and the relationship is mediated by DFA. Studies are encouraged to continue exploring these relationships, with longitudinal studies needed to provide more insight into the potential role of EF as a protective factor for the development of DFA and oral health problems.
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Affiliation(s)
- Adam A Rogers
- Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
| | - Anne E M Halvari
- Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
- Oral Health Centre of Expertise in Eastern Norway, Oslo, Norway
| | - Anne-Kristin Solbakk
- RITMO Centre for Interdisciplinary Studies in Rhythm, Time, and Motion, Department of Psychology, University of Oslo, Oslo, Norway
- Department of Neurosurgery, Oslo University Hospital, Oslo, Norway
- Department of Neuropsychology, Helgeland Hospital, Helgeland, Norway
| | - Jan-Are K Johnsen
- Department of Clinical Dentistry, UiT The Arctic University of Norway, Tromso, Norway
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Zhang H, Zhang M, Li N, Wei WZ, Yang LX, Li YY, Zu ZY, Ma LJ, Wang HX, Wang K, Li XM. Event-related potentials reveal hypnotherapy's impact on attention bias in social anxiety disorder. World J Psychiatry 2025; 15:102552. [DOI: 10.5498/wjp.v15.i5.102552] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Revised: 12/24/2024] [Accepted: 03/04/2025] [Indexed: 04/30/2025] Open
Abstract
BACKGROUND Exploring hypnotherapy's potential to modulate attention bias offers promising avenues for treating social anxiety disorder (SAD).
AIM To determine if hypnotherapy can alleviate social anxiety by influencing attention bias, specifically identifying the aspects of attention processes affected by hypnosis.
METHODS In this study, 69 SAD participants were divided into three groups based on their Liebowitz Social Anxiety Scale scores: Experimental group, control group, and baseline group. The experimental group (n = 23) underwent six weekly hypnosis sessions, while the control (n = 23) and baseline groups (n = 23) received no treatment. To evaluate alterations in SAD severity and attention bias towards threatening stimuli following hypnotherapy, we employed a combination of self-report questionnaires, an odd-one-out task, and electroencephalography recordings.
RESULTS The experimental group showed significant reductions in P1, N170, N2pc, and late positive potential (LPP) brain wave activities during attention sensitivity and disengagement conditions. This indicates that hypnotherapy modulates early-stage face processing and later-stage emotional evaluation of threat-related stimuli in SAD patients.
CONCLUSION Our findings highlight P1, N170, N2pc, and LPP as key neural markers in SAD treatment. By identifying these neural markers influenced by hypnotherapy, we offer insight into the mechanisms by which this treatment modality impacts attentional processes, potentially easing SAD symptoms.
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Affiliation(s)
- Han Zhang
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Mi Zhang
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Ni Li
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Wen-Zhuo Wei
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Lin-Xi Yang
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Yong-Yi Li
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Zhen-Yue Zu
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Li-Jun Ma
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Hui-Xue Wang
- School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Kai Wang
- Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230032, Anhui Province, China
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei 230032, Anhui Province, China
| | - Xiao-Ming Li
- Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
- Department of Medical Psychology, School of Mental Health and Psychological Science, Anhui Medical University, Hefei 230032, Anhui Province, China
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11
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Zidda F, Steiger-White F, Winkelmann T, Ruttorf M, Andoh J, Nees F, Flor H. Early processing of traumatic material and contextual information in posttraumatic stress disorder and its relation to memory impairments. Sci Rep 2025; 15:16362. [PMID: 40348801 PMCID: PMC12065850 DOI: 10.1038/s41598-025-00322-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Accepted: 04/28/2025] [Indexed: 05/14/2025] Open
Abstract
Posttraumatic stress disorder (PTSD) is characterized by exaggerated responses to trauma-relevant cues and impairments in relation to contextual information. However, it is not clear whether this dysfunction is related only to memory processes, or whether early perceptual and attentional processing is already dysfunctional. We examined early processing and retrieval of trauma-related cues and neutral contexts in 20 individuals diagnosed with PTSD (PTSD) and 20 trauma-exposed controls without diagnosis of PTSD (NPTSD) using simultaneous high-density electroencephalography and eye-tracking. A group of 20 non-trauma-exposed healthy controls (HC) was employed to test for responses to trauma-unrelated cues and contexts. The earliest visual event-related potential (C1) was positive for individuals diagnosed with PTSD and negative for NPTSD, suggesting enhanced early visual processing of the cue. Eye-tracking showed that PTSD but not NPTSD displayed significantly longer latencies before looking at contexts than at trauma-related cues. The PTSD group performed significantly worse than the NPTSD group in correctly retrieving rearranged cue/context associations compared to consistent associations. Memory strength for rearranged cue-context pairs was significantly predicted by the early processing measures of the context. Perception of traumatic cues in neutral contexts is biased in PTSD at early processing stages and contributes significantly to the impairment in context-relational memories. For trauma-unrelated cues and contexts no significant differences emerged between PTSD and trauma-exposed as well as non-trauma-exposed controls. Treatments for individuals diagnosed with PTSD should focus on early processing, perception and attention of cue/context traumatic associations in addition to contextual memory.
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Affiliation(s)
- Francesca Zidda
- Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
| | - Frauke Steiger-White
- Faculty for Social Sciences, Department of Clinical and Biological Psychology and Psychotherapy, University of Mannheim, Mannheim, Germany
| | - Tobias Winkelmann
- Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
| | - Michaela Ruttorf
- Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
- Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
| | - Jamila Andoh
- Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
| | - Frauke Nees
- Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig- Holstein, Kiel University, Kiel, Germany
| | - Herta Flor
- Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
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12
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Moriya J. Enhanced long-term memory for distractors via attention in trait and social anxiety. ANXIETY, STRESS, AND COPING 2025:1-16. [PMID: 40326677 DOI: 10.1080/10615806.2025.2500746] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/16/2024] [Revised: 04/23/2025] [Accepted: 04/24/2025] [Indexed: 05/07/2025]
Abstract
Individuals with anxiety and social anxiety direct their attention toward emotionally neutral task-irrelevant distractors. However, what happens after attention is paid to neutral distractors remains unknown. This study examined whether attention to distractors enhances long-term memory (LTM) of distractors in individuals with anxiety and social anxiety. Participants performed a visual-search task using real-world objects under either anxiety induction (Experiment 1) or no anxiety induction (Experiment 2). Subsequently, in the surprise-recognition task, participants were required to indicate whether an object had been shown in the visual-search task. The results showed that anxiety and social anxiety, especially the fear of negative evaluation, positively correlated with attentional bias toward neutral distractors. Moreover, mediation analysis showed significant indirect effects of anxiety and social anxiety on LTM through attentional bias. These results suggest that individuals with anxiety and social anxiety involuntarily direct their attention to distractors, which enhances their LTM.
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Affiliation(s)
- Jun Moriya
- Faculty of Sociology, Kansai University, Suita, Japan
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13
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Sikki M, Konikkou K, Kostantinou N, Fanti KA. Testing the effectiveness of combined attention modification training with right dorso-lateral prefrontal cortex theta-burst stimulation on reducing levels of anxiety and attentional bias. Exp Brain Res 2025; 243:137. [PMID: 40320453 PMCID: PMC12050235 DOI: 10.1007/s00221-025-07040-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Accepted: 02/24/2025] [Indexed: 05/08/2025]
Abstract
Neurostimulation techniques, such as continuous theta-burst stimulation (cTBS), over the dorsolateral prefrontal cortex (DLPFC) have been associated with improvements in anxiety symptoms and emotion processing. The aim of this feasibility study was the evaluation of the effectiveness of cTBS over the right DLPFC combined with Attention Modification Training (AMT) on reducing levels of anxiety and attentional bias. A 40s-cTBS session (real or sham) over the right DLPFC was administrated at 8 treatment sessions over a 2-week period, and each cTBS treatment was followed by computer-based AMT (real or control). Eighty-nine participants (Mage = 21.29, SD = 2.06, 50.56% females) differentiated on levels of anxiety were randomly assigned to the following treatment groups (i) cTBS and AMT, (ii) cTBS and control AMT, and (iii) sham cTBS and AMT. Findings suggested that cTBS combined with AMT treatment was not superior to sham cTBS and AMT on reducing self-reported anxiety symptoms. However, combined cTBS and AMT was associated with increased attention towards positive stimuli and increased gaze fixation in the mouth region of happy facial expressions. Current results provide promising evidence for the effectiveness of AMT in reducing anxiety symptoms and contribute to existing knowledge on how inhibitory stimulation over the right DLPFC combined with AMT may influence emotion processing. Present findings can inform future treatments designed to address the attention mechanisms leading to anxiety symptoms.
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14
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Spalding DM, Hart R, Henderson R, Nicholls LAB. Age moderates associations between dementia worry and subjective cognition. Cogn Emot 2025; 39:505-523. [PMID: 38973175 DOI: 10.1080/02699931.2024.2371095] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/27/2023] [Revised: 06/14/2024] [Accepted: 06/17/2024] [Indexed: 07/09/2024]
Abstract
The present study assessed whether dementia worry is associated with adults' subjective cognitive difficulties, and whether any associations are moderated by age. Participants were 477 adults aged 18-90 years. They completed standard, subjective measures of dementia worry and everyday cognitive difficulties (i.e. attention, language, verbal and visual-spatial memory, and visual-perceptual ability). Moderated regression analyses included dementia worry as a predictor of specific cognitive difficulties, and age as a moderator. Covariates included gender, trait cognitive and somatic anxiety, general aging-related anxiety, depression, stress, mental health treatment status, and health status. Greater overall dementia worry, and specifically more frequent dementia worry, were both associated with greater attentional difficulty in middle-aged and older adults, but not in young adults. Cognitions about developing dementia in reaction to memory lapses were also associated with greater cognitive difficulties across the adult lifespan for multiple cognitive domains. Results highlight a robust relationship between dementia worry and subjective attentional difficulties, especially in middle-aged and older adults. Worry frequency is also more influential with adult aging. A cognitive or meta-cognitive mechanism may underlie subjective cognitive concerns across the adult lifespan.
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Affiliation(s)
- David M Spalding
- Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK
| | - Rebecca Hart
- Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK
| | - Robyn Henderson
- Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK
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15
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Karayağız Muslu G, Manav G, Nazik F. Turkish validity and reliability study of the parental cognitive perception inventory on the effects of disasters on children's well-being (PCP-DCWB). J Pediatr Nurs 2025; 82:e57-e64. [PMID: 40157865 DOI: 10.1016/j.pedn.2025.03.018] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Revised: 03/18/2025] [Accepted: 03/22/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND Natural disasters have a devastating impact on children. Parents' perception and awareness of the symptoms of mental disorders in children following a disaster event is an important element for early diagnosis and treatment. The study focused on developing the Turkish version of the Parents' Cognitive Perception Inventory on the Effects of Disasters on Children's Well-Being (PCP-DCWB-TR), ensuring cultural and linguistic adaptation and maintaining its reliability and validity. METHOD A methodological approach was adopted, and 213 parents were included in the study. Data collection was conducted online between March and June 2023 using the Socio-Demographic Characteristics Questionnaire and the PCP-DCWB-TR. Statistical analysis included descriptive statistics, and reliability was assessed using Cronbach's alpha, test-retest, and item-total score analysis. RESULTS Exploratory and confirmatory factor analyses were conducted and revealed 16 items in two subscales, explaining 55.43 % of the total variance. The scale showed high reliability with a Cronbach's alpha of 0.89, while confirmatory factor analysis confirmed the model with a mean error of approximation of 0.080. Test-retest results showed a strong correlation (Pearson correlation 0.78, p < 0.001). CONCLUSION The adapted PCP-DCWB-TR is a valid and reliable instrument for assessing parents' cognitive perceptions of the impact of disasters on children's well-being in the context of Turkish society. PRACTICE IMPLICATIONS All healthcare professionals can use this scale in interventional studies aiming at assessing parents' cognitive perceptions of the impact of disasters on children's well-being.
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Affiliation(s)
- Gonca Karayağız Muslu
- Muğla Sıtkı Koçman University Fethiye Faculty of Health Sciences, Pediatric Nursing Department, Muğla, Turkey.
| | - Gülay Manav
- Muğla Sıtkı Koçman University Faculty of Health Sciences, Pediatric Nursing Department, Muğla, Turkey.
| | - Feyza Nazik
- Bingöl University Faculty of Health Sciences, Nursing Department, Bingöl, Turkey.
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16
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Zheng P, Lyu Z. The impact of fear of pain on the temporal processing of emotional faces: modulation of attentional resources. Cogn Process 2025; 26:237-245. [PMID: 39499392 DOI: 10.1007/s10339-024-01243-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/01/2024] [Accepted: 10/23/2024] [Indexed: 11/07/2024]
Abstract
Recent research has focused on the spatial attention bias toward pain-related cues in individuals with fear of pain (FOP), but our understanding of its temporal attention features, particularly regarding emotional faces, is limited. To address this gap, 39 individuals with high fear of pain (H-FOP) and 37 with low fear of pain (L-FOP) completed a rapid serial visual presentation dual task. Participants viewed a series of rapidly presented pictures, first identified neutral building images as the first target (T1) and then emotional faces (painful, neutral, and happy) as the second target (T2). T1 and T2 presented at time intervals of 232 ms (lag 2) and 696 ms (lag 6), respectively. Results indicate that H-FOP group members were less accurate in recognizing faces at lag 2 shortly after correctly identifying T1 compared to those L-FOP group members. Notably, all participants were more accurate in recognizing painful faces at lag 2 than in identifying neutral and happy faces, suggesting a negative bias toward pain stimuli when attentional resources were limited. In contrast, at lag 6, when attentional resources were more abundant, participants showed greater accuracy in recognizing neutral faces than emotional faces. These findings underscore the influence of fear of pain and available cognitive resources on the attentional processing of emotional faces over time, providing insights into how fear of pain affects the temporal dynamics of emotional face recognition and the role of attentional resources.
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Affiliation(s)
- Panpan Zheng
- School of Educational Science, Yangzhou University, Yangzhou, 225000, Jiangsu, China
| | - Zhenyong Lyu
- School of Educational Science, Yangzhou University, Yangzhou, 225000, Jiangsu, China.
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17
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Yin F, Si F, Huo S, Wang Z, Yang H, Zhao X, Cao J. Social anxiety modulating early processing for social threat words: an ERP study. Cogn Emot 2025; 39:603-613. [PMID: 39046729 DOI: 10.1080/02699931.2024.2381660] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Revised: 06/14/2024] [Accepted: 07/11/2024] [Indexed: 07/25/2024]
Abstract
Even though some recent research revealed individuals with HSA typically display enhanced processing in the early stages of emotional information processing due to hypervigilance and vulnerability to negative stimuli, it is still unclear whether social anxiety affects the time course underlying processing bias for emotional stimuli. Therefore, the present study aimed to explore the early stage of processing social threat stimuli in high social anxiety (HSA) individuals by recording RTs and EEG data in the emotional Stroop task. Behavioral data showed that the HSA group responded to the threat words faster than neutral words (i.e. negative bias), but no emotional effects in the low social anxiety (LSA) group. Although the P1 component did not show any early effects, ERP data exhibited an enhanced N170 for HSA than for LSA groups. Threat words elicited larger N170 than neutral words in the LSA group only; this emotion effect was not evident in the HSA group. These findings indicated that social anxiety modulates early processing for social threat words. This study revealed the neural mechanisms underlying early emotional processing in individuals with social anxiety, providing insights for the evaluation and intervention of social anxiety.
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Affiliation(s)
- Fei Yin
- Department of Nursing, Harbin Medical University, Daqing, People's Republic of China
| | - Feng Si
- Key Laboratory of Human Factors and Ergonomics for State Market Regulation, China National Institute of Standardization, Beijing, People's Republic of China
| | - Shuhui Huo
- Department of Nursing, Harbin Medical University, Daqing, People's Republic of China
| | - Zhengjun Wang
- Department of Nursing, Harbin Medical University, Daqing, People's Republic of China
| | - Haibo Yang
- Department of Psychology, Daqing Third Hospital, Daqing, People's Republic of China
| | - Xiwu Zhao
- Department of Psychology, Daqing Third Hospital, Daqing, People's Republic of China
| | - Jianqin Cao
- Department of Nursing, Harbin Medical University, Daqing, People's Republic of China
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18
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Esterman M, Agnoli S, Evans TC, Jagger-Rickels A, Rothlein D, Guida C, Hughes C, DeGutis J. Characterizing the effects of emotional distraction on sustained attention and subsequent memory: A novel emotional gradual onset continuous performance task. Behav Res Methods 2025; 57:141. [PMID: 40216687 DOI: 10.3758/s13428-025-02641-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 02/24/2025] [Indexed: 04/24/2025]
Abstract
This study examines the impact of emotional distraction on sustained attention using a novel gradual onset continuous performance task (gradCPT). Sustained attention is a foundational cognitive process, vulnerable to both internal (endogenous) and external (exogenous) disruptions. Reliable, validated paradigms to assess internal sources of variation in sustained attention have been used to characterize basic aspects of attention as well as individual differences and neurobiological mechanisms. However, sustained attention can also be disrupted by external distraction, especially highly salient distractors, due to their affective and/or arousing nature. Markedly less work has been conducted to develop reliable and validated paradigms to study these effects on sustained attention. This study introduces a novel task, the emogradCPT, to characterize the impact of emotional distractors (background images) on the ability to sustain attention during an emotionally neutral task (digit discrimination task). Across two experiments and three rounds of data collection, we demonstrate that emotionally negative distractors robustly and reliably disrupt ongoing ability to sustain attention, reflected in reduced accuracy, and slower RTs, relative to neutral, positive, and no distractor conditions. Further, we validated the task by correlating objective and subjective measures of distraction, as well as demonstrating the impact of these distractors on downstream memory encoding and affect. Making these data and tools publicly available, we encourage the use of this paradigm to inform future basic, clinical, and neuroimaging studies of affective interactions with ongoing goal-directed attentional processes.
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Affiliation(s)
- Michael Esterman
- National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA.
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA.
- Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
| | - Sam Agnoli
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
| | - Travis C Evans
- National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
- Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA
- Department of Psychological Sciences, Auburn University, Auburn, AL, USA
| | - Audreyana Jagger-Rickels
- National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
- Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA
| | - David Rothlein
- National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
| | - Courtney Guida
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
- Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA
| | - Carrie Hughes
- National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA, 02130, USA
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
| | - Joseph DeGutis
- Boston Attention and Learning Lab (BALLAB), VA Boston Healthcare System, Boston, MA, USA
- Department of Psychiatry, Harvard Medical School, Boston, MA, USA
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19
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Xue X, Pourtois G. Neurophysiological evidence for emotional attention modulation depending on goal relevance. Sci Rep 2025; 15:12045. [PMID: 40199937 PMCID: PMC11978912 DOI: 10.1038/s41598-025-96537-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2024] [Accepted: 03/28/2025] [Indexed: 04/10/2025] Open
Abstract
Although threat-related stimuli can capture attention automatically, recent findings have challenged this assumption by showing that goal rather than threat can be prioritized and eventually guide attentional control. In this study, we used high density electroencephalography (EEG) in 40 participants while peripheral emotional faces (either fear or happiness) were either goal-relevant or irrelevant during a dot-probe task (DPT). The use of peripheral vision was established by eye-tracking. Both the face specific N170 component and the subsequent Early Posterior Negativity (EPN) were enhanced by fear at the cue level, yet the latter one only when fear was goal relevant. Importantly, we found that early on following target onset at the P1 level, both value and goal relevance drove spatial attention and interacted with each other such that when they were goal-relevant, fearful faces captured attention less than when they were not. These results suggest that emotional attention is flexible and it can be influenced by the goal relevance of emotion. Moreover, they shed light on the electrophysiological manifestations of this flexibility and dovetail with the assumption that sensory gain control effects occurring in the visual cortex depending on attentional control are multiplexed and determined by both value and goal.
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Affiliation(s)
- Xiaojuan Xue
- Cognitive & Affective Psychophysiology Laboratory, Department of Experimental Clinical & Health Psychology, Ghent University, Henri Dunantlaan 2, 9000, Ghent, Belgium.
| | - Gilles Pourtois
- Cognitive & Affective Psychophysiology Laboratory, Department of Experimental Clinical & Health Psychology, Ghent University, Henri Dunantlaan 2, 9000, Ghent, Belgium
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20
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Sharma Y, Jalalian P, Caughey S, Golubickis M, Macrae CN. Faces displaying dominance and trustworthiness do not automatically capture attention. Q J Exp Psychol (Hove) 2025:17470218251334082. [PMID: 40171998 DOI: 10.1177/17470218251334082] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/04/2025]
Abstract
Contesting the viewpoint that personality impressions are spontaneously extracted from triggering facial cues, recent research suggests that such inferences emerge only when instructions are given to judge individuals in terms of the trait characteristics of interest. Notwithstanding this demonstration, however, it is possible that faces displaying fundamental character traits may exert influence over lower-level aspects of cognition that precede-and serve as the foundation for-impression formation. For example, paralleling work on emotional expressions, faces conveying important traits may automatically attract attentional resources. Accordingly, employing a dot-probe task, the current research explored whether faces varying in dominance (Experiments 1 & 2) and trustworthiness (Experiment 3) trigger attentional capture. The results were consistent across all three experiments. Using both naturalistic and computer-generated faces of women and men, neither dominance nor trustworthiness captured attention. The theoretical implications of these findings are considered.
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Affiliation(s)
- Yadvi Sharma
- School of Psychology, University of Aberdeen, Aberdeen, UK
| | | | - Siobhan Caughey
- Alliance Manchester Business School, University of Manchester, Manchester, UK
| | | | - C Neil Macrae
- School of Psychology, University of Aberdeen, Aberdeen, UK
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21
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de Rutte J, Myruski S, Davis E, Findley A, Dennis-Tiwary TA. A randomized clinical trial investigating the clinical impact of a game-based digital therapeutic for social anxiety disorder. J Anxiety Disord 2025; 111:103000. [PMID: 40068434 DOI: 10.1016/j.janxdis.2025.103000] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Revised: 03/04/2025] [Accepted: 03/04/2025] [Indexed: 04/12/2025]
Abstract
The objective of this study was to determine if a novel game-based digital therapeutic intervention reduced anxiety symptom severity in adults with clinically elevated symptoms of social anxiety disorder (SAD). Participants were randomly allocated (1:1) to receive four weeks of either the active intervention, a game-based form of attention bias modification (Active ABM) for anxiety, or the sham control training (Control). Between June 2022 to June 2023, 104 participants were enrolled with 93 completing the trial per-protocol and 104 included in the final intention-to-treat analysis (54 intervention, 50 control); mean age was 38.08 (10.56) years and 79 were female. The dependent variable was reduction in SAD symptoms, measured via the Liebowitz SAD Scale (LSAS). Participants were classified as having clinically elevated SAD symptoms only, or both SAD and Generalized Anxiety Disorder (GAD) symptoms (comorbid). The Active condition induced significantly greater reductions in SAD symptoms compared to the Control condition between Baseline and Post-Treatment [Active: M = -29.71, SD = 23.68; Control: M = -14.59, SD = 21.52, d = .67, t(102) = -3.40, p < .001] across the four-week study period. While no significant between-groups differences emerged at each timepoint individually, the Active condition induced significantly greater change over time in SAD symptoms compared to the Control condition. Use of this game-based digital ABM intervention showed benefits in the reduction of anxiety symptoms.
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Affiliation(s)
- Jennifer de Rutte
- Department of Psychology, The Graduate Center, City University of New York, USA; Department of Psychology, Hunter College, City University of New York, USA
| | - Sarah Myruski
- Department of Psychology, The Pennsylvania State University, USA
| | - Elizabeth Davis
- Department of Psychology, Hunter College, City University of New York, USA
| | - Abigail Findley
- Department of Psychology, The Graduate Center, City University of New York, USA; Department of Psychology, Hunter College, City University of New York, USA
| | - Tracy A Dennis-Tiwary
- Department of Psychology, The Graduate Center, City University of New York, USA; Department of Psychology, Hunter College, City University of New York, USA.
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22
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Burns H, Hurst A, Garay P, Murray NE, Stewart SH, Mejia J, Bagnell A, Klein RM, Meier S. Attentional biases for dynamic stimuli in emerging adults with anxiety: A preliminary eye-tracking study. J Psychiatr Res 2025; 184:262-271. [PMID: 40069991 DOI: 10.1016/j.jpsychires.2025.02.046] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/03/2024] [Revised: 02/21/2025] [Accepted: 02/24/2025] [Indexed: 04/09/2025]
Abstract
While attentional biases towards negative stimuli have previously been linked to the development and maintenance of anxiety disorders, a current limitation of this research involves the use of static images for stimuli, as they cannot adequately depict the dynamic nature of real-life interactions. Since attentional biases in those with elevated anxiety remain understudied using more naturalistic stimuli, such as dynamic social videos, the purpose of this explorative study was to use novel dynamic stimuli and modern eye-tracking equipment to further investigate negative attentional biases in anxious emerging, female adults. Non-clinical participants (N = 62; mean age = 20.44 years; biologically female) completed validated questionnaires regarding their anxiety symptoms and completed a free-viewing task by watching 30-s video clips while having their eye movements tracked. The video clips were shown in side-by-side pairs (i.e., positive-neutral, negative-neutral, and positive-negative) on a split screen without audio. Overall, participants fixated more quickly on emotional videos (i.e., positive and negative) over neutral ones, with more anxious participants orienting their gaze faster to the videos, regardless of content. Moreover, individuals with greater self-reported anxiety spent more time gazing at negative videos in negative-neutral pairings, highlighting that emerging female adults with increased anxiety symptoms may show a negative attention bias when viewing social interactions. Importantly, by incorporating novel, dynamic stimuli, we expand upon prior research on attentional biases, with the potential to adapt this approach for novel interventions that may ultimately help those suffering from anxiety.
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Affiliation(s)
- Hailey Burns
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
| | - Austin Hurst
- Laboratory for Brain Recovery and Function, School of Physiotherapy, Dalhousie University, Halifax, NS, Canada; Faculty of Health, Dalhousie University, Halifax, NS, Canada
| | - Pristine Garay
- Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada
| | | | - Sherry H Stewart
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada; Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada
| | - Jose Mejia
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
| | - Alexa Bagnell
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
| | - Raymond M Klein
- Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada; Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada
| | - Sandra Meier
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
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23
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Howarth E, Witham C, Bethell E. Does Measuring Social Attention Lead to Changes in Behavior? A Preliminary Investigation into the Implications of Attention Bias Trials on Behavior in Rhesus Macaques. J APPL ANIM WELF SCI 2025:1-14. [PMID: 40168257 DOI: 10.1080/10888705.2025.2486351] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/21/2024] [Accepted: 03/24/2025] [Indexed: 04/03/2025]
Abstract
A welfare assessment tool in development must satisfy several criteria before it is considered ready for general use. Some tools that meet many of these criteria have been criticized for their negative effect on welfare. We conducted a preliminary assessment of the impact of attention bias (AB) trials using threat-neutral conspecific face pairs followed by presumed neutral-positive filler stimuli on the behavior of 21 rhesus macaques (Macaca mulatta; 15 female). Behavioral observations were conducted following AB trials and repeated two weeks later when no AB trials had occurred (no trial: NT). The association between observation period and behavior was assessed using linear mixed-effects models in R. Trials did not impact any observed behavior except for fear, which was displayed by five monkeys over six trials (four NT). For this sample, there was a significant reduction in fear behavior following AB trials. We, therefore, found no evidence suggesting that AB trials negatively affect behaviour. AB protocols may be suitable for continued development for primate welfare assessment and we encourage researchers to include assessing test impact on welfare in their AB protocols.
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Affiliation(s)
- Emmeline Howarth
- Research Centre in Brain and Behaviour, School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool, UK
- School of Natural Sciences, University of Chester, Chester, UK
| | - Claire Witham
- Centre for Macaques, Harwell Institute, Medical Research Council, Salisbury, UK
| | - Emily Bethell
- School of Natural Sciences, University of Chester, Chester, UK
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24
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Boschet-Lange JM, Glück VM, Pittig R, Scherbaum S, Pittig A. Temporal dynamics of costly avoidance in anxiety disorders: Faster threat and weaker reward impact during approach-avoidance decisions in patients. J Anxiety Disord 2025; 111:103005. [PMID: 40086366 DOI: 10.1016/j.janxdis.2025.103005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/01/2024] [Revised: 02/17/2025] [Accepted: 03/07/2025] [Indexed: 03/16/2025]
Abstract
In anxiety disorders, approach-avoidance behavior is typically biased towards excessive, maladaptive avoidance despite costs and impairments (i.e., costly avoidance). Yet, little is known about the underlying decision dynamics that may contribute to such imbalanced behavior. The current study tested for altered temporal decision dynamics in patients with anxiety disorders compared to matched healthy controls in a task where avoiding an aversive stimulus conflicted with obtaining rewards. Participants chose repeatedly between a fixed safe/low reward and a threat/high reward option with varying threat (probability of an aversive stimulus presentation) and reward information (reward magnitude). Structured computer mouse movements required for choosing between options were tracked to capture the temporal dynamics of the decision process (i.e., when and how strongly threat and reward information influenced decision preference). The current study replicated elevated costly threat avoidance in patients with anxiety disorders compared to matched controls. Importantly, time-continuous multiple regression of mouse movements revealed altered temporal dynamics: patients showed a faster (but not stronger) impact of threat and a weaker impact of competing rewards. These findings highlight that not only biases in threat processes but also competing rewards may guide excessive avoidance and could be important treatment targets in anxiety disorders. Future research may support the external validity of these findings in real-life decisions and try to identify therapeutic strategies that allow to specifically target the attenuated impact of rewards and the accelerated impact of threat in patients.
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Affiliation(s)
- Juliane M Boschet-Lange
- Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany
| | - Valentina M Glück
- Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany
| | - Roxana Pittig
- Translational Psychotherapy, Institute of Psychology, University of Göttingen, Göttingen, Germany
| | - Stefan Scherbaum
- Department of Psychology, Technische Universität Dresden, Dresden, Germany
| | - Andre Pittig
- Translational Psychotherapy, Institute of Psychology, University of Göttingen, Göttingen, Germany.
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25
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Yao S, Kendrick KM. How does oxytocin modulate human behavior? Mol Psychiatry 2025; 30:1639-1651. [PMID: 39827220 DOI: 10.1038/s41380-025-02898-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/02/2024] [Revised: 12/19/2024] [Accepted: 01/14/2025] [Indexed: 01/22/2025]
Abstract
While the highly evolutionarily conserved hypothalamic neuropeptide, oxytocin (OT) can influence cognitive, emotional and social functions, and may have therapeutic potential in disorders with social dysfunction, it is still unclear how it acts. Here, we review the most established findings in both animal model and human studies regarding stimuli which evoke OT release, its primary functional effects and the mechanisms whereby exogenous administration influences brain and behavior. We also review progress on whether OT administration can improve social symptoms in autism spectrum disorder and schizophrenia and consider possible impediments to translational success. Importantly, we emphasize that OT acting via its extensive central or peripheral receptors primarily influences behavior indirectly through neuromodulatory interactions with classical transmitters and other peptides which themselves can independently influence behavior. We also emphasize that exogenous administration studies increasingly demonstrate peripheral effects of OT may be of greater importance than originally thought, especially involving the vagus. Overall, we propose a hierarchical model whereby OT's neuromodulatory actions influence behavior across interconnected functional domains and ultimately help to promote survival, security and sociability. Initially, OT potently facilitates attention to salient social and other important stimuli and additionally modulates cognitive, emotional and reward processing in a person- and context-dependent manner to promote interpersonal social understanding, attraction and bonds on the one hand and social group cohesion through increased conformity, altruistic punishment and moral emotions on the other. OT also increases co-operation and protection across both social domains. We hope this review and model will promote further research and help aid future translation success.
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Affiliation(s)
- Shuxia Yao
- The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.
| | - Keith M Kendrick
- The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.
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26
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Thyagaraj Y, Topel S, Charpentier CJ. Biased information-seeking and information-integration in social anxiety. Curr Opin Psychol 2025; 62:102002. [PMID: 39923410 DOI: 10.1016/j.copsyc.2025.102002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/14/2024] [Revised: 11/08/2024] [Accepted: 01/24/2025] [Indexed: 02/11/2025]
Abstract
Social anxiety is associated with an intense fear of social evaluation and rejection, often leading to avoidance behaviors and distress. In this review, we summarize the current understanding of how various cognitive biases may lead to the development and maintenance of social anxiety. While early models of social anxiety have focused on negative biases in perception, attention, memory and emotion regulation, more recent literature has started to characterize biases in information-seeking and information-integration, especially in the context of self-referential information and social feedback. We also highlight directions for future work, including characterizing how different biases in social anxiety relate to each other, and how they may help dissociate social anxiety symptoms from co-occurring conditions such as generalized anxiety and depression.
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Affiliation(s)
- Yukta Thyagaraj
- Undergraduate Program, Indian Institute of Science, Bangalore, Karnataka, India; Department of Psychology, University of Maryland, College Park, MD, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA
| | - Selin Topel
- Institute of Psychology, Leiden University, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands
| | - Caroline J Charpentier
- Department of Psychology, University of Maryland, College Park, MD, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA; Brain and Behavior Institute, University of Maryland, College Park, MD, USA.
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27
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Mizrahi D, Laufer I, Zuckerman I. Attachment Style, Task Difficulty, and Feedback Type: Effects on Cognitive Load. Behav Sci (Basel) 2025; 15:427. [PMID: 40282049 PMCID: PMC12024011 DOI: 10.3390/bs15040427] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2025] [Revised: 03/20/2025] [Accepted: 03/25/2025] [Indexed: 04/29/2025] Open
Abstract
This study examines how attachment styles influence cognitive load during a dot counting task with varying difficulty levels and feedback types. From an initial pool of 96 participants, 27 were selected based on attachment classifications from the Experiences in Close Relationships-Revised (ECR-R) questionnaire. These participants completed the task while receiving personal and group-based feedback, and EEG recordings monitored cognitive load using the theta/beta ratio (TBR). Results show that negative personal feedback consistently elevated cognitive load across all attachment styles. Avoidant and fearful-avoidant individuals did not exhibit significant differences in cognitive load between positive and negative group feedback, suggesting a relatively stable response regardless of feedback valence. In contrast, securely attached individuals showed increased cognitive load under negative feedback conditions. Furthermore, individuals with higher attachment-related anxiety or avoidance experienced more pronounced increases in cognitive load as task difficulty increased. These findings suggest that attachment-related differences shape cognitive responses to feedback and task complexity level. The study highlights the role of adaptive feedback strategies in optimizing cognitive engagement across different attachment profiles.
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Affiliation(s)
- Dor Mizrahi
- Department of Industrial Engineering and Management, Ariel University, Ariel 4070000, Israel; (I.L.); (I.Z.)
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28
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Pacheco-Unguetti AP, Acosta A, Lupiáñez J. Characterizing the functioning of the attentional networks in state and trait anxiety: the role of affective information. Front Psychol 2025; 16:1539992. [PMID: 40181887 PMCID: PMC11966962 DOI: 10.3389/fpsyg.2025.1539992] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/05/2024] [Accepted: 02/26/2025] [Indexed: 04/05/2025] Open
Abstract
Introduction The aim of the present research was to examine the role of affective information in the functioning of attentional networks in individuals with high vs. low trait or state anxiety. Previous studies suggest that anxiety can influence attentional processes, but the impact of affective information, such as alerting emotional stimuli, on these attentional networks remains unclear. Methods We conducted a set of experiments using negative or neutral faces as alerting stimuli, presented either alone or together with a neutral sound, within a modified version of the Attention Network Test-Interactions (ANT-I). Additionally, data from previous experiments with similar anxiety groups and without affective manipulations of alertness were analyzed for comparative insights (378 participants in total). Results Results showed three main effects on the functioning of attentional networks when affective alerting signals were introduced: (1) the alertness effect is increased, (2) the interference effect is increased, and (3) the orienting effect is decreased. These effects occurred regardless of the valence of the alerting stimuli on a given trial. Importantly, the presence of affective information on some trials eliminated the group differences regarding the functioning of the attentional networks that are usually found when no affective information is presented. Specifically, the larger interference effect commonly observed in individuals with high trait-anxiety and the larger alertness and orienting effects seen in those with high state-anxiety, disappeared when emotional alerting stimuli were included. Discussion The findings suggest that emotional information can significantly impact the functioning of attentional networks, particularly in relation to anxiety. The presence of affective stimuli seems to modulate attentional biases associated with anxiety, potentially neutralizing the usual effects seen in individuals with high trait or state anxiety. The role of affective information on the functioning of the attentional networks is discussed within the framework of anxiety and attention.
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Affiliation(s)
- Antonia Pilar Pacheco-Unguetti
- Department of Personality, Assessment, and Psychological Treatment, University of Granada, Granada, Spain
- Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain
| | - Alberto Acosta
- Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain
- Department of Experimental Psychology, University of Granada, Granada, Spain
| | - Juan Lupiáñez
- Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain
- Department of Experimental Psychology, University of Granada, Granada, Spain
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Marino CE, Rjabtsenkov P, Sharp C, Ali Z, Pineda E, Bavdekar SY, Garg T, Jordan K, Halvorsen M, Aponte C, Blue J, Zhu X, Suarez-Jimenez B. Using virtual reality to study spatial mapping and threat learning. NPJ SCIENCE OF LEARNING 2025; 10:14. [PMID: 40089531 PMCID: PMC11910644 DOI: 10.1038/s41539-025-00305-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/23/2024] [Accepted: 02/24/2025] [Indexed: 03/17/2025]
Abstract
Using spatial mapping processes to discriminate between threat and safety is crucial for survival. Little is known why some fail to discriminate during contextual conditioning. We used a virtual reality (VR) contextual conditioning paradigm to elucidate the effects of state and trait anxiety on contextual threat learning. Participants (n = 70) "picked" flowers in a VR environment. Dangerous zone flowers predicted an electric shock, while safe zone flowers did not. Between trials, participants completed a spatial memory task. Galvanic skin response (GSR) and State Trait Anxiety Inventory scores were recorded. Participants were considered learners for correctly identifying both zones. Non-learners, compared to learners, performed worse during the spatial memory task and demonstrated higher state anxiety scores and GSR. Learners showed higher skin conductance response (SCR) in the dangerous compared to the safe zone, while non-learners showed no SCR differences between zones. Results indicate state anxiety may impair spatial mapping, disrupting contextual threat learning.
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Affiliation(s)
- Claire E Marino
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Pavel Rjabtsenkov
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Caitlin Sharp
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Zonia Ali
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Evelyn Pineda
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Shreya Y Bavdekar
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Tanya Garg
- Department of Psychology, University of Rochester, Rochester, NY, USA
| | - Kendal Jordan
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Mary Halvorsen
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Carlos Aponte
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Julie Blue
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
| | - Xi Zhu
- Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA
- New York State Psychiatric Institute, New York, NY, USA
| | - Benjamin Suarez-Jimenez
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
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30
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Fortes PP, Dos Santos-Ribeiro S, de Salles-Andrade JB, Moreira-de-Oliveira ME, de Abreu-Cervone F, de Faro LFT, de Melo-Fadel BTM, de Menezes GB, Fontenelle LF. Mindfulness interventions and quality of life in anxiety-related disorders: A systematic review and meta-analysis. J Affect Disord 2025; 373:383-393. [PMID: 39740743 DOI: 10.1016/j.jad.2024.12.103] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/30/2024] [Revised: 11/20/2024] [Accepted: 12/27/2024] [Indexed: 01/02/2025]
Abstract
Mindfulness-based interventions (MBIs) effectively treat anxiety symptoms across different anxiety and related disorders (ARDs), including panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. In this systematic review and meta-analysis, we investigate whether MBIs also lead to improvements in the quality of life (QoL) of patients with ARDs. A systematic review was performed through electronic search in PUBMED, PsycINFO, Embase, Web of Science, and Clinical Trials databases. The inclusion criteria comprised randomized controlled trials (RCTs) investigating individuals diagnosed with ARDs who underwent MBIs with QoL as an outcome. The review included 15 RCTs, encompassing 1.465 participants. Broadly speaking, we found that MBIs were more effective than control groups in improving QoL for individuals with ARDs (Standardized Mean Difference, SDM = 0.175, 95 % CI 0.048 to 0.303). Upon classifying studies by control group types, MBIs demonstrated greater effectiveness than non-gold standard interventions (SDM = 0.213, 95 % CI 0.053 to 0.372). Notably, no significant difference was found between MBIs and gold standard interventions (SDM = 0.061, 95 % CI -0.175 to 0.297). MBIs may effectively improve QoL in individuals with ARDs. Further studies with larger samples are needed for more robust conclusions.
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Affiliation(s)
- Pedro P Fortes
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | - Samara Dos Santos-Ribeiro
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
| | | | - Maria E Moreira-de-Oliveira
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | - Flávia de Abreu-Cervone
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | - Livi F T de Faro
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | - Bianca T M de Melo-Fadel
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | - Gabriela B de Menezes
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, Brazil
| | - Leonardo F Fontenelle
- Anxiety, Obsessions and Compulsions Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, Brazil; Department of Psychiatry, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia
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31
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Nie P, Wang T, Wu Q, Chen W, Shen F, Huang L, Dong X. Attention Deficits in Migraine: Mismatch Negativity and P3a in an Event-Related Potential Study. J Pain Res 2025; 18:1161-1171. [PMID: 40092720 PMCID: PMC11908398 DOI: 10.2147/jpr.s506708] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/15/2024] [Accepted: 02/28/2025] [Indexed: 03/19/2025] Open
Abstract
Purpose Attention performance in chronic migraine remains unclear. The present study aimed to explore the pre-attentive detection and attention orienting ability in individuals with chronic migraine (CM) measured by mismatch negativity (MMN) and P3a components and assess their associations with migraine characteristics. Methods This cross-sectional observational study recruited 25 individuals with episodic migraine (EM), 25 individuals with CM and 25 healthy controls (HC) matched for age, sex, and educational level. The MMN and P3a components were measured using event-related potential (ERPs) tools with auditory oddball paradigms and migraine characteristics were collected. Results Individuals with CM exhibited a longer MMN latency (p = 0.010) and a lower P3a amplitude than HC (p = 0.004) and EM (p = 0.002). Correlation analysis showed that P3a amplitude was negatively correlated with headache attack frequency and the Migraine Disability Assessment Scale (MIDAS), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD) scores. Conclusion Individuals with CM showed deficits in pre-attentive detection and attention orientation. Moreover, attention-oriented dysfunction is associated with headache attack frequency, headache-related disability, anxiety and depression.
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Affiliation(s)
- Ping Nie
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
| | - Teng Wang
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
| | - Qian Wu
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
| | - Weikai Chen
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
- Department of Neurology, The Third Hospital of Xiamen, Xiamen, 361000, People’s Republic of China
| | - Feifei Shen
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
| | - Lin Huang
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
| | - Xin Dong
- Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China
- Department of Neurosurgery, Chongqing Hospital of Jiangsu Province Hospital, Chongqing, 401420, People’s Republic of China
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Cuder A, Doz E, Rubinsten O, Passolunghi MC, Pellizzoni S. Attentional bias and math avoidance: insights from a developmental sample. PSYCHOLOGICAL RESEARCH 2025; 89:62. [PMID: 40167773 PMCID: PMC11961517 DOI: 10.1007/s00426-025-02089-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2024] [Accepted: 02/09/2025] [Indexed: 04/02/2025]
Abstract
Stimuli perceived as threatening subtly influence how individuals orient their attention, a phenomenon labelled as attentional bias. According to literature, individuals with negatives attitudes toward math would exhibit attentional bias when presented with math-related stimuli. However, attentional bias and its relationships with math anxiety, math self-efficacy, and math skills are understudied, particularly when considering developmental samples. For this reason, the aim of the present study was to assess attentional bias toward math stimuli (i.e., math vs. neutral words) and to evaluate its relationship with math anxiety, math self-efficacy and math skills in fifth and sixth grade students (Mmonths = 135.84; SDmonths = 7.53) tested in January 2023. Findings indicated that children who were more anxious and had lower levels of math self-efficacy and math skills appeared to avoid math stimuli in an attentional bias task. Furthermore, dominance analysis showed that math self-efficacy made the largest average contribution in attentional bias scores, suggesting that motivational constructs would play a central role in the observed attentional bias avoidance patterns. Results could potentially generalize developmental age samples, providing new insight into how avoidance behaviors, even for stimuli that are not purely numerical, would influence children's attentional processes rapidly and automatically, posing a risk factor for maintaining negative attitudes toward math.
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Affiliation(s)
- Alessandro Cuder
- Department of Life Sciences, University of Trieste, Via Weiss n. 21, Trieste, Italy
| | - Eleonora Doz
- Department of Life Sciences, University of Trieste, Via Weiss n. 21, Trieste, Italy
| | - Orly Rubinsten
- Department of Learning Disabilities, University of Haifa, Haifa, Israel
| | | | - Sandra Pellizzoni
- Department of Life Sciences, University of Trieste, Via Weiss n. 21, Trieste, Italy
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Stephenson AR, Stade EC, Ruscio AM. Measuring behavioral responses to a social stressor: Does the Social Performance Rating Scale have utility beyond social anxiety disorder? Behav Res Ther 2025; 186:104700. [PMID: 39923273 PMCID: PMC11924583 DOI: 10.1016/j.brat.2025.104700] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/15/2024] [Revised: 11/24/2024] [Accepted: 01/27/2025] [Indexed: 02/11/2025]
Abstract
The observer-rated Social Performance Rating Scale (SPRS) indexes anxious behaviors exhibited in social contexts. Although the SPRS has been used almost exclusively to study social anxiety disorder (SAD), other emotional disorders are also characterized by heightened responses to social stressors, hinting that the SPRS could serve as a transdiagnostic state measure of behavioral anxiety. To explore this possibility, adults with generalized anxiety disorder or major depressive disorder (n = 105) and adults with no psychopathology (n = 35) delivered a speech to a committee of mock behavioral experts. Behavioral anxiety observed during the speech was rated using the SPRS, then examined in relation to clinical and state measures of anxiety and depression. Contrary to our hypotheses, behavioral anxiety was not associated with clinician- or self-rated anxiety or depression severity. Instead, behavioral anxiety was heightened among individuals who specifically fear and avoid public speaking; who perceived the speech task to be more stressful; and who reported more emotional distress, somatic hyperarousal, and anxious and pessimistic thoughts at the time of the speech. The SPRS is a valid measure of anxious behavior in the many individuals, with and without SAD, who experience acute anxiety in social-evaluative contexts. As behavioral measures are resource-intensive to collect, research is needed to establish whether the SPRS predicts anxious behavior and functional impairment in real-world settings, over and above easier-to-obtain self-report measures.
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Jessup SC, Armstrong T, Hord CM, Dalmaijer ES, Olatunji BO. A multilevel examination of an inhibitory retrieval approach to exposure: Differentiating the unique and combined effects of multiple-context and multiple-stimulus cues. J Behav Ther Exp Psychiatry 2025; 86:101986. [PMID: 39178486 DOI: 10.1016/j.jbtep.2024.101986] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/25/2024] [Revised: 07/30/2024] [Accepted: 08/11/2024] [Indexed: 08/25/2024]
Abstract
BACKGROUND AND OBJECTIVES A proposed strategy for attenuating the return of fear is conducting exposure therapy in multiple contexts (e.g., different locations), which is believed to enhance the generalizability of safety learning. Although conducting exposure in multiple contexts can be differentiated from conducting exposure with multiple stimuli, the two strategies are often conflated. Furthermore, researchers have not yet determined whether one of these strategies, or a combination thereof, is most effective in attenuating fear renewal. METHODS Accordingly, the present treatment-analogue study examined the unique and combined effects of multiple-context and multiple-stimulus imagery-based exposure manipulations on threat expectancy, behavioral approach/anxiety, and attentional bias for threat over Zoom. Community adults (N = 134) who met diagnostic criteria for snake phobia were randomized to exposure to a single snake in multiple environmental contexts (MC), exposure to multiple snakes in a single environmental context (MS), or exposure to multiple snakes in multiple environmental contexts (MS/MC). RESULTS Results revealed significant reductions in threat expectancy and behavioral anxiety, but not attentional bias for threat in all three groups. However, behavioral approach declined over the course of exposure in the MS/MC condition but remained stable in the MC and MS conditions. There were no significant group differences in behavioral approach/anxiety or attentional bias at a one-week follow-up. However, participants in the MC condition reported lower threat expectancy at a one-week follow-up than the other groups and this group difference was partially mediated by lower mean distress during exposure. CONCLUSIONS Implications of these findings for the inhibitory retrieval theory are discussed.
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Xu I, Passell E, Strong RW, Grinspoon E, Jung L, Wilmer JB, Germine LT. No Evidence of Reliability Across 36 Variations of the Emotional Dot-Probe Task in 9,600 Participants. Clin Psychol Sci 2025; 13:261-277. [PMID: 40151297 PMCID: PMC11949442 DOI: 10.1177/21677026241253826] [Citation(s) in RCA: 4] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 03/29/2025]
Abstract
The emotional dot-probe task is a widely used measure of attentional bias to threat. Recent work suggests, however, that subtraction-based behavioral measures of emotional dot-probe performance may not be appropriate for measuring such attentional biases due to poor reliability. In the two current studies, we systematically tested thirty-six versions of the emotional dot-probe that varied in stimuli (faces, scenes, snakes/spiders), timings (stimulus onset asynchrony of 100, 500, 900 milliseconds), stimulus orientations (horizontal, vertical), and trial types (e.g., threat congruent and threat incongruent). Across 9,600 participants, none of the 36 versions demonstrated internal reliability greater than zero. Reliability was similarly poor in anxious participants (based on Generalized Anxiety Disorder 7 Items or Brief Hypervigilance Scale). We conclude that the standard behavioral scores (reaction time- or accuracy-based difference scores) derived from the emotional dot-probe are not adequately reliable measures of attentional biases to threat in anxious or nonanxious populations.
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Affiliation(s)
- Irene Xu
- Department of Psychology, University of Notre Dame, Notre Dame, IN, USA
| | - Eliza Passell
- Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
| | - Roger W. Strong
- Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
- Department of Psychiatry, Harvard Medical School, Boston, MA, USA
| | | | - Laneé Jung
- Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
| | | | - Laura T. Germine
- Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
- Department of Psychiatry, Harvard Medical School, Boston, MA, USA
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Vos LMW, Nieto I, Amanvermez Y, Smeets T, Everaert J. Do cognitive biases prospectively predict anxiety and depression? A multi-level meta-analysis of longitudinal studies. Clin Psychol Rev 2025; 116:102552. [PMID: 39923703 DOI: 10.1016/j.cpr.2025.102552] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2023] [Revised: 12/10/2024] [Accepted: 01/28/2025] [Indexed: 02/11/2025]
Abstract
Cognitive biases have been implicated in the etiology and maintenance of depression and anxiety, but their utility in predicting future symptoms remains debated. This meta-analysis aimed to estimate the overall effect size of their predictive effects and to identify moderators relevant to theory and methodology. The study protocol was pre-registered on PROSPERO (record number: CRD42021232236). Searches of PsycINFO, Web of Science, PubMed, PsyArXiv Preprints, and ProQuest Dissertations yielded 81 studies with 621 contrasts and 17,709 participants through December 2024. The methodological quality of the included studies was evaluated using the Quality In Prognosis Studies (QUIPS) tool. Results from a three-level meta-analysis revealed a small overall effect size (β = 0.04, 95 %-CI [0.02, 0.06], p < .001) and significant between- and within-study variance after removal of outliers. Equivalent effect sizes were found for the predictive utility of cognitive biases in children/adolescents and adults, for increased negative bias and decreased positive bias, and for anxiety and depression outcomes. The magnitude of the overall effect was moderated by the cognitive process, with significant effect sizes for interpretation bias and memory bias but not for attention bias. These findings support the predictive role of cognitive biases in anxiety and depression, with interpretation and memory biases emerging as key markers. These findings have implications for cognitive theories of depression and anxiety and for clinical interventions.
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Affiliation(s)
- Lisa M W Vos
- Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands
| | - Inés Nieto
- Department of Personality, Assessment, and Clinical Psychology, Complutense University of Madrid, Madrid, Spain
| | - Yağmur Amanvermez
- Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands
| | - Tom Smeets
- Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands
| | - Jonas Everaert
- Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands; Research Group of Quantitative Psychology and Individual Differences, KU Leuven, Leuven, Belgium.
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Yang S, Liu Y, Wang M, Zhao J. Interparental violence and children's attentional bias: The mediating effect of parental harsh discipline in China. CHILD ABUSE & NEGLECT 2025; 161:107296. [PMID: 39892273 DOI: 10.1016/j.chiabu.2025.107296] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/11/2023] [Revised: 12/15/2024] [Accepted: 01/22/2025] [Indexed: 02/03/2025]
Abstract
BACKGROUND It is a well-established fact that experiences of interparental violence (IPV) affect children's attentional bias. However, existing research has solely investigated the relations between IPV and children's attentional bias toward either negative (ANI) or positive information (API); little research has examined the distinct associations between IPV and such two types of attentional bias simultaneously. Moreover, parental harsh discipline may mediate above associations, but few studies have investigated this issue to date. OBJECTIVE This study examined the associations between IPV and children's attentional bias (including API and ANI) in the same model and the mediating roles of fathers' and mothers' harsh discipline-specifically, psychological aggression (PA) and corporal punishment (CP) in China. PARTICIPANTS AND SETTING A total of 505 Chinese elementary school students (Mage = 9.82 years; 51 % girls) and their parents participated in this study. METHODS Participants were asked to complete paper questionnaires measuring IPV, parental harsh discipline and children's attentional bias. Structural equation models were employed to test the mediating roles of parental harsh discipline in the associations between IPV and children's attentional bias. RESULTS IPV was positively related to children's ANI, while was negatively related to children's API. Additionally, IPV was related to higher level of ANI through the PA of fathers but lower level of API through that of mothers. Moreover, IPV was related to higher level of API through mothers' CP. CONCLUSIONS These findings suggest the linkage between IPV and children's attentional bias varies with the valence of information-positive or negative-and is differentially mediated by the harsh discipline of fathers and mothers within the Chinese cultural context.
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Affiliation(s)
- Shuya Yang
- Research Center for Child Development, College of Elementary Education, Capital Normal University, Beijing, PR China
| | - Yuan Liu
- Beijing Key Laboratory of Learning and Cognition, Research Center for Child Development, School of Psychology, Capital Normal University, Beijing, PR China
| | - Meifang Wang
- Research Center for Child Development, College of Elementary Education, Capital Normal University, Beijing, PR China.
| | - Jinxia Zhao
- Department of Education, Linyi University, Linyi, PR China
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Lee DS, Clement A, Grégoire L, Anderson BA. Aversive conditioning, anxiety, and the strategic control of attention. Cogn Emot 2025; 39:476-484. [PMID: 39431977 DOI: 10.1080/02699931.2024.2413360] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2024] [Revised: 06/21/2024] [Accepted: 10/01/2024] [Indexed: 10/22/2024]
Abstract
What we pay attention to is influenced by both reward learning and aversive conditioning. Although early attention tends to be biased toward aversively conditioned stimuli, sustained ignoring of such stimuli is also possible. How aversive conditioning influences how a person chooses to search, or the strategic control of attention, has not been explored. In the present study, participants learned an association between a colour and an aversive outcome during a training phase, and in a subsequent test phase searched for one of two targets presented on each trial; one target was rendered in the aversively conditioned colour (CS+) and the other in a neutral colour (CS-). Given the distribution of colour stimuli in the search array, it was more optimal to search for and report a target in one of the two colours on some trials. Our results demonstrate that participants were biased away from the CS+ target, which resulted in non-optimal search on some trials. Surprisingly, rather than accentuate this bias, greater state anxiety was associated with a stronger tendency to find and report the CS+ target. Our findings have implications for our understanding of the learning-dependent control of attention and abnormal attentional biases observed in high-anxious individuals.
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Affiliation(s)
- David S Lee
- Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA
| | - Andrew Clement
- Department of Psychology and Neuroscience, Millsaps College, Jackson, MI, USA
| | - Laurent Grégoire
- Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA
| | - Brian A Anderson
- Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA
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Ozturk S, Sussman TJ, Jin J, Serody MR, Imbriano G, Mohanty A. Perceptual Decision-Making Regarding Phylogenetically Salient Stimuli. AFFECTIVE SCIENCE 2025; 6:145-158. [PMID: 40094038 PMCID: PMC11904085 DOI: 10.1007/s42761-024-00271-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/08/2023] [Accepted: 08/23/2024] [Indexed: 03/19/2025]
Abstract
Phylogenetically salient stimuli such as spiders are commonly reported threats in the general population and the most common object of specific phobias in clinical populations. Several theories have hypothesized that our perceptual systems prioritize such stimuli in an "automatic" or "bottom-up" manner due to their evolutionary salience. However, empirical research on the perceptual processing of these stimuli as well as the influence of "top-down" goal-driven and bottom-up stimulus-driven factors is lacking. Here, we used perceptual psychophysics to determine absolute perceptual thresholds for the detection of spider and crab images. Subsequently, participants used spider and crab cues (that imposed a top-down perceptual set) to detect spiders and crab images presented at their predetermined perceptual threshold in a two-alternative forced-choice perceptual decision-making task. While spiders were detected at lower perceptual thresholds than crabs, they were not immune to top-down influence. Indeed, compared to top-down crab cues, spider cues improved the speed and accuracy of detection of spiders vs crabs. Using a hierarchical drift diffusion model, we found that spider cues biased decision-making not only by shifting the starting point of evidence accumulation towards the spider decision, but also by increasing the efficiency with which sensory evidence accumulated, more so for spider than crab perceptual decisions. Overall, these findings provide evidence for the perceptual prioritization of phylogenetically salient stimuli and highlight the computational mechanisms by which this prioritization is facilitated by bottom-up and top-down factors. Supplementary Information The online version contains supplementary material available at 10.1007/s42761-024-00271-z.
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Affiliation(s)
- Sekine Ozturk
- Department of Psychology, Stony Brook University, Stony Brook, NY USA
| | - Tamara J. Sussman
- Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY USA
| | - Jingwen Jin
- Department of Psychology, The University of Hong Kong, Hong Kong, SAR China
- State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, SAR China
| | - Megan R. Serody
- Department of Psychology, Stony Brook University, Stony Brook, NY USA
| | - Gabriella Imbriano
- Women’s Operational Military Exposure Network Center of Excellence (WOMEN COE), VA Palo Alto Health Care System, Palo Alto, CA USA
| | - Aprajita Mohanty
- Department of Psychology, Stony Brook University, Stony Brook, NY USA
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Möller S, Larsson A, Möttus A, Nordin G, Björkstrand J, Cervin M. No Biased Attention to Threat, Incompleteness, and Disgust in Youth with OCD and Anxiety Disorders. Res Child Adolesc Psychopathol 2025; 53:393-403. [PMID: 39760791 DOI: 10.1007/s10802-024-01282-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 12/10/2024] [Indexed: 01/07/2025]
Abstract
Obsessive-compulsive disorder (OCD) and anxiety disorders are early-onset mental disorders characterized by selective attention and strong emotional reactions. Attentional bias has been proposed to play a role in the development, onset, and maintenance of the disorders, but few studies have included youth with mental disorders, and no study has included more than one clinical group, making it unclear whether biased attention is disorder-specific or transdiagnostic in nature. In the present study, 65 youths with OCD (Mage = 13.6 [2.4], 57% girls), 52 youths with anxiety disorders (Mage = 14.5 [2.6] 83% girls), and 45 youths without a psychiatric disorder (Mage = 13.9 [3.1], 67% girls) completed a modified dot-probe task that included threat, incompleteness, and disgust cues. Contrary to our hypotheses, no group exhibited any attentional bias to any emotional cue, no group differences were present, and individual differences in attentional bias were not associated with individual differences in any symptom type. Disgust cues produced slower response times compared to the other emotional cues, but this effect was consistent across all type of trials and present in all three groups. In this study, no support for biased attention in treatment-seeking youth with OCD or anxiety disorders was found, which is in line with recent findings in adults using the dot-probe task. As attentional processes are clearly implicated in the clinical manifestation of these disorders, future research should try to better operationalize and measure relevant processes.
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Affiliation(s)
- S Möller
- Department of Psychology, Lund University, Lund, Sweden
| | - A Larsson
- Department of Psychology, Lund University, Lund, Sweden
| | - A Möttus
- Skåne Child and Adolescent Psychiatry, Research Unit, Lund, Sweden
| | - G Nordin
- Skåne Child and Adolescent Psychiatry, Research Unit, Lund, Sweden
| | - J Björkstrand
- Department of Psychology, Lund University, Lund, Sweden
| | - Matti Cervin
- Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
- Faculty of Medicine, Department of Clinical Sciences Lund Child and Adolescent Psychiatry, Lund University, Sofiavägen 2D, Lund, SE-22241, Sweden.
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Bina R, Levy D, Alfayumi-Zeadna S, Mesquita ARM, Costa R, Domínguez-Salas S, Wilson CA, Osorio A, Vousoura E, Uka A, Hancheva C, Contreras-García Y, Dikmen-Yildiz P, Christoforou A, Motrico E. Changes to social and healthcare providers support in the perinatal period: Impact on coping strategies, depression and anxiety. Midwifery 2025; 142:104295. [PMID: 39874648 DOI: 10.1016/j.midw.2025.104295] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/01/2024] [Revised: 11/24/2024] [Accepted: 01/13/2025] [Indexed: 01/30/2025]
Abstract
BACKGROUND During the perinatal period, risk of depression and anxiety (D&A) increases. As in other crisis events, the COVID-19 pandemic, imposed social distancing measures, diminished social support and changes in perinatal healthcare provision which heightened this risk. This study aimed to examine how changes in social and healthcare provider support during the pandemic affected coping strategies and depression and anxiety symptoms (D&As) among perinatal women. METHODS A cross-sectional international study included 7,368 pregnant and postpartum women up to six months postpartum from 12 countries (Albania, Brazil, Bulgaria, Chile, Cyprus, Greece, Israel, Malta, Portugal, Spain, Turkey, and the United Kingdom). Between June and October 2020, women answered an online survey regarding D&As (measured by the Edinburgh Postnatal Depression Scale and Generalized Anxiety Disorder-7), level of social and healthcare providers' support, changes to these types of support and coping strategies. RESULTS Main findings show that 24.6% of women had symptoms of depression and 20.2% of anxiety. Higher levels of D&A were associated with lower social and provider support, negative changes to social support and use of negative internal coping strategies. Positive coping strategies mediated the relationship between increased social and provider support and decreased D&As, while negative coping strategies mediated the relationship between negative changes to social support and increased D&As. CONCLUSION Social and provider support can promote coping strategies and reduce emotional distress. Healthcare providers should screen perinatal women for D&A, discuss ways to improve their coping strategies and social support as a preventive measure, and offer initial emotional well-being support.
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Affiliation(s)
- Rena Bina
- The Louis and Gabi Weisfeld School of Social Work, Bar Ilan University, Ramat Gan, Israel.
| | - Drorit Levy
- The Louis and Gabi Weisfeld School of Social Work, Bar Ilan University, Ramat Gan, Israel.
| | - Samira Alfayumi-Zeadna
- Nursing Department, School of Health Sciences, Ashkelon Academic College, Ashkelon 78211, Israel.
| | - Ana Raquel Marcelino Mesquita
- Escola de Psicologia - Centro de Investigação em Psicologia (CIPsi), Universidade do Minho, Braga, Portugal; ProChild CoLab Against Poverty and Social Exclusion - Association (ProChild CoLAB) Campus de Couros Rua de Vila Flor, 166, Guimarães 4810-225, Portugal.
| | - Raquel Costa
- EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas,n° 135, Porto 4050-600, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Rua das Taipas, n 135, Porto 4050-600, Portugal; Lusófona University, HEI-Lab: Digital Human-Environment Interaction Labs, Campo Grande 376, Lisboa 1749-024, Portugal.
| | - Sara Domínguez-Salas
- Departamento de Psicología Experimental, Universidad de Sevilla, Andalucia, Spain.
| | - Claire A Wilson
- Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust, United Kingdom.
| | - Ana Osorio
- Human Developmental Sciences Graduate Program & Mackenzie Center for Research in Childhood and Adolescence, Mackenzie Presbyterian University, São Paulo, Brazil.
| | - Eleni Vousoura
- Department of Psychology, School of Philosophy, National and Kapodistrian University of Athens, Greece.
| | - Ana Uka
- Department of Nursing and Physiotherapy, Western Balkans University, Albania.
| | | | - Yolanda Contreras-García
- Departamento de Obstetricia y Puericultura. Facultad de Medicina. Universidad de Concepción, Concepción. Chile.
| | | | - Andri Christoforou
- Department of Social and Behavioral Sciences, European University Cyprus, Nicosia, Cyprus.
| | - Emma Motrico
- Department of Developmental and Educational Psychology. Institute of Biomedicine of Seville (IBIS), University of Seville, Spain.
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Stewart S, Houghton SJ, Macqueen L. Addressing Cognitive Bias in Adolescents with Neurodevelopmental Disorders Using 3-D Animated Serious Games. Pediatr Rep 2025; 17:28. [PMID: 40126227 PMCID: PMC11932302 DOI: 10.3390/pediatric17020028] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/17/2024] [Revised: 02/14/2025] [Accepted: 02/20/2025] [Indexed: 03/25/2025] Open
Abstract
OBJECTIVE This study sought to evaluate the effectiveness of a serious game, that embeds cognitive bias modification for interpretation (CBM-I), in altering the negative interpretive bias of early aged adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Specific Learning Disorders. The difficulties that adolescents with neurodevelopmental disorders (NDDs) experience navigating the social nuances of everyday environments make them prone to the cognitive biases that lead to the development of negative thought patterns. Directly tackling the biased interpretive processes that give rise to negative thinking may be effective in reducing negative bias and mental health problems. METHOD Minds Online, a 10-episode 3-D animated serious game that embeds CBM-I was introduced using a three-phase multiple baseline design in a school setting. Eight adolescents diagnosed with an NDD completed the 10 episodes. RESULTS Real-time data revealed that seven of the eight adolescents altered their negative interpretive bias to a benign bias. However, pre- and post-test standardized measures revealed non-significant changes in the desired direction for mental health. Visual analyses of 308 daily self-reported ratings about worry about schoolwork, worry about peer relationships, and feelings of loneliness did not demonstrate a replicated intervention effect. However, when these interrupted time series data were analyzed statistically, significant individual improvements were evident. Engagement with Minds Online was excellent, as was adherence to daily data collection. CONCLUSIONS Minds Online seems to be highly effective in altering the negative interpretive biases of adolescents with NDDs, which is promising because such cognitive biases are involved in the onset and maintenance of psychopathology.
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Affiliation(s)
| | - Stephen John Houghton
- The Graduate School of Education, The University of Western Australia, Perth 6009, Australia; (S.S.); (L.M.)
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Sievertsen SA, Zhu J, Fang A, Forsyth JK. Resting-State Cortical Network and Subcortical Hyperconnectivity in Youth With Generalized Anxiety Disorder in the ABCD Study. BIOLOGICAL PSYCHIATRY. COGNITIVE NEUROSCIENCE AND NEUROIMAGING 2025:S2451-9022(25)00062-X. [PMID: 39988295 DOI: 10.1016/j.bpsc.2025.02.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Revised: 02/10/2025] [Accepted: 02/11/2025] [Indexed: 02/25/2025]
Abstract
BACKGROUND Generalized anxiety disorder (GAD) frequently emerges during childhood or adolescence, yet few studies have examined functional connectivity differences in youth with GAD. Functional magnetic resonance imaging (fMRI) studies of adults with GAD have implicated multiple brain regions; however, frequent examination of individual brain seed regions and/or networks has limited a holistic view of GAD-associated differences. The current study therefore used resting-state fMRI data from the Adolescent Brain Cognitive Development (ABCD) Study to investigate connectivity in youths with GAD across multiple cortical networks and subcortical regions implicated in adult GAD, considering diagnosis changes across 2 assessment periods. METHODS In 164 youths with GAD and 3158 healthy control participants, within- and between-network connectivity for 6 cortical networks and 6 subcortical regions was assessed using linear mixed-effect models. Changes in GAD-associated connectivity between baseline and 2-year follow-up were then compared for participants with continuous GAD, GAD at baseline and not follow-up (GAD remitters), and GAD at follow-up and not baseline (GAD converters) versus control participants. RESULTS Youths with GAD showed greater within-ventral attention network (VAN) connectivity and hyperconnectivity between the amygdala and cingulo-opercular network and between striatal regions and the cingulo-opercular, default mode, and salience networks (false discovery rate p < .05). Within-VAN connectivity decreased for GAD remitters between baseline and follow-up. Sensitivity analyses revealed that these hyperconnectivity patterns were not observed in youths with major depressive disorder (n = 19), separation anxiety (n = 33), or social anxiety disorder (n = 111) who did not have GAD. CONCLUSIONS Results indicate that GAD in childhood and adolescence is associated with altered subcortical to cortical network connectivity and that within-VAN hyperconnectivity, in particular, is associated with clinically significant GAD-specific symptoms.
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Affiliation(s)
- Sam A Sievertsen
- Department of Psychology, University of Washington, Seattle, Washington
| | - Jinhan Zhu
- Department of Psychology, University of Washington, Seattle, Washington
| | - Angela Fang
- Department of Psychology, University of Washington, Seattle, Washington
| | - Jennifer K Forsyth
- Department of Psychology, University of Washington, Seattle, Washington.
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Tomaszewski P, Krzysztofiak P, Kowalska J, Hauser PC. Internalized oppression and deaf people's mental health. Sci Rep 2025; 15:5268. [PMID: 39939356 PMCID: PMC11822193 DOI: 10.1038/s41598-025-89789-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/20/2024] [Accepted: 02/07/2025] [Indexed: 02/14/2025] Open
Abstract
Deaf people experience ableism (able-bodied oppression), audism (hearing-ability oppression), and linguicism (sign language-use oppression) and this study investigated if internalizing these oppressive experiences predicts their mental health. Deaf participants (N = 134) completed a 54-item Deaf Oppression Scale, developed for this study with Ableism, Audism, and Linguicism Subtests, along with the Beck Depression Inventory-II and the State and Trait Anxiety Inventory. The Deaf Oppression Scale and its Ableism, Audism, and Linguicism Subscales carry good reliability and the model fit indices for a confirmatory factor analysis indicated a good fit. Sixteen (16%) percent (n = 22) of the sample had depression, 36% (n = 48) had state anxiety, and 64% (n = 86) had trait anxiety. Internalized ableism predicted greater characteristics and symptoms of depression, internalized ableism and linguicism predicted greater state anxiety, and internalized audism predicted greater trait anxiety. This is the first empirical evidence dissociating three types of oppression that deaf people experience and their separate and different effects on their psychological well-being.
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Affiliation(s)
| | - Piotr Krzysztofiak
- Faculty of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland
| | | | - Peter C Hauser
- National Technical Institute for the Deaf Research Center on Culture and Language, Rochester Institute of Technology, Rochester, USA
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45
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Forsberg K, Sutton D, Stjernswärd S, Brown C, Bejerholm U, Argentzell E. Sensory processing patterns and their relationships to coping and occupational engagement in mental health service users. Aust Occup Ther J 2025; 72:e13016. [PMID: 39835693 PMCID: PMC11748359 DOI: 10.1111/1440-1630.13016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Revised: 10/22/2024] [Accepted: 01/02/2025] [Indexed: 01/22/2025]
Abstract
INTRODUCTION Mental health service users often have sensory processing difficulties hampering their ability to cope with mental health problems and occupational engagement. However, there is little knowledge of sensory processing and its relation to these factors. Hence, this current study aims to investigate sensory processing patterns in relation to coping and occupational engagement for the target group. METHODS This cross-sectional study involved 97 mental health service users. Sociodemographic information and self-rated questionnaires were administered; Adolescent/Adult Sensory Profile (AASP), Coping Orientation to Problems Experienced Inventory scale (short version) (Brief-COPE), and Profiles of Occupational Engagement among people with Severe mental illness (POES). Statistical analysis included descriptive statistics and multiple linear regression models. CONSUMER AND COMMUNITY INVOLVEMENT This study sits within an RCT project where parts were designed collaboratively with research-educated service users. RESULTS The result showed strong relationships between sensory processing patterns and occupational engagement. Low levels of occupational engagement were related to high levels of sensory sensitivity, sensation avoiding, and low registration. Whereas, high levels of occupational engagement were related to high levels of sensation-seeking. Concerning coping styles, high levels of emotion-focused coping were related to high levels of low registration, while high levels of avoidant coping styles were related to high levels of sensation-seeking. CONCLUSION The findings indicate that occupational engagement and coping styles are related to outcomes of the sensory profile and thus affect how a person with severe mental health problems interprets and reacts to sensory stimuli in daily life.
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Affiliation(s)
- Klara Forsberg
- Department of Health Sciences, Mental Health, Activity and Participation (MAP)Lund UniversityLundSweden
- Department of PsychiatryHabilitation and Aids, Region SkåneLundSweden
| | - Daniel Sutton
- School of Clinical SciencesAuckland University of TechnologyAucklandNew Zealand
| | - Sigrid Stjernswärd
- Department of Health Sciences, Mental Health, Activity and Participation (MAP)Lund UniversityLundSweden
| | - Catana Brown
- Department of Occupational TherapyMidwestern University GlendaleGlendaleCaliforniaUSA
| | - Ulrika Bejerholm
- Department of Health Sciences, Mental Health, Activity and Participation (MAP)Lund UniversityLundSweden
- Department of PsychiatryHabilitation and Aids, Region SkåneLundSweden
| | - Elisabeth Argentzell
- Department of Health Sciences, Mental Health, Activity and Participation (MAP)Lund UniversityLundSweden
- Department of PsychiatryHabilitation and Aids, Region SkåneLundSweden
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46
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Mandalaywala TM, Coyne SP. Threat perception and behavioral reactivity in response to an acute stressor in infant rhesus macaques. Acta Psychol (Amst) 2025; 252:104647. [PMID: 39662358 PMCID: PMC11855842 DOI: 10.1016/j.actpsy.2024.104647] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2024] [Revised: 12/02/2024] [Accepted: 12/05/2024] [Indexed: 12/13/2024] Open
Abstract
Attentional bias to threat is an adaptive response to the presence of threat and danger in the environment (Haselton et al., 2009; Pollak, 2008). Attentional bias to threat is present in both human and nonhuman primates (e.g., Mandalaywala, Parker, & Maestripieri, 2014) and attentional bias to threat is exacerbated during periods of acute stress in rhesus macaque adults (Bethell et al., 2012a,b). Here, we build on this extant work to assess whether 5-month-old infant rhesus macaques, previously believed to be too young to express attentional bias to threat, might actually demonstrate attentional bias in response to an acute stressor. At approximately 5 months of age, free-ranging rhesus macaque infants on Cayo Santiago, Puerto Rico (N = 44) were briefly separated from their social group and underwent a maternal separation test, a validated stressor shown to induce anxiety in infant monkeys (Sánchez et al., 2001). We assessed their behavioral (Temperament Task) and cognitive (Threat perception/Vigilance for Threat task) reactivity. Across these two reactivity tests, infants could be classified as "vigilant-fighters"-trying to escape and paying more attention to a threatening than a neutral stimulus-or as "avoidant-freezers"-staying still and quiet and avoiding looking at the threatening stimulus in favor of the neutral stimulus. This behavioral and cognitive phenotype was related to infants' early life experiences, including exposure to early life adversity, and suggests both that attention to threat can be present as young as 5 months of age, and that infants quickly learn behavioral and cognitive strategies for coping with their particular circumstances.
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Affiliation(s)
- Tara M Mandalaywala
- Department of Comparative Human Development, The University of Chicago, Chicago, IL, USA; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
| | - Sean P Coyne
- Department of Comparative Human Development, The University of Chicago, Chicago, IL, USA; Department of Psychology, Washington & Jefferson College, Washington, PA, USA.
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47
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Lee SH, Chou TL. Insular-striatal activation during COVID-19 predicts stress reactivity in high-trait anxiety. Biol Psychol 2025; 195:108998. [PMID: 39952428 DOI: 10.1016/j.biopsycho.2025.108998] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/11/2024] [Revised: 01/09/2025] [Accepted: 02/02/2025] [Indexed: 02/17/2025]
Abstract
The COVID-19 pandemic, unlike natural disasters that cause short-term stress, has led to prolonged psychological strain, increasing attentional biases toward health threats and worsening mental health. Prolonged exposure to pandemic-related stressors has exacerbated these issues, with individual differences, such as anxiety levels, influencing vulnerability and resulting in varied outcomes. Understanding how neurocognitive processes modulate attentional biases, such as prolonged attention (overresponding) to threats or avoidance, is crucial for explaining their effects on mental health during the pandemic. Real-world examination of these biases is needed to confirm their manifestation and better target interventions. This longitudinal study explored the neural network of attentional biases in anxious individuals, focusing on whether initial activation at baseline (T1) could predict changes in perceived stress. High and low trait anxious (HTA, LTA) adults completed an emotional Stroop task during two fMRI visits, one year apart. Results showed insular-fronto-striatal hypoactivation in the HTA group over time, indicating increased avoidance in HTA participants. Initial insular-striatal activation at T1 predicted perceived stress changes in the HTA group. Reduced activation in these regions suggests avoidance and impaired stress coping, highlighting increased stress vulnerability in HTA individuals during the pandemic and underscoring the importance of interventions to enhance resilience.
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Affiliation(s)
- Shu-Hui Lee
- Center for General Education, National Tsing Hua University, Taiwan.
| | - Tai-Li Chou
- Department of Psychology, National Taiwan University, Taiwan; Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taiwan; Neurobiology and Cognitive Science Center, National Taiwan University, Taiwan.
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48
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Kappel S, Collins S, Mendl M, Fureix C. Looking out for danger: Theoretical and empirical issues in translating human attention bias tasks to assess animal affective states. Neurosci Biobehav Rev 2025; 169:105980. [PMID: 39667693 DOI: 10.1016/j.neubiorev.2024.105980] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2024] [Revised: 11/23/2024] [Accepted: 12/09/2024] [Indexed: 12/14/2024]
Abstract
Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention in humans, before concentrating on the relationship between AB to threat detection and human anxiety. We critically review animal AB studies, discuss methodological discrepancies in such studies, and highlight the need for further experimental refinements. This includes identifying appropriate species-specific test designs and stimuli, modes of presentation (e.g., real-life vs. artificial stimuli), and consideration of subject-related factors (e.g., personality, age). We conclude that experimental limitations currently hamper the validity of AB as a proxy of animal affect and hope that the knowledge gaps highlighted in our review will encourage further research.
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Affiliation(s)
- Sarah Kappel
- University of Plymouth, School of Biological and Marine Sciences, Portland Square, Drake Circus, Plymouth PL4 8AA, UK.
| | - Sarah Collins
- University of Plymouth, School of Biological and Marine Sciences, Portland Square, Drake Circus, Plymouth PL4 8AA, UK
| | - Michael Mendl
- University of Bristol, Bristol Veterinary School, Langford House, Langford BS40 5DU, UK
| | - Carole Fureix
- University of Plymouth, School of Biological and Marine Sciences, Portland Square, Drake Circus, Plymouth PL4 8AA, UK; University of Bristol, Bristol Veterinary School, Langford House, Langford BS40 5DU, UK
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49
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Baroncelli A, Righi S, Facci C, Ciucci E. Behavioral Inhibition and Fear: The Moderating Role of Emotional Competence and Gender in Preadolescents. CHILDREN (BASEL, SWITZERLAND) 2025; 12:179. [PMID: 40003281 PMCID: PMC11854494 DOI: 10.3390/children12020179] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/30/2024] [Revised: 01/23/2025] [Accepted: 01/29/2025] [Indexed: 02/27/2025]
Abstract
BACKGROUND The behavioral inhibition system (BIS) is a key motivational system that shapes human emotions and behaviors; specifically, the BIS regulates avoidance behaviors, and it is linked to negative emotions such as fear and anxiety. Previous studies have demonstrated a link between high BIS scores and attentional bias to threat in children, but literature is inconsistent. This may be due to differences in the individual awareness of emotions or in the accuracy of effectively detecting emotions. Moreover, the past literature has also found gender differences in BIS scores, which may suggest differential processes in boys and girls. METHODS The present study aims to investigate whether BIS scores were associated with an attentional facilitation index of fear in a sample of preadolescents (n = 264; 52.27% girls; M age = 12.98 years; SD = 0.89 years), considering the potential moderating role of (a) the awareness of others' emotions as assessed by a self-report questionnaire, (b) emotion perception accuracy of fear as assessed by a laboratory task of emotion recognition, and (c) gender. RESULTS Our results showed that, only in males, higher scores of the BIS were associated with a lower attentional facilitation index of fear in the conditions of low levels of emotional competence (i.e., low levels of self-reported awareness of other emotions or low levels of accuracy recognition of fearful faces). CONCLUSIONS Results were discussed in light of both theories of emotional development and practical clinical implications, with special attention to the emerged gender difference.
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Affiliation(s)
- Andrea Baroncelli
- Department of Philosophy, Social Sciences and Education, University of Perugia, 06123 Perugia, Italy;
| | - Stefania Righi
- Department of Neuroscience, Psychology, Drug Research and Child’s Health, University of Florence, 50139 Florence, Italy;
| | - Carolina Facci
- Department of Education, Languages, Interculture, Literatures and Psychology, University of Florence, 50135 Florence, Italy;
| | - Enrica Ciucci
- Department of Education, Languages, Interculture, Literatures and Psychology, University of Florence, 50135 Florence, Italy;
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50
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Jessup SC, Armstrong T, Rast CE, Woronko SE, Jackson M, Anwyl-Irvine AL, Dalmaijer ES, Olatunji BO. Benefits of the "worst-case scenario": a multi-level examination of the effects of confronting the feared outcome during imagery-based exposure. Cogn Behav Ther 2025:1-20. [PMID: 39882772 DOI: 10.1080/16506073.2025.2456479] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/28/2024] [Accepted: 01/13/2025] [Indexed: 01/31/2025]
Abstract
Exposure therapy is an efficacious treatment for anxiety-related disorders. Yet, fear often returns after treatment. Occasional reinforcement, in which the feared stimulus is intermittently presented during extinction, increases safety learning and slows fear renewal in conditioning paradigms and analogue samples, but no studies to date have examined this strategy in clinical samples. The present study examined the effects of vicarious occasional reinforcement on fear renewal in a snake-phobic sample across multiple levels of analysis. Fear was intermittently reinforced by providing reminders of the feared outcome (a snake bite) throughout a two-session analogue video exposure manipulation. Snake-phobic adults were randomized to one of three conditions: a single-cue [S], multiple-cue [M], or multiple-cue+fear-outcome [M+FO] exposure group. Results showed the three groups did not significantly differ in threat expectancy or attentional bias for threat at follow-up. Despite sustained anxiety, however, the M+FO condition completed significantly more steps on a visual avoidance task at follow-up than the M and S conditions and heightened mean distress during exposure mediated this effect. The M and S groups did not significantly differ in visual avoidance at follow-up. These findings suggest incorporating reminders of the feared outcome into exposure may be an effective strategy for increasing inhibitory retrieval.
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Affiliation(s)
- Sarah C Jessup
- Department of Psychology, Vanderbilt University, 312 Wilson Hall, 111 21st Avenue South, Nashville, TN 37240, USA
| | - Thomas Armstrong
- Psychology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA
| | - Catherine E Rast
- Psychology, Baylor College of Medicine, 1 Baylor Plz, Houston, TX 77030, USA
| | - Sarah E Woronko
- Psychology, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
| | - Mitchell Jackson
- Psychology, Brown University, 190 Thayer St, Providence, RI 02912, USA
| | | | - Edwin S Dalmaijer
- Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK
| | - Bunmi O Olatunji
- Department of Psychology, Vanderbilt University, 312 Wilson Hall, 111 21st Avenue South, Nashville, TN 37240, USA
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