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Ghobadi A, Jamali S. Identification of Fungal Species Associated with Gall Oak ( Quercus infectoria) Decline in Iran. PLANT DISEASE 2025; 109:96-106. [PMID: 39320377 DOI: 10.1094/pdis-05-24-0974-re] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/26/2024]
Abstract
The gall oak (Quercus infectoria Oliv.) tree is one of the most important and valuable forestry species in the Northern Zagros forests in the west of Iran. Gall oak decline is considered to be one of the most important diseases currently affecting the Zagros oak forests in Iran. The main objective of the present study, conducted in the years 2021 to 2023, was to investigate the possible role of fungi as causative agents of gall oak dieback in the Zagros forests of Iran. Wood samples were taken from gall oak trees showing canker, dieback, and internal wood discoloration symptoms. Fungal isolates recovered from gall oak trees were identified based on cultural and morphological characteristics, as well as phylogenetic analyses using DNA sequencing of the internal transcribed spacer region of rDNA and partial beta-tubulin. Achaetomium aegilopis, Alternaria tenuissima, Apiospora intestini, Botrytis cinerea, Coniochaeta sp., Coniothyrium palmarum, Coniothyrium sp., Cytospora rhodophila, Dialonectria episphaeria, Diatrype sp., Diatrypella macrospora, Endoconidioma populi, Fonsecazyma sp., Fusarium ipomoeae, Jattaea discreta, Kalmusia variispora, Microsphaeropsis olivacea, Neoscytalidium dimidiatum, Paecilomyces lecythidis, Paramicrosphaeropsis eriobotryae, Paramicrosphaeropsis ellipsoidea, and Seimatosporium pezizoides were identified from diseased trees. Pathogenicity tests were performed by artificial inoculation of excised branches of healthy gall oak trees under controlled conditions and evaluated after 35 days by measuring the discolored lesion length at the inoculation site. N. dimidiatum was the most virulent species and caused the longest wood necrosis within 35 days of inoculation. In the greenhouse test, only some species induced typical symptoms of canker. All isolated fungi are reported for the first time on gall oak trees in the world.
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Affiliation(s)
- Armin Ghobadi
- Department of Plant Protection, College of Agriculture, Razi University, Kermanshah, Iran
| | - Samad Jamali
- Department of Plant Protection, College of Agriculture, Razi University, Kermanshah, Iran
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Alobaidi S. Renal health benefits and therapeutic effects of parsley ( Petroselinum crispum): a review. Front Med (Lausanne) 2024; 11:1494740. [PMID: 39735703 PMCID: PMC11672790 DOI: 10.3389/fmed.2024.1494740] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2024] [Accepted: 11/29/2024] [Indexed: 12/31/2024] Open
Abstract
Parsley (Petroselinum crispum) has been used in traditional medicine for its diverse health benefits, and recent research highlights its potential in promoting renal health due to its bioactive compounds. This review focuses on evaluating the renal health benefits and therapeutic effects of parsley, addressing the growing interest in natural interventions for kidney-related conditions. It aims to consolidate existing evidence while identifying research gaps to support parsley's integration into renal health management. A systematic review of scientific databases was conducted, identifying relevant studies on parsley's biochemical properties, including flavonoids, phenolic acids, terpenoids, and essential oils, which contribute to antioxidant, anti-inflammatory, diuretic, and nephroprotective effects. Animal studies demonstrated reductions in oxidative stress, improvements in metabolic biomarkers, and enhanced renal function, while limited human studies revealed modest improvements in urinary composition and renal health markers. However, parsley's safety profile, particularly at high doses, requires further investigation, including potential herb-drug interactions and safety during pregnancy. This review highlights parsley's therapeutic potential as a natural agent for renal health and underscores the need for robust clinical trials, long-term safety evaluations, and standardized methodologies to validate its clinical significance.
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Bai J, Ding Y, Iminjan M, Kuerban K. Thermosensitive and pH-responsive quercus infectoria gall-containing gel with long-lasting anti-inflammatory activity for ulcerative colitis. Heliyon 2024; 10:e36225. [PMID: 39435110 PMCID: PMC11492468 DOI: 10.1016/j.heliyon.2024.e36225] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/10/2024] [Revised: 08/11/2024] [Accepted: 08/12/2024] [Indexed: 10/23/2024] Open
Abstract
In the study, quercus infectoria gall (QIG) was used to develop a pH/thermosensitive gel in situ delivery system for enema administration of to treat acute ulcerative colitis (UC). The QIG ethanol extract pH/temperature-sensitive gel (QIG-pH-TSG) was characterized by using DSC, SEM, rheological and drug release analyses. The therapeutic effect in UC mice of the obtained gel were studied. The gel was maintained in a flowing liquid state under nonphysiological conditions (25 °C) to facilitate drug administration, and was transformed into a pseudoplastic liquid state under physiological conditions (37 °C), which prolonged its retention time in the colon. The gel drug was completely released within 24 h, and the temperature and viscosity of the gel were within the required range. In the in vitro anti-inflammatory test, QIG-pH-TSG decreased the level of TNF-α and IL-6, and increased IL-10 in RAW 264.7 actived by LPS. Moreover, the administration of QIG-pH-TSG resulted in a decrease in the colon histopathological score and an increase in colonic length, and also could reduce the IL-6, TNF-α, and C-reactive protein (CRP) levels in UC mice along with significant increases in IL-10 level in the colon. The QIG-pH-TSG could increase the concentration of QIG at the local inflammatory site and lead to an effective repair of the colonic mucosa. Therefore, the pH/thermosensitive in situ gel may serve as a drug delivery system for QIG to treat UC and overcome the limitations of some existing formulations. These results indicated that this composite gel was effectively in UC mice and the study provided a practical reference for the application of QIG-pH-TSG in the treatment of UC.
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Affiliation(s)
- Jiaojiao Bai
- College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China
| | - Yan Ding
- College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China
| | - Mubarak Iminjan
- College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China
- The Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China
| | - Kudelaidi Kuerban
- College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China
- The Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China
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Wunnoo S, Sermwittayawong D, Praparatana R, Voravuthikunchai SP, Jakkawanpitak C. Quercus infectoria Gall Ethanolic Extract Accelerates Wound Healing through Attenuating Inflammation and Oxidative Injuries in Skin Fibroblasts. Antioxidants (Basel) 2024; 13:1094. [PMID: 39334753 PMCID: PMC11428264 DOI: 10.3390/antiox13091094] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Revised: 08/23/2024] [Accepted: 09/03/2024] [Indexed: 09/30/2024] Open
Abstract
Quercus infectoria Olivier (Fagaceae) nutgall, a traditional Asian medicine, is renowned for its efficacy in treating wounds and skin disorders. Although the gall extract has shown promising results in accelerating wound healing in diabetic animal models, its mechanisms, particularly the effects on redox balance, remain poorly understood. This study aims to investigate the effects and mechanisms of Q. infectoria gall ethanolic extract (QIG) on wound healing in fibroblasts, with a specific emphasis on its modulation of oxidative stress. Hydrogen peroxide (H2O2)-treated L929 cells were used as an in vitro model of oxidation-damaged fibroblasts. QIG exhibited potent antioxidant activity with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) assay values of 305.43 ± 7.48, 508.94 ± 15.12, and 442.08 ± 9.41 µM Trolox equivalents (TE)/µg, respectively. Elevated H2O2 levels significantly reduced L929 cell viability, with a 50% lethal concentration of 1.03 mM. QIG mitigated H2O2-induced cytotoxicity in a dose-dependent manner, showing protective effects in pre-, post-, and co-treatment scenarios. QIG significantly reduced H2O2-induced intracellular reactive oxygen species production and inflammation-related gene expression (p < 0.05). Additionally, at 25 µg/mL, QIG remarkably improved wound closure in H2O2-treated L929 cells by approximately 9.4 times compared with the H2O2 treatment alone (p < 0.05). These findings suggest QIG has potential therapeutic applications in wound healing, mediated through the regulation of oxidative stress and inflammatory response.
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Affiliation(s)
- Suttiwan Wunnoo
- Center of Antimicrobial Biomaterial Innovation-Southeast Asia, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand; (S.W.); (S.P.V.)
| | - Decha Sermwittayawong
- Center of Excellence for Biochemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand;
- Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
| | - Rachanida Praparatana
- Faculty of Medical Technology, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand;
| | - Supayang Piyawan Voravuthikunchai
- Center of Antimicrobial Biomaterial Innovation-Southeast Asia, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand; (S.W.); (S.P.V.)
| | - Chanawee Jakkawanpitak
- Center of Excellence for Biochemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand;
- Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
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Fahim MFM, Zarnigar P. Effect of prepared herbal mouthwash in maintaining the oral health of school children: A single-blind randomised control trial. Explore (NY) 2024; 20:535-543. [PMID: 38594113 DOI: 10.1016/j.explore.2023.12.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2023] [Revised: 12/06/2023] [Accepted: 12/12/2023] [Indexed: 04/11/2024]
Abstract
BACKGROUND AND AIM Oral health is a vital indicator of overall well-being, quality of life, and general health, with historical roots in Unani medicine (i.e. preventive measures, oral hygiene, and treatment). This study aims to assess the efficacy and safety of prepared herbal mouthwash in maintaining oral health among school children. EXPERIMENTAL PROCEDURE 110 schoolchildren were randomly assigned to the test group (treated with herbal mouthwash -Anacyclus pyrenthrum DC, Punica granutum (pericarp), Capparis spinosa (root bark), and Quercus infectoria Oliv (galls)) and the control group (treated with 0.2 % Chlorhexidine Mouthwash) for 30-days. The response was assessed by DMFT, Salivary pH, Oral hygiene index-simplified (OHI-S), Plaque index (Loe & Silness) (PI), Plaque index simplified (O'Leary et al., 1972) (PI-S), Gingival Index (Löe-Silness) (GI), and Bleeding on probing (BOP) on baseline and 30th day GI and PI were further assessed on 60th, 90th and 120th days to determine the sustainable effect of the intervention. RESULTS After treatment, Mean OHI-S, PI, PI-S, GI and BOP significantly reduced on the 30th day from baseline (p ≤ 0.001) in both groups. After discontinuing intervention, both groups showed significantly lower PI and GI scores on the 120th day from baseline. (p < 0.001). CONCLUSION This study revealed that prepared mouthwash is safe and significantly effective in maintaining oral health, and it could be used as an adjunct to mechanical oral hygiene measures.
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Affiliation(s)
- M F M Fahim
- Department of Tahaffuzi wa Samaji Tibb (Preventive and Social Medicine), National Institute of Unani Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India.
| | - Prof Zarnigar
- Department of Tahaffuzi wa Samaji Tibb (Preventive and Social Medicine), National Institute of Unani Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India
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Agrawal J, Pant AB, Agrawal RK. Comparative assessment of medicinal plant extract efficacy against plaque and gingivitis: A case-control study. J Indian Soc Periodontol 2024; 28:204-209. [PMID: 39411729 PMCID: PMC11472968 DOI: 10.4103/jisp.jisp_396_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/31/2023] [Revised: 06/10/2024] [Accepted: 07/04/2024] [Indexed: 10/19/2024] Open
Abstract
Background In the last quarter of the 20th century, dedicated efforts have been made to use phytochemicals in the prevention of periodontal diseases, but the darker side of the coin is that we have hardly encountered studies with a scientific basis to prove the specific role of phytochemicals against dental plaque. Objective This study aimed to assess the antiplaque activity of Curcuma longa, Spilanthes acmella, and Quercus infectoria and to determine the antigingivitis activity of the extract, which shows high antiplaque potential. Materials and Methods Sixteen volunteers were selected as subjects in this biphasic study. In the first phase, 10 volunteers were subjected to topical application of aqueous ethanolic extract (1%) of C. longa, Q. infectoria, and S. acmella on the labial/buccal and lingual/palatal surfaces of 28 teeth. In the second phase, the extract showing the highest efficacy was selected to assess its antigingivitis activity on all the surfaces of six mandibular anterior teeth of six gingivitis patients. The percentage plaque reduction was calculated by dividing the difference of the base and end scores by the baseline scores. Results C. longa demonstrated superior results as it showed the maximum reduction in plaque formation. Antigingivitis activity of long-term topical application of 1% C. longa was depicted in independent clusters in different volunteers selected for the study. Only after 2 weeks, the treatment score was found to be statistically significant to depict optimal results. Conclusion C. longa can be considered the best at reducing plaque. The antigingivitis activity of C. longa ranked reasonably satisfactory and comparable to the existing data for commercially available drugs.
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Affiliation(s)
- Jyoti Agrawal
- Department of Dentistry, Autonomous State Medical College, Sonebhadra, India
| | - Aditya Bhusan Pant
- System Toxicology Department, CSIR-Indian Institute of Toxicology Research, Lucknow, India
| | - Rajesh Kumar Agrawal
- Department of Dentistry, Government Medical College and Super Facility Hospital, Azamgarh, Uttar Pradesh, India
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Choudhry A, Akhtar N. Formulation, characterization of Quercus infectoria (Olivier) emulsions, and in vitro, in vivo evaluation as cosmeceutical formulation. J Cosmet Dermatol 2023; 22:3480-3490. [PMID: 37335816 DOI: 10.1111/jocd.15865] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2023] [Revised: 05/14/2023] [Accepted: 05/30/2023] [Indexed: 06/21/2023]
Abstract
BACKGROUND Pharmacological properties of Quercus infectoria Olivier (galls) have been determined to be astringent, antidiabetic, antipyretic, anti-tremor, local anesthetic, and anti-parkinsonism. The galls of Quercus infectoria have been used for millennia in traditional oriental medicine in Asian nations to treat inflammatory illnesses. AIMS The study's objective was to create a Quercus infectoria Olivier gall extract in stable water in oil (w/o) emulsion and to check its effects on the mechanical properties of skin and antiaging effects. METHOD The galls were macerated in absolute methanol. Quercus infectoria Olivier gall extract's antioxidant property was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) technique. Stearic acid, cetyl alcohol, KOH, glycerin, and distilled water were used to create the emulsion. The test (with extract) and control (without extract) emulsions were made, respectively, using the same process. Stability tests (color, liquefaction, microscopy, phase separation, and pH) are performed in in vitro, lasted 72 days at four distinct storage temperatures that is 8°C, 25°C, 40°C, and 40°C + 75% RH for both the control and test formulations. By using spectrophotometry, the (SPF) sun protection factors of the two formulations were calculated at various concentrations. Extract from Quercus infectoria underwent phytochemical investigation as well. RESULTS The results showed that Quercus infectoria Olivier has antioxidant and (SPF) sun protection properties, reduce sebum, increases elasticity and stable emulsion containing 04% Quercus infectoria gall extract which might be used as topical antiaging formulation.
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Affiliation(s)
- Ammara Choudhry
- Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
| | - Naveed Akhtar
- Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
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Banc R, Rusu ME, Filip L, Popa DS. Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years. PLANTS (BASEL, SWITZERLAND) 2023; 12:3873. [PMID: 38005770 PMCID: PMC10674842 DOI: 10.3390/plants12223873] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/08/2023] [Revised: 11/12/2023] [Accepted: 11/14/2023] [Indexed: 11/26/2023]
Abstract
Quercus species have been widely used in traditional medicine, and recently, researchers' attention has focused on galls of the genus Quercus as a source of health-promoting phytochemicals. This review presents a summary of the most recent findings on the phytochemistry and bioactivity of oak galls, following the screening of scientific papers published in two relevant databases, PubMed and Embase, between January 2018 and June 2023. The oak galls are rich in active compounds, mostly gallotannins and phenolic acids. Due to these secondary metabolites, the reviewed studies have demonstrated a wide range of biological activities, including antioxidant and anti-inflammatory actions, antimicrobial properties, tissue-protective effects, and antitumor, anti-aging, and hypoglycemic potential. Thus, oak galls are a promising natural matrix, to be considered in obtaining pharmaceutical and cosmetic preparations used in anti-aging strategies and, together with medications, in the management of age-related diseases. In further evaluations, the valuable functional properties of oak galls, reported mostly in preclinical studies, should be confirmed with clinical studies that would also take into account the potential health risks of their use.
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Affiliation(s)
- Roxana Banc
- Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania; (R.B.); (L.F.)
| | - Marius Emil Rusu
- Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 12 Ion Creangǎ Street, 400010 Cluj-Napoca, Romania
| | - Lorena Filip
- Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania; (R.B.); (L.F.)
| | - Daniela-Saveta Popa
- Department of Toxicology, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania;
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Saini AK, Zahiruddin S, Newton KG, Sawant L, Mitra R, Kumar Rai R, Ahmad S. Validation and Standardization of Gallic Acid and Ellagic Acid in Quercus Infectoria, Terminalia Chebula, and Pistacia Integerrima. J AOAC Int 2023; 106:1305-1312. [PMID: 37294736 DOI: 10.1093/jaoacint/qsad070] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/01/2023] [Revised: 05/21/2023] [Accepted: 05/25/2023] [Indexed: 06/11/2023]
Abstract
BACKGROUND Due to its medicinal properties, Pistacia integerrima is in high demand and is extensively used as a key ingredient in various formulations. However, its popularity has led to its inclusion on the International Union for Conservation of Nature threatened category list. In Ayurvedic texts, such as Bhaishajaya Ratnavali, Quercus infectoria is recommended as a substitute for P. integerrima in different formulations. Additionally, Yogratnakar highlights that Terminalia chebula shares similar therapeutic properties with P. integerrima. OBJECTIVE The objective of the current study was to gather scientific data on metabolite profiling and marker-based comparative analysis of Q. infectoria, T. chebula, and P. integerrima. METHODS In present study, hydroalcoholic and aqueous extracts of all three plants were prepared and standardized for the comparative evaluation of secondary metabolites. TLC was carried out for the comparative fingerprinting of the extracts using chloroform-methanol-glacial acetic acid-water (60 + 8 + 32 + 10, by volume) as a solvent system. A fast, sensitive, selective, and robust HPLC method was developed to determine gallic acid and ellagic acid from both extracts of all three plants. The method was validated for precision, robustness, accuracy, LOD and LOQ as per the International Conference on Harmonization guidelines. RESULTS The TLC analysis revealed the presence of several metabolites, and the pattern of metabolites in the plants exhibited a certain degree of similarity. A highly precise and reliable quantification technique was created for gallic acid and ellagic acid, operating within a linear concentration range of 81.18-288.22 µg/mL and 3.83-13.66 µg/mL, respectively. The correlation coefficients for gallic acid and ellagic acid were 0.997 and 0.996, indicating good linear relationships. The gallic acid content in all three plants ranged from 3.74 to 10.16% w/w, while the ellagic acid content ranged from 0.10 to 1.24% w/w. CONCLUSION The study contributes to the scientific understanding of the metabolite profiles and comparative analysis of Q. infectoria, T. chebula, and P. integerrima. The findings provide valuable insights into the chemical composition of these plants and can be used for various applications in herbal medicine. HIGHLIGHTS This pioneering scientific approach highlights the phytochemical similarities between Q. infectoria, T. chebula and P. integerrima.
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Affiliation(s)
- Anil Kumar Saini
- Jamia Hamdard, Centre of Excellence in Unani Medicine (Pharmacognosy & Pharmacology), & Bioactive Natural Product Laboratory, School of Pharmaceutical Education & Research, New Delhi 110062, India
- Dabur India Limited,Dabur Research and Development Centre, Plot No. 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
| | - Sultan Zahiruddin
- Jamia Hamdard, Centre of Excellence in Unani Medicine (Pharmacognosy & Pharmacology), & Bioactive Natural Product Laboratory, School of Pharmaceutical Education & Research, New Delhi 110062, India
| | - Kakumani Godwin Newton
- Dabur India Limited,Dabur Research and Development Centre, Plot No. 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
| | - Laxman Sawant
- Dabur India Limited,Dabur Research and Development Centre, Plot No. 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
| | - Ranjan Mitra
- Dabur India Limited,Dabur Research and Development Centre, Plot No. 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
| | - Rajiva Kumar Rai
- Dabur India Limited,Dabur Research and Development Centre, Plot No. 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
| | - Sayeed Ahmad
- Jamia Hamdard, Centre of Excellence in Unani Medicine (Pharmacognosy & Pharmacology), & Bioactive Natural Product Laboratory, School of Pharmaceutical Education & Research, New Delhi 110062, India
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Narzary I, Swarnakar A, Kalita M, Middha SK, Usha T, Babu D, Mochahary B, Brahma S, Basumatary J, Goyal AK. Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21 st century: A systematic review. World J Clin Cases 2023; 11:4035-4059. [PMID: 37388781 PMCID: PMC10303622 DOI: 10.12998/wjcc.v11.i17.4035] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/06/2023] [Revised: 04/24/2023] [Accepted: 05/16/2023] [Indexed: 06/12/2023] Open
Abstract
BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on "the plants for the treatment of DFU" studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis), omega-3-fatty acid (in Linum usitatissimum), isoquercetin (in Melilotus officinalis), anthocyanins (in Myrtus communis), and plantamajoside (in Plantago major). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.
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Affiliation(s)
- Illora Narzary
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
- Department of Zoology, Baosi Banikanta Kakati College, Barpeta 781311, Assam, India
| | - Amit Swarnakar
- Medical Unit, Bodoland University, Kokrajhar 783370, Assam, India
| | - Mrinal Kalita
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
| | - Sushil Kumar Middha
- Department of Biotechnology, Maharani Lakshmi Ammanni College for Women, Bengaluru 560012, Karnataka, India
| | - Talambedu Usha
- Department of Biochemistry, Maharani Lakshmi Ammanni College for Women, Bengaluru 560012, Karnataka, India
| | - Dinesh Babu
- Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
| | - Banjai Mochahary
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
| | - Sudem Brahma
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
| | - Jangila Basumatary
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
| | - Arvind Kumar Goyal
- Department of Biotechnology, Bodoland University, Kokrajhar 783370, Assam, India
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Joudaki F, Ismaili A, Sohrabi SS, Hosseini SZ, Kahrizi D, Ahmadi H. Transcriptome analysis of gall oak (Quercus infectoria): De novo assembly, functional annotation and metabolic pathways analysis. Genomics 2023; 115:110588. [PMID: 36841311 DOI: 10.1016/j.ygeno.2023.110588] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2022] [Revised: 02/16/2023] [Accepted: 02/21/2023] [Indexed: 02/27/2023]
Abstract
Gall oak (Quercus infectoria) is a native tree of Iran, whose gall extract is used to treat many diseases. The presence of abundant secondary metabolites with various bioactivities in this plant has made it medically important. Despite its medicinal value, due to the lack of genomic information, the biosynthetic pathways of these compounds in this species are still unknown. The current research was aimed at observing, characterizing, and investigating the biosynthetic pathways of these compounds in Q.infectoria. De novo transcriptome assembly was conducted using the RNA sequencing technique. A total of 89,335 unigenes were generated, of which 6928 unigenes showed differential expression in leaves compared to root tissue. Gene ontology examination of DEGs revealed GO-term enrichment was related to cellular processes and enzyme activity. KEGG enrichment analysis for DEGs showed that most unigenes were related to metabolic pathways and biosynthesis of secondary metabolites. Moreover, 39 families of transcription factors were identified, of which the C2H2, bZIP, bHLH, and ERF TFs had the highest frequency. In the absence of a reference genome, the overall study of transcriptome will provide a reference for future functional and comparative studies. Moreover, the data obtained from sequencing and de novo assembly can be a valuable scientific resource for Q.infectoria.
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Affiliation(s)
- Forough Joudaki
- Department of Plant Production and Genetic Engineering, Faculty of Agriculture, Lorestan University, Khorramabad, Iran
| | - Ahmad Ismaili
- Department of Plant Production and Genetic Engineering, Faculty of Agriculture, Lorestan University, Khorramabad, Iran.
| | - Seyed Sajad Sohrabi
- Department of Plant Production and Genetic Engineering, Faculty of Agriculture, Lorestan University, Khorramabad, Iran.
| | - Seyedeh Zahra Hosseini
- Department of Plant Production and Genetic Engineering, Faculty of Agriculture, Lorestan University, Khorramabad, Iran.
| | - Danial Kahrizi
- Agricultural Biotechnology Department, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
| | - Hadi Ahmadi
- Department of Plant Production and Genetic Engineering, Faculty of Agriculture, Lorestan University, Khorramabad, Iran.
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12
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Saini AK, Sawant L, Zahiruddin S, Shrivastva D, Mitra R, Rai RK, Ahmad S. LC-MS/MS-based Targeted Metabolomic Profiling of Aqueous and Hydro-alcoholic Extracts of Pistacia integerrima Linn., Quercus infectoria Olivier and Terminalia chebula Retz. Pharmacogn Mag 2023. [DOI: 10.1177/09731296221144809] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/11/2023] Open
Abstract
Background Pistacia integerrima (PI) galls, being rich in polyphenolic compounds, owing to its high restorative worth and restricted assets and exorbitant utilization lead to the overexploitation of the species and availability issues. It is expected to categorise under the red list of threatened taxa. Ayurveda text Bhaishajaya Ratnavali mentioned Quercus infectoria (QI) as ‘pratinidhi’ or substitute of PI and Yogaratnakara (abhavvarga) text reference indicated Terminalia chebula (TC) having the same therapeutic character as in PI. Hence, this study was focused on the comparative quantification of major polyphenolic compounds in aqueous and hydro-alcoholic extracts of PI, QI and TC by liquid chromatography and tandem mass spectroscopy (LC-MS/MS). Objectives The LC-MS/MS method was used for the determination of polyphenolic compounds in aqueous and hydro-alcoholic extracts of PI, QI and TC. Materials and Methods The LC-MS/MS method was developed for the quantification of targeted polyphenolic compounds and validated in terms of linearity, accuracy, precision, limit of detection and limit of quantification. Analysis performed by LC-MS/MS 6460 C triple quad coupled with Agilent HPLC. The chromatographic separation was performed on the RP C18 column with gradient elution. Results The developed method of LC-MS/MS was used for the quantitative estimation of gallic acid, corilagin acid, caffeic acid, syringic acid, rutin hydrate, ellagic acid, quercetin and morin hydrate in PI, QI and TC. As per method validation parameters, calibration plots were found to be linear, accurate, precise and specific for LC-MS/MS. The calibration plot exhibited an excellent coefficient of determination ( R2 ≥ 0.99), and extraction recovery was found 96.20%–103.71%. Gallic acid and ellagic acid are the most abundant compound among eight targeted polyphenolics in all extracts. Conclusion The finding of LC-MS/MS analysis of polyphenolic compounds in aqueous and hydro-alcoholic extracts indicates that PI, QI and TC are having phytochemical similarities up to an extent in polyphenolic compounds as a secondary metabolite; however, a firmer opinion can be formed after a comparative efficacy study and the evaluation of all three extracts.
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Affiliation(s)
- Anil Kumar Saini
- Dabur Research and Development Centre, Dabur India Limited, Sahibabad, Ghaziabad, Uttar Pradesh, India
| | - Laxman Sawant
- Dabur Research and Development Centre, Dabur India Limited, Sahibabad, Ghaziabad, Uttar Pradesh, India
| | - Sultan Zahiruddin
- Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India
| | - Dhiraj Shrivastva
- Dabur Research and Development Centre, Dabur India Limited, Sahibabad, Ghaziabad, Uttar Pradesh, India
| | - Ranjan Mitra
- Dabur Research and Development Centre, Dabur India Limited, Sahibabad, Ghaziabad, Uttar Pradesh, India
| | - Rajiva Kumar Rai
- Dabur Research and Development Centre, Dabur India Limited, Sahibabad, Ghaziabad, Uttar Pradesh, India
| | - Sayeed Ahmad
- Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India
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13
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Fahimirad S, Satei P, Ganji A, Abtahi H. Wound healing performance of PVA/PCL based electrospun nanofiber incorporated green synthetized CuNPs and Quercus infectoria extracts. JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION 2023; 34:277-301. [PMID: 35993229 DOI: 10.1080/09205063.2022.2116209] [Citation(s) in RCA: 22] [Impact Index Per Article: 11.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/04/2023]
Abstract
In this study, copper nanoparticles (CuNPs) were synthetized through green chemistry approach using C. officinalis flowers extract. The biosynthetized nanoparticles were characterized by FESEM, XRD, DLS and FTIR analysis. Subsequently, PCL nanofiber was fabricated as first supportive layer by electrospinning method. Afterward, PVA/Quercus infectoria galls (QLG) extracts/biosynthetized CuNPs blending solution was electrospinned as second bioactive topical layer. The morphology, physicochemical properties and biological characteristics of the produced PCL, PCL/PVA, PCL/PVA/CuNPs, PCL/PVA/QLG and PCL/PVA/QLG/CuNPs were investigated. Eventually, in vivo wound healing effectiveness was examined. Histologic investigation was carried out for visualization of the healing wounds architecture in different treated groups. FESEM, XRD and DLS assays confirmed the successful synthesis of CuNPs in range of 40-70 nm and FTIR spectrum approve the presence of functional constituents of C. officinalis extract on synthesized CuNPs. The incorporation of CuNPs and QLG extract into PCL/PVA based nanofibers improved their biological capabilities and physicochemical properties. Furthermore, PCL/PVA/QLG/CuNPs illustrated significant wound healing potentials and excellent antibacterial function against at wounds infected with MRSA. Histological assay demonstrated complete wound healing and less inflammation on day 10th. These outcomes recommended the utilization of PCL/PVA/QLG/CuNPs as a novel promising wound dressings with considerable antibacterial features.
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Affiliation(s)
- Shohreh Fahimirad
- Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
| | - Parastu Satei
- Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
| | - Ali Ganji
- Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.,Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
| | - Hamid Abtahi
- Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
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14
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Chaush S, Husain N, Khalid M, Doni M, Khan MQ, Hussain MM. The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial. ADVANCES IN TRADITIONAL MEDICINE 2023; 23:565-573. [PMCID: PMC8819210 DOI: 10.1007/s13596-022-00634-6] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2021] [Accepted: 01/20/2022] [Indexed: 12/19/2022]
Abstract
Hemorrhoidal disease is one of the most common gastrointestinal ailments affecting life quality of the patients. Unani classical literature is replete with anti-hemorrhoidal drugs, but scientific evidence is lacking. Therefore, Safūf Zāj (powdered alum) and Marham-e-Māzū (gall ointment) having potent anti-hemorrhoidal actions were selected to evaluate their efficacy in hemorrhoids. This clinical trial was conducted on 30 participants with hemorrhoids, aged > 18 years. All the participants received Safūf Zāj for sitz baths and Marham-e-Māzū to be applied twice daily for 2 weeks. Primary outcome measures were: change in pain intensity, anal itching, and defecate discomfort assessed on 100 mm VAS scale and per-rectal bleeding assessed on 4-point scale. Secondary outcome measures were: change in the size of the external hemorrhoidal mass assessed on 5-point scale, grade of internal hemorrhoid assessed by Goligher classification and quality of life (QoL) assessed on SF-12 questionnaire. The per-protocol analysis was done on 30 participants and statistically significant improvement was seen in primary and secondary outcome measures. Moreover, both the mental and psychological components of QoL were improved. The study inferred that therapeutic approach of Safūf Zāj and Marham-e-Mazu is safe and efficacious in hemorrhoids. Future studies with well-designed RCTs are highly recommended.
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Affiliation(s)
- Salma Chaush
- Department of ’Ilaj bi’l Tadbir, Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
| | - Nazim Husain
- Department of Medicine (Unani), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
| | - Mohd Khalid
- Department of Medicine (Unani), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
| | - Meenu Doni
- Department of Medicine (Unani), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
| | - Mohd Qudrathullah Khan
- Department of Medicine (Unani), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
| | - Md Majid Hussain
- Department of Medicine (Unani), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101 India
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15
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Evaluating the Effectiveness of Aqueous Extract of Persian Oak (Quercus castaneifolia C.A.Mey.) Fruit Hull on Dermal Wound Healing in the Rat Model. Jundishapur J Nat Pharm Prod 2022. [DOI: 10.5812/jjnpp-127426] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
Background: Persian oak (Quercus castaneifolia C.A.Mey) belongs to the Fagaceae family. This plant is commonly used in Iranian traditional medicine to treat inflammatory and gastric ulcers. Objectives: This study aimed to assess the efficacy of Persian oak fruit aqueous hull extract on wound healing in rats. Methods: Thirty-five male Wistar rats were randomly divided into five groups, then two full-thickness wounds of 10 mm in diameter were created bilaterally on the back of the animals. The negative control group received saline, the positive control group was treated with phenytoin cream, and three treatment groups received 2%, 4%, and 8% Jaft aqueous extract. The animals received these medicines once daily for 15 days. The percentage of wound healing was evaluated using wound contraction ratio, re-epithelialization, tensile strength, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) content. Histopathological examination was performed on repaired tissues. Results: In the 2%, 4%, and 8% Jaft extract and the phenytoin groups, the wound closure rate was significantly higher than in the saline group. The treatment groups revealed significant healing improvement (P < 0.05) compared to the control group in wound contraction, tensile strength, epithelialization duration, VEGF, and PDGF plasma level. Histopathological investigations also exhibited development in wound healing with Jaft extract. Conclusions: This study shows that the Persian oak fruit hull aqueous extract was effective in wound healing in animal models. Clinical trials are required to prove the efficacy of Q. castaneifolia fruit hull spray in healing various wounds in humans.
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Gall Nuts Cynips quercusfolii (Linnaeus) and Andricus infectorius (Hartig) as Tannin Raw Materials. APPLIED SCIENCES-BASEL 2022. [DOI: 10.3390/app12104840] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/04/2023]
Abstract
The study included gall nuts caused by Cynips quercusfolii collected from Quercus robur and Andricus infectorius, harvested from Quercus infectoria. The evaluation of the percentage content of tannins expressed as a pyrogallol was performed using the analytical methodology recommended by the current “European Pharmacopoeia 10”. In order to compare the chemical composition of the tested samples, chromatographic profiles and ion mass distribution spectra were made using high-performance liquid chromatography techniques coupled with two types of detection: spectrophotometry and mass spectrometry. The average content of tannins expressed as pyrogallol for C. quercusfolii ranged from 13.36% to 14.74%, while for A. infectorius it was from 34.77% to 39.95%. The comparison of both the mass spectra and the chromatographic profiles shows a high similarity of all samples of C. quercusfolii and large differences in the chemical composition compared to A. infectorius. The tested C. quercusfolii should be considered a much poorer tannin source than A. infectorius. It cannot be simultaneously treated as its substitute raw material due to the lower tannins percentage content and different chemical composition. However, compared to other Central European herbal raw materials, C. quercusfolii gall nuts are an alternative tannin source with potential use in herbal medicine and the pharmaceutical industry.
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17
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Wan Nor Amilah WAW, Ahmad Najib M, Noor Izani NJ, Arizam MF. Antimicrobial Activities of Quercus infectoria Gall Extracts: A Scoping Review. J Herb Med 2022. [DOI: 10.1016/j.hermed.2022.100543] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/19/2022]
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18
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Elham A, Arken M, Kalimanjan G, Arkin A, Iminjan M. A review of the phytochemical, pharmacological, pharmacokinetic, and toxicological evaluation of Quercus Infectoria galls. JOURNAL OF ETHNOPHARMACOLOGY 2021; 273:113592. [PMID: 33217520 DOI: 10.1016/j.jep.2020.113592] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/04/2020] [Revised: 11/11/2020] [Accepted: 11/12/2020] [Indexed: 06/11/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Quercus Infectoria galls (QIG) have a long history of use in traditional Chinese medicine and traditional Uyghur medicine for the treatment of diarrhea, hemorrhage, skin disease, and many other human ailments. Medicinal applications of QIG have become increasingly popular in Greece, Asia Minor, Syria, and Iran. AIM OF THE REVIEW The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, biological activities, metabolism, pharmacokinetics, toxicology, and drug interactions of QIG to assess the ethnopharmacological uses, explore its therapeutic potential, and identify future opportunities for research. MATERIALS AND METHODS Information on QIG was gathered via the Internet (using Google Scholar, Baidu Scholar, Elsevier, ACS, Pubmed, Web of Science, CNKI, and EMBASE) and libraries. Additionally, information was also obtained from local books and PhD and MS dissertations. RESULTS QIG has played an important role in traditional Chinese medicine. The main bioactive metabolites of QIG include tannins, phenolic acids, flavonoids, triterpenoids, and steroids. Scientific studies on the QIG extract and its components have shown its wide range of pharmacological activities, such as cholinesterase- and monoamine oxidase-inhibitory, antitumor, anti-hypertension, antidiabetic, antimicrobial, insecticidal, antiparasitic, antioxidant, and anti-inflammatory. CONCLUSIONS The ethnopharmacological, phytochemical, pharmacological, and analytical methods of QIG were highlighted in this review, which provides information for future studies and commercial exploration. QIG has a huge potential for pharmaceutical and nutraceutical applications. Moreover, comprehensive toxicity studies of this plant must be conducted to ensure its safety. Additional investigations are recommended to transmute the ethnopharmacological claims of this plant in folklore medicines into scientific rationale-based information. Research on pharmacokinetics studies and potential drug interactions with standard-of-care medications is still limited, which calls for additional studies particularly on humans. Further assessments and clinical trials should be performed before it can be integrated into medicinal practices.
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Affiliation(s)
- Aliya Elham
- Dept. of Pharmaceutics and Physical Chemistry, College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China
| | - Miradel Arken
- Emergency Trauma Center, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Medical University, Urumqi, China
| | - Gulina Kalimanjan
- Dept. of Pharmaceutics and Physical Chemistry, College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China
| | - Abdulaziz Arkin
- Dept. of Pharmaceutics and Physical Chemistry, College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China
| | - Mubarak Iminjan
- Dept. of Pharmaceutics and Physical Chemistry, College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
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Wan-Nor-Amilah WAW, Syifaa'-Liyana ML, Azlina Y, Shafizol Z, Nurul AA. In Vitro Immunomodulatory Activity of Aqueous Quercus infectoria Gall Extract. Oman Med J 2021; 36:e265. [PMID: 34113461 PMCID: PMC8167420 DOI: 10.5001/omj.2021.63] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2019] [Accepted: 09/07/2020] [Indexed: 11/15/2022] Open
Abstract
Objectives Our study reports the immunomodulatory potency of Quercus infectoria gall extract in vitro. The aqueous extract was prepared and examined for its effects on cell proliferation, phagocytic activity, nitric oxide (NO) production, and cytokine synthesis by murine macrophages. Methods Proliferative, phagocytic activity, and NO production of extract-treated and control cells were studied using proliferative assay, flow cytometry, and Griess reaction, respectively. An enzyme-linked immunosorbent assay was performed to determine the levels of pro- and anti-inflammatory cytokines in the macrophage culture. Results Treated macrophages had a higher proliferative rate and phagocytic activity compared to untreated macrophages. The cell treatment with an extract concentration of 64 μg/mL demonstrated a significant decrease in NO production (p < 0.001). An increase in cytokine levels (IL-2, IL-5, IL-10, IL-17A, IL-23, TGF-β1) was observed; however, this increase was not statistically significant. Conclusions Our study suggests that gall extract possesses the potential for augmenting immunomodulatory activity by cellular mediated mechanism and could play a role in regulating the innate immune response.
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Affiliation(s)
| | | | - Yahya Azlina
- School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia
| | - Zainuddin Shafizol
- School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia
| | - Asma Abdullah Nurul
- School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia
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20
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Johnson JB, Broszczak DA, Mani JS, Anesi J, Naiker M. A cut above the rest: oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics. J Pharm Pharmacol 2021; 74:485-502. [PMID: 33822141 DOI: 10.1093/jpp/rgab038] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2020] [Accepted: 02/11/2021] [Indexed: 12/15/2022]
Abstract
OBJECTIVES The pathophysiology of chronic wounds typically involves redox imbalance and inflammation pathway dysregulation, often with concomitant microbial infection. Endogenous antioxidants such as glutathione and tocopherols are notably reduced or absent, indicative of significant oxidative imbalance. However, emerging evidence suggests that polyphenols could be effective agents for the amelioration of this condition. This review aims to summarise the current state of knowledge surrounding redox imbalance in the chronic wound environment and the potential use of polyphenols for the treatment of chronic wounds. KEY FINDINGS Polyphenols provide a multi-faceted approach towards the treatment of chronic wounds. Firstly, their antioxidant activity allows direct neutralisation of harmful free radicals and reactive oxygen species, assisting in restoring redox balance. Upregulation of pro-healing and anti-inflammatory gene pathways and enzymes by specific polyphenols further acts to reduce redox imbalance and promote wound healing actions, such as proliferation, extracellular matrix deposition and tissue remodelling. Finally, many polyphenols possess antimicrobial activity, which can be beneficial for preventing or resolving infection of the wound site. SUMMARY Exploration of this diverse group of natural compounds may yield effective and economical options for the prevention or treatment of chronic wounds.
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Affiliation(s)
- Joel B Johnson
- School of Health, Medical and Applied Science, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia.,Centre for Indigenous Health Equity Research, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia
| | - Daniel A Broszczak
- School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.,Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
| | - Janice S Mani
- School of Health, Medical and Applied Science, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia.,Centre for Indigenous Health Equity Research, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia
| | - Jack Anesi
- School of Science, Psychology and Sport, Federation University Australia, Ballarat, Victoria, Australia
| | - Mani Naiker
- School of Health, Medical and Applied Science, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia.,Centre for Indigenous Health Equity Research, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia
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21
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Khan N, Jamila N, Amin F, Masood R, Atlas A, Khan W, Ain NU, Khan SN. Quantification of macro, micro and trace elements, and antimicrobial activity of medicinal herbs and their products. ARAB J CHEM 2021. [DOI: 10.1016/j.arabjc.2021.103055] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022] Open
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22
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Khatamifar M, Fatemi SJ. Green synthesis of pure copper oxide nanoparticles using Quercus infectoria galls extract, thermal behavior and their antimicrobial effects. PARTICULATE SCIENCE AND TECHNOLOGY 2021. [DOI: 10.1080/02726351.2021.1901810] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/25/2022]
Affiliation(s)
- Marzieh Khatamifar
- Department of Chemistry, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
| | - S. Jamilaldin Fatemi
- Department of Chemistry, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
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Khalilzadeh S, Eftkhar T, Shirbeigi L, Tabarrai M, Toliyat T, Fayazmanesh S, Ghasemi Z, Shamohammadi S. Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial. PHARMACEUTICAL BIOLOGY 2020; 58:574-580. [PMID: 32615837 PMCID: PMC8641665 DOI: 10.1080/13880209.2020.1784236] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/24/2020] [Revised: 06/11/2020] [Accepted: 06/14/2020] [Indexed: 06/11/2023]
Abstract
Context: In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.Objective: This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis.Materials and methods: A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the 'ward' and placebo groups, 46 individuals in each group. The 'ward' group received the 'ward' vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights.Results: Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the 'ward' group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the 'ward' group compared with the placebo group following the intervention and the follow up (p < 0.05).Discussion and conclusions: The findings suggest the 'ward' vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the 'ward' vaginal tablet with common treatments.
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Affiliation(s)
- Somayyeh Khalilzadeh
- Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Tahereh Eftkhar
- Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran
| | - Laila Shirbeigi
- Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Malihe Tabarrai
- Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Tayebeh Toliyat
- Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
| | - Shamim Fayazmanesh
- Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
- Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
| | - Zeinab Ghasemi
- Medical Mycology of Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
| | - Safar Shamohammadi
- Razi Hospital Laboratory, Faculty member in medicine, Tehran University of Medical Sciences, Tehran, Iran
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Askari SF, Jahromi BN, Dehghanian A, Zarei A, Tansaz M, Badr P, Azadi A, Mohagheghzadeh A. Effect of a novel herbal vaginal suppository containing myrtle and oak gall in the treatment of vaginitis: a randomized clinical trial. Daru 2020; 28:603-614. [PMID: 32888185 PMCID: PMC7704832 DOI: 10.1007/s40199-020-00365-6] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/10/2019] [Accepted: 07/30/2020] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Uncomplicated infections such as candidiasis, bacterial vaginosis (BV), or trichomoniasis are easy to diagnose and treat. However, about 8% of patients will have a more complicated course with failure to respond to treatment or rapid recurrence of symptoms. There are many suggestions in Traditional Persian Medicine like myrtle (Myrtus communis L.) and oak gall (Quercus infectoria G.Olivier) for treatment of vaginitis. OBJECTIVES A clinical trial was designed to assess the efficacy of a novel herbal suppository, containing myrtle and oak gall (MOGS) in treatment of vaginitis. METHODS In a parallel randomized clinical trial, 120 women with vaginitis were randomly assigned to MOGS, metronidazole, or placebo. Formulation was simulated from traditional Persian manuscripts and MGOS was prepared after pharmaceutical optimization processing as well as quantification of gallic acid by HPLC. The study was double-blind for MOGS and placebo and single-blind for metronidazole group. RESULTS MOGS effectively improved vaginal discharge (p = 0.024 for BV and 0.018 for trichomoniasis) and pH (compared to placebo (p = 0.013) and metronidazole (p = 0.001)). Both MOGS and metronidazole could reverse whiff test. Metronidazole was the best medication for making Nugent score negative (p = 0.005) as well as the best therapy according to laboratory findings to treat BV in comparison with placebo (p = 0.021). While for trichomoniasis, MOGS could improve the disease more successfully (p = 0.001). Both MOGS and metronidazole treated mixed vaginitis (p = 0.002). CONCLUSION MOGS would be a chance for developing new treatment for trichomoniasis.
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Affiliation(s)
- Sayyede Fatemeh Askari
- Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Bahia Namavar Jahromi
- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Amirreza Dehghanian
- Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Afsoon Zarei
- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Mojgan Tansaz
- Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | - Parmis Badr
- Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Amir Azadi
- Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Abdolali Mohagheghzadeh
- Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
- Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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Rezayat F, Hashempur MH, Tavahen H, Salmanroghani H, Emtiazy M. The efficacy of Ramak (a traditional herbal medicine preparation) for patients with ulcerative colitis: A pilot, randomized, triple-blinded, placebo-controlled clinical trial. Eur J Integr Med 2020. [DOI: 10.1016/j.eujim.2020.101209] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/04/2023]
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Zin NNINM, Mohamad MN, Roslan K, Abdul Wafi S, Abdul Moin NI, Alias A, Zakaria Y, Abu-Bakar N. In Vitro Antimalarial and Toxicological Activities of Quercus infectoria (Olivier) Gall Extracts. Malays J Med Sci 2020; 27:36-50. [PMID: 32863744 PMCID: PMC7444841 DOI: 10.21315/mjms2020.27.4.4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2020] [Accepted: 06/21/2020] [Indexed: 11/25/2022] Open
Abstract
BACKGROUND The spread of Plasmodium falciparum resistance in common antimalarial drugs, including artemisinin-based combination therapies, has necessitated the discovery of new drugs with novel mechanisms of action. In the present study, the in vitro antimalarial and toxicological activities of acetone, methanol, ethanol and aqueous extracts of Quercus infectoria (Q. infectoria) galls were investigated. METHODS The extracts were assessed for the antimalarial potential using a malarial SYBR Green I fluorescence-based (MSF) assay, while the toxicity was screened by using brine shrimp lethality test (BSLT), haemolytic assay, and cytotoxicity assay against normal embryo fibroblast cell line (NIH/3T3) and normal kidney epithelial cell line (Vero). RESULTS The acetone extract showed the highest antimalarial activity (50% inhibitory concentration, IC50 = 5.85 ± 1.64 μg/mL), followed by the methanol extract (IC50 = 10.31 ± 1.90 μg/mL). Meanwhile, the ethanol and aqueous extracts displayed low antimalarial activity with IC50 values of 20.00 ± 1.57 and 30.95 μg/mL ± 1.27 μg/mL, respectively. The significant antimalarial activity was demonstrated in all extracts and artemisinin (P < 0.05). All extracts were non-toxic to brine shrimps (50% lethality concentration, LC50 > 1000 ppm). Furthermore, no occurrence of haemolysis (< 5%) was observed in normal erythrocytes when treated with all extracts compared to Triton X-100 that caused 100% haemolysis (P < 0.05). The acetone and methanol extracts were non-toxic to the normal cell lines and statistically significant to artemisinin (P < 0.05). CONCLUSION Taken together with satisfactory selectivity index (SI) values, the acetone and methanol extracts of Q. infectoria galls could serve as an alternative, promising and safe antimalarial agents.
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Affiliation(s)
| | - Mira Nabila Mohamad
- School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
| | - Keusar Roslan
- School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
| | - Sazeli Abdul Wafi
- Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam
| | - Nurul I'zaaz Abdul Moin
- Department of Biomedical Sciences, Universiti Islam Antarabangsa Malaysia, Kuantan, Pahang, Malaysia
| | - Azamuddin Alias
- Department of Biomedical Sciences, Universiti Islam Antarabangsa Malaysia, Kuantan, Pahang, Malaysia
| | - Yusmazura Zakaria
- School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
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Kang MR, Jo SA, Lee H, Yoon YD, Kwon JH, Yang JW, Choi BJ, Park KH, Lee MY, Lee CW, Lee KR, Kang JS. Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment. Mar Drugs 2020; 18:md18060300. [PMID: 32512874 PMCID: PMC7344946 DOI: 10.3390/md18060300] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/07/2020] [Revised: 05/28/2020] [Accepted: 06/02/2020] [Indexed: 12/19/2022] Open
Abstract
Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-a and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-a and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-kB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IkBa and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-kB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.
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Affiliation(s)
- Moo Rim Kang
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
- Ractigen Therapeutics, Nantong, Jiangsu 226400, China
| | - Sun Ah Jo
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Hyunju Lee
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Yeo Dae Yoon
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Joo-Hee Kwon
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Jeong-Wook Yang
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Byeong Jo Choi
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Ki Hwan Park
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Myeong Youl Lee
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Chang Woo Lee
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Kyeong-Ryoon Lee
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
| | - Jong Soon Kang
- Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea; (M.R.K.); (S.A.J.); (H.L.); (Y.D.Y.); (J.-H.K.); (J.-W.Y.); (B.J.C.); (K.H.P.); (M.Y.L.); (C.W.L.); (K.-R.L.)
- Correspondence: ; Tel.: +82-43-240-6524; Fax: +82-43-240-6529
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Chokpaisarn J, Chusri S, Voravuthikunchai SP. Clinical randomized trial of topical Quercus infectoria ethanolic extract for the treatment of chronic diabetic ulcers. J Herb Med 2020. [DOI: 10.1016/j.hermed.2019.100301] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/02/2023]
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Zin NNINM, Rahimi WNAWM, Bakar NA. A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies. Malays J Med Sci 2020; 26:19-34. [PMID: 31908584 PMCID: PMC6939732 DOI: 10.21315/mjms2019.26.6.3] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/20/2019] [Accepted: 06/21/2019] [Indexed: 12/14/2022] Open
Abstract
Parasitic diseases represent one of the causes for significant global economic, environmental and public health impacts. The efficacy of currently available anti-parasitic drugs has been threatened by the emergence of single drug- or multidrug-resistant parasite populations, vector threats and high cost of drug development. Therefore, the discovery of more potent anti-parasitic drugs coming from medicinal plants such as Quercus infectoria is seen as a major approach to tackle the problem. A systematic review was conducted to assess the efficacy of Q. infectoria in treating parasitic diseases both in vitro and in vivo due to the lack of such reviews on the anti-parasitic activities of this plant. This review consisted of intensive searches from three databases including PubMed, Science Direct and Scopus. Articles were selected throughout the years, limited to English language and fully documented. A total of 454 potential articles were identified, but only four articles were accepted to be evaluated based on inclusion and exclusion criteria. Although there were insufficient pieces of evidence to account for the efficacy of Q. infectoria against the parasites, this plant appears to have anti-leishmanial, anti-blastocystis and anti-amoebic activities. More studies in vitro and in vivo are warranted to further validate the anti-parasitic efficacy of Q. infectoria.
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Zeng Y, Liu J, Tian S. Qualitative and Quantitative Analyses of Gallic Acid and Methyl Gallate in Guyinye Residue Extracts and Turkish Gall Cream by High-Performance Thin-Layer Chromatography. JPC-J PLANAR CHROMAT 2019. [DOI: 10.1556/1006.2019.32.5.3] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/11/2023]
Affiliation(s)
- Ya Zeng
- College of TCM, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
| | - Jiajia Liu
- College of TCM, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
| | - Shuge Tian
- College of TCM, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
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Khalilzadeh S, Eftekhar T, Rahimi R, Mehriardestani M, Tabarrai M. An Evidence-Based Review of Medicinal Plants Used for the Treatment of Vaginitis by Avicenna in " the Canon of Medicine". Galen Med J 2019; 8:e1270. [PMID: 34466482 PMCID: PMC8344152 DOI: 10.31661/gmj.v8i0.1270] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/24/2018] [Revised: 10/07/2018] [Accepted: 12/07/2018] [Indexed: 12/21/2022] Open
Abstract
Vaginitis is one of the most common gynecological problems in reproductive age. Because of the limitations of the conventional drugs, identification of new pharmacological interventions for this disease seems to be necessary. The purpose of this article is to review the medicinal herbs mentioned for the treatment of vaginitis by the great Iranian scientist, Avicenna, in his book "the Canon of Medicine " to scientifically demonstrate their effects and their potential to be used as complementary therapies. The medicinal plants listed for vaginitis treatment in "the Canon of Medicine " were extracted. The scientific name and English common name of the given medicinal plants were searched in databases including PubMed, Scopus, and Cochrane Library until December 2017 to obtain any in vitro, animal, and clinical evidence related to vaginitis. Various pharmacological activities, including anti-inflammatory, wound healing, antimicrobial, antifungal, analgesic, and anti-prostaglandin E2, have been demonstrated for medicinal plants emphasized by Avicenna for vaginitis. Randomized controlled trials (RCTs) on Myrtus reported an improvement in the treatment of bacterial vaginosis. Four RCTs on pomegranate indicated a reduction in inflammatory factors in the patients. Medicinal herbs offered in Herbal Medicine are valuable sources for the treatment of various diseases. Effects and pharmacodynamics having been proved by conventional medicine confirm the effectiveness of these herbs. Therefore, these plants can be used in the treatment of vaginitis thanks to further clinical studies.
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Affiliation(s)
- Somayyeh Khalilzadeh
- Department of Persian medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Tahereh Eftekhar
- Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran
| | - Roja Rahimi
- Department of Traditional Pharmacy, School of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
| | - Mozhgan Mehriardestani
- Department of Traditional Pharmacy, School of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
| | - Malihe Tabarrai
- Department of Persian medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
- Correspondence to: Malihe Tabarrai, School of Persian medicine, Tehran university of Medical Sciences, Gity alley, Vafamanesh St., Heravi Sq., Tehran, Iran Telephone Number: 00989127909906 Email Address:
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Effect of vibrating-type ultrafine grinding on the physicochemical and antioxidant properties of Turkish galls in Uyghur medicine. POWDER TECHNOL 2018. [DOI: 10.1016/j.powtec.2018.07.095] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/19/2022]
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Mbiantcha M, Almas J, Atsamo AD, Ateufack G, Shabana SU, Bomba Tatsinkou DF, Yousseu Nana W, Nida D. Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats. Inflammopharmacology 2018; 26:1383-1398. [PMID: 29948494 DOI: 10.1007/s10787-018-0505-x] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/29/2018] [Accepted: 06/02/2018] [Indexed: 11/24/2022]
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Farghi Yamchi A, Dabirzadeh M, Maroufi Y. In Vitro Effect of Methanolic Extract of Quercus infectoria Galls on Promastigotes and Amastigotes of Leishmania major (MRHO/IR/75/ER). MEDICAL LABORATORY JOURNAL 2018. [DOI: 10.29252/mlj.12.5.23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/31/2022] Open
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Gallnuts: A Potential Treasure in Anticancer Drug Discovery. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018; 2018:4930371. [PMID: 29785193 PMCID: PMC5896229 DOI: 10.1155/2018/4930371] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 09/08/2017] [Revised: 02/17/2018] [Accepted: 02/21/2018] [Indexed: 12/18/2022]
Abstract
Introduction. In the discovery of more potent and selective anticancer drugs, the research continually expands and explores new bioactive metabolites coming from different natural sources. Gallnuts are a group of very special natural products formed through parasitic interaction between plants and insects. Though it has been traditionally used as a source of drugs for the treatment of cancerous diseases in traditional and folk medicinal systems through centuries, the anticancer properties of gallnuts are barely systematically reviewed. Objective. To evidence the traditional uses and phytochemicals and pharmacological mechanisms in anticancer aspects of gallnuts, a literature review was performed. Materials and Methods. The systematic review approach consisted of searching web-based scientific databases including PubMed, Web of Science, and Science Direct. The keywords for searching include gallnut, Galla Chinensis, Rhus chinensis, Rhus potaninii, Rhus punjabensis, nutgall, gall oak, Quercus infectoria, Quercus lusitanica, and galla turcica. Two reviewers extracted papers independently to remove the papers unrelated to the anticancer properties of gallnuts. Patents, abstracts, case reports, and abstracts in symposium and congress were excluded. Results and Conclusion. As a result, 14 articles were eligible to be evaluated. It is primarily evident that gallnuts contain a number of bioactive metabolites, which account for anticancer activities. The phytochemical and pharmacological studies reviewed strongly underpin a fundamental understanding of anticancer properties for gallnuts (Galla Chinensis and Galla Turcica) and support their ongoing clinical uses in China. The further bioactive compounds screening and evaluation, pharmacological investigation, and clinical trials are expected to progress gallnut-based development to finally transform the wild medicinal gallnuts to the valuable authorized anticancer drugs.
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Tayel AA, Ghanem RA, Moussa SH, Fahmi M, Tarjam HM, Ismail N. Skin protectant textiles loaded with fish collagen, chitosan and oak galls extract composite. Int J Biol Macromol 2018; 117:25-29. [PMID: 29800672 DOI: 10.1016/j.ijbiomac.2018.05.150] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2018] [Revised: 05/19/2018] [Accepted: 05/21/2018] [Indexed: 11/26/2022]
Abstract
Skin protection and control of its microbial pathogens are highly important demands; natural biological agents are the ideals for that. Collagen (Cg) was extracted and characterized from skin and scales of Nile tilapia fish (Oreochromis niloticus), chitosan (Cts) was extracted from shrimp shells and extract of oak (Quercus infectoria) galls (OGE) was prepared. The antimicrobial potentialities of extracted agents, Cts and OGE, were qualitatively proved against skin pathogens, Staphylococcus aureus and Candida albicans, including both antibiotic sensitive and resistant strains, neither Cg nor negative control exhibited antimicrobial actions toward examined strain. The entire agents were loaded onto cotton fabrics and evaluated for antimicrobial actions and durability. Loaded textiles with the combined extracts' composite were the most effectual followed by individual treatments with OGE and Cts, respectively. Treated textiles upheld most of their antimicrobial activity after 2 laundering cycles toward all microbial pathogens. This invention could be consequently applied for production of skin protectant and hygienic fabrics.
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Affiliation(s)
- Ahmed A Tayel
- Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, El-Geish St., 33516 Kafrelsheikh City, Egypt.
| | - Reem A Ghanem
- Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, El-Geish St., 33516 Kafrelsheikh City, Egypt
| | - Shaaban H Moussa
- Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt
| | - Mona Fahmi
- Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, El-Geish St., 33516 Kafrelsheikh City, Egypt
| | - Hajar M Tarjam
- Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, El-Geish St., 33516 Kafrelsheikh City, Egypt
| | - Nadia Ismail
- Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, El-Geish St., 33516 Kafrelsheikh City, Egypt
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Abdullah AR, Hapidin H, Abdullah H. The Role of Semipurified Fractions Isolated from Quercus infectoria on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM 2018; 2018:5319528. [PMID: 29861772 PMCID: PMC5971332 DOI: 10.1155/2018/5319528] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/27/2017] [Revised: 02/27/2018] [Accepted: 03/18/2018] [Indexed: 01/03/2023]
Abstract
Background. Quercus infectoria (QI) is a plant used in traditional medicines in Asia. The plant was reported to contain various active phytochemical compounds that have potential to stimulate bone formation. However, the precise mechanism of the stimulation effect of QI on osteoblast has not been elucidated. The present study was carried out to isolate QI semipurified fractions from aqueous QI extract and to delineate the molecular mechanism of QI semipurified fraction that enhanced bone formation by using hFOB1.19 human fetal osteoblast cell model. Methods. Isolation of QI semipurified fractions was established by means of column chromatography and thin layer chromatography. Established QI semipurified fractions were identified using Liquid Chromatography-Mass Spectrometry (LC-MS). Cells were treated with derived QI semipurified fractions and investigated for mineralization deposition and protein expression level of BMP-2, Runx2, and OPN by ELISA followed gene expression analysis of BMP-2 and Runx2 by RT-PCR. Results. Column chromatography isolation and purification yield Fractions A, B, and C. LC-MS analysis reveals the presence of polyphenols in each fraction. Results show that QI semipurified fractions increased the activity and upregulated the gene expression of BMP-2 and Runx2 at day 1, day 3, and day 7. OPN activity increased in cells treated with QI semipurified fractions at day 1 and day 3. Meanwhile, at day 7, expression of OPN decreased in activity. Furthermore, the study showed that combination of Fractions A, B, and C with osteoporotic drug (pamidronate) further increased the activity and upregulated the gene expression of BMP-2 and Runx2. Conclusions. These findings demonstrated that polyphenols from semipurified fractions of QI enhanced bone formation through expression of the investigated bone-related marker that is its potential role when combined with readily available osteoporotic drug.
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Affiliation(s)
- Amira Raudhah Abdullah
- Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
| | - Hermizi Hapidin
- Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
| | - Hasmah Abdullah
- Environmental and Occupational Health Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
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Patel S, Rauf A, Khan H. The relevance of folkloric usage of plant galls as medicines: Finding the scientific rationale. Biomed Pharmacother 2018; 97:240-247. [PMID: 29091872 DOI: 10.1016/j.biopha.2017.10.111] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/03/2017] [Revised: 10/17/2017] [Accepted: 10/21/2017] [Indexed: 10/18/2022] Open
Abstract
Galls, the abnormal growths in plants, induced by virus, bacteria, fungi, nematodes, arthropods, or even other plants, are akin to cancers in fauna. The galls which occur in a myriad of forms are phytochemically-distinct from the normal plant tissues, for these are the sites of tug-of-war, just like the granuloma in animals. To counter the stressors, in the form of the effector proteins of the invaders, the host plants elaborate a large repertoire of metabolites, which they normally will not produce. Perturbation of the jasmonic acid pathway, and the overexpression of auxin, and cytokinin, promote the tissue proliferation and the resultant galls. Though the plant family characteristics and the attackers determine the gall biochemistry, most of the galls are rich in bioactive phytochemicals such as phenolic acids, anthocyanins, purpurogallin, flavonoids, tannins, steroids, triterpenes, alkaloids, lipophilic components (tanshinone) etc. Throughout the long trajectory of evolution, humans have learned to use the galls as therapeutics, much like other plant parts. In diverse cultures, the evidence of folkloric usage of galls abound. Among others, galls from the plant genus like Rhus, Pistacia, Quercus, Terminalia etc. are popular as ethnomedicine. This review mines the literature on galling agents, and the medicinal relevance of galls.
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Affiliation(s)
- Seema Patel
- Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, 92182, USA.
| | - Abdur Rauf
- Department of Chemistry, University of Swabi, Anbar, 23561, K.P.K, Pakistan
| | - Haroon Khan
- Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan
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Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K + Channel Activation Dependent. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017; 2017:6374907. [PMID: 29362589 PMCID: PMC5736925 DOI: 10.1155/2017/6374907] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/14/2017] [Revised: 10/31/2017] [Accepted: 11/13/2017] [Indexed: 01/18/2023]
Abstract
Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2. Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain. NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia. Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS. BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2. The extract also significantly inhibited neuropathic pain induced by vincristine. The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone. The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain. This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway.
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41
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Chokpaisarn J, Chusri S, Amnuaikit T, Udomuksorn W, Voravuthikunchai SP. Potential wound healing activity of Quercus infectoria formulation in diabetic rats. PeerJ 2017; 5:e3608. [PMID: 28761790 PMCID: PMC5527956 DOI: 10.7717/peerj.3608] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/25/2017] [Accepted: 07/03/2017] [Indexed: 01/21/2023] Open
Abstract
Background Quercus infectoria G. Olivier (Fagaceae) nutgalls have been widely employed in traditional Asian medicine for several treatments, especially wounds and skin disorders. However, the effects of this plant on wound healing have not yet been clearly elucidated. This present work was focused on utilization of Quercus infectoria (Qi) as a topical agent for chronic wound treatment. Methods Twenty Qi formulations (QiFs) were pharmaceutically formulated and antibacterial activity of all formulations was performed. The best formulation based on an antibacterial activity was selected for evaluation of wound healing property. Total phenolics, total flavonoids, and an anti-oxidant activity of the selected formulation were also investigated. Wound healing activity was assessed in streptozotocin-induced diabetic rats and control rats. Streptozotocin injection (50 mg/kg) was found to induce marked hyperglycaemia, compared with citrate-injected controls. Two wounds were created on the upper back of each animal. QiF was topically applied three days after wounding to one of the duplicate wounds on each animal and physiological saline (control) was applied to the other. All wounds were cleaned once a day until wound closure. Results QiF10, which exhibited antibacterial and anti-oxidant activities, had the ability to enhance the wound healing process in diabetic rats with abundant cellular infiltration, collagen deposition, and re-epithelialization when compared with the control. Discussion This study suggested that QiF10 could be a novel alternative treatment for diabetic wounds.
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Affiliation(s)
- Julalak Chokpaisarn
- Department of Microbiology and Excellence Research Laboratory of Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, Thailand
| | - Sasitorn Chusri
- Faculty of Traditional Thai Medicine and Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, Thailand
| | - Thanaporn Amnuaikit
- Department of Pharmaceutical Technology and Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand
| | - Wandee Udomuksorn
- Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
| | - Supayang Piyawan Voravuthikunchai
- Department of Microbiology and Excellence Research Laboratory of Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, Thailand
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Mohd Nasir H, Md Salleh L, Ismail AR, Machmudah S. Solubility correlation of gall (Quercus infectoria
) extract in supercritical CO2
using semi-empirical equations. ASIA-PAC J CHEM ENG 2017. [DOI: 10.1002/apj.2118] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/16/2023]
Affiliation(s)
- Hasmida Mohd Nasir
- Bioprocess and Polymer Engineering Department, Faculty of Chemical and Energy Engineering; Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
- Centre of Lipid Engineering and Applied Research (CLEAR), Ibnu Sina Institute for Scientific and Industrial Research (ISIR); Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
| | - Liza Md Salleh
- Bioprocess and Polymer Engineering Department, Faculty of Chemical and Energy Engineering; Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
- Centre of Lipid Engineering and Applied Research (CLEAR), Ibnu Sina Institute for Scientific and Industrial Research (ISIR); Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
| | - Ahmad Ramdan Ismail
- Bioprocess and Polymer Engineering Department, Faculty of Chemical and Energy Engineering; Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
- Centre of Lipid Engineering and Applied Research (CLEAR), Ibnu Sina Institute for Scientific and Industrial Research (ISIR); Universiti Teknologi Malaysia; 81310 UTM Johor Bahru Johor Malaysia
| | - Siti Machmudah
- Department of Chemical Engineering; Sepuluh Nopember Institute of Technology; Surabaya 60111 Indonesia
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Topical co-administration of Pistacia atlantica hull and Quercus infectoria gall hydroethanolic extract improves wound-healing process. ACTA ACUST UNITED AC 2017. [DOI: 10.1007/s00580-017-2473-8] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/27/2023]
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Chokpaisarn J, Urao N, Voravuthikunchai SP, Koh TJ. Quercus infectoria inhibits Set7/NF-κB inflammatory pathway in macrophages exposed to a diabetic environment. Cytokine 2017; 94:29-36. [PMID: 28408068 DOI: 10.1016/j.cyto.2017.04.005] [Citation(s) in RCA: 26] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2016] [Revised: 03/20/2017] [Accepted: 04/03/2017] [Indexed: 01/12/2023]
Abstract
Chronic inflammation plays a key role in the pathogenesis of myriad complications associated with diabetes and thus anti-inflammatory therapies may ameliorate these complications. Quercus infectoria (Qi) extract has been shown to downregulate inflammatory processes; however, the molecular mechanisms of this anti-inflammatory activity remain unclear. The hypothesis of our study was that Qi extract exerts its anti-inflammatory effect by downregulating the Set7/NF-κB pathway. Bone marrow-derived macrophages (BMM) were treated with high glucose plus palmitate medium (HG/Pa) to simulate the diabetic environment. Compared with control conditions, HG/Pa elevated expression Set7, expression and activity of NF-κB along with expression of several inflammatory cytokines. These changes were associated with increased levels of intracellular reactive oxygen species (ROS). Moreover, similar alterations were demonstrated in BMM derived from mice fed a high fat diet (HFD) compared to those from lean mice, suggesting that HFD-induced changes in BM progenitors persist throughout differentiation and culture. Importantly, Qi extract dose-dependently reduced Set7, p65 and inflammatory cytokine expression relative to vehicle controls in both HG/Pa-and HFD-treated BMM. Finally, macrophages/monocytes isolated from wounds of diabetic mice that were treated with Qi solution exhibited lower expression of the inflammatory cytokines, IL-1β and TNF-α, compared with vehicle treated wounds, demonstrating translation to the in vivo diabetic environment. Taken together, data from this study suggests that Qi downregulates diabetes-induced activity of the Set7/NF-kB pathway.
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Affiliation(s)
- Julalak Chokpaisarn
- Department of Microbiology and Excellent Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
| | - Norifumi Urao
- Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
| | - Supayang P Voravuthikunchai
- Department of Microbiology and Excellent Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
| | - Timothy J Koh
- Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
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Effendy NM, Khamis MF, Shuid AN. The effects of Labisia pumila extracts on bone microarchitecture of ovariectomized-induced osteoporosis rats: A micro-CT analysis. JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY 2017; 25:101-112. [PMID: 27768005 DOI: 10.3233/xst-16115] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/06/2023]
Abstract
BACKGOUND Labisia pumila (LP) is a popular herb used by women over the past few decades. This herb has shown potentials as an alternative agent for treatment and prevention of postmenopausal osteoporosis. It was observed in previous studies that supplementation to ovariectomized rats were associated with increased bone antioxidative enzymes and reduced lipid peroxidation activity. It had also improved bone formation markers in ovariectomized rats. This study aimed to evaluate the effects of giving different forms of LP extracts on the trabecular bone microarchitecture of ovariectomised rats. METHODS Forty-eight female Sprague-Dawley rats were randomly divided into sham-operated (Sham), ovariectomized control (OVX), ovariectomized and given estrogen at 64.5 μg/kg (ERT), ovariectomized and given LP aqueous extract (LPaq), LP methanol extract (LPmet) and LP ethanol extract (LPet) at 100 mg/kg, respectively. Treatments were given daily via oral gavages for nine weeks. Following sacrifice, femora were dissected out for bone microarchitectural analysis using an in vitro micro-CT, which provided three dimensional informations on bone microarchitecture. RESULTS LPaq was the most effective extract found to improve the bone microarchitectural paramaters which comprised ofBone volume fraction (BV/TV), Trabecular separation (Tb.Sp), Trabecular number (Tb.N), Connective density (Conn.dens), Structure model index (SMI) and Degree of anisotropy (DA). CONCLUSION LPaq was effective in protecting the bone of postmenopausal osteoporosis rat model against microarchitectural deterioration.
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Affiliation(s)
- Nadia Mohd Effendy
- Faculty of Medicine, Universiti Sains Islam Malaysia, Jalan Pandan Utama, Pandan Indah, Kuala Lumpur, Malaysia
- Department of Pharmacology, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
| | - Mohd Fadhli Khamis
- School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
| | - Ahmad Nazrun Shuid
- Department of Pharmacology, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
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Hadidi L, Babou L, Zaidi F, Valentão P, Andrade PB, Grosso C. Quercus ilex L.: How season, Plant Organ and Extraction Procedure Can Influence Chemistry and Bioactivities. Chem Biodivers 2016; 14. [PMID: 27584870 DOI: 10.1002/cbdv.201600187] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/01/2016] [Accepted: 08/31/2016] [Indexed: 12/11/2022]
Abstract
Quercus species have a plethora of applications, either in wine and wood industries, in human and animal nutrition or in human health. In order to improve the knowledge on this genus, the aim of the present study was to correlate, for the first time, the phenolic composition of different Quercus ilex L. plant tissues (leaves in two maturation stages, acorns, teguments and cotyledons) and different extraction procedures with scavenging and anticholinesterase activities. The hydromethanolic and aqueous extracts obtained showed strong radical scavenging activity against DPPH, superoxide anion radical and nitric oxide radical, leaves exhibiting higher total phenolic content and revealing the best antioxidant properties, followed by tegument and acorns. Concerning the phenolic profile, fifteen compounds were identified and quantified by HPLC-DAD, ranging from 1568.43 to 45,803.16 mg/kg dried extract. The results indicate that Q. ilex can be a source of strong antioxidant phenolic compounds with possible interest for food and pharmaceutical industries.
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Affiliation(s)
- Lila Hadidi
- Department of Physico-Chemical Biology, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, 06000, Algeria
| | - Louiza Babou
- Department of Food Science, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, 06000, Algeria
| | - Farid Zaidi
- Department of Food Science, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, 06000, Algeria
| | - Patrícia Valentão
- REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, no. 228, PT-4050-313, Porto, Portugal
| | - Paula B Andrade
- REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, no. 228, PT-4050-313, Porto, Portugal
| | - Clara Grosso
- REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, no. 228, PT-4050-313, Porto, Portugal
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Moradi MT, Karimi A, Alidadi S. In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions. Chin J Nat Med 2016; 14:196-202. [PMID: 27025366 DOI: 10.1016/s1875-5364(16)30016-4] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2015] [Indexed: 12/16/2022]
Abstract
Cancer cell resistance to widely used chemotherapeutic agents is gradually developed. Natural products, mainly isolated from medicinal plants, have been considered as valuable sources for herbal anticancer drugs. The present study aimed to evaluate in vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract and four fractions of Q. brantii acorn. Crude ethyle alcohole extract of Q. brantii acorn was prepared and subjected to fractionation with different polarity. Subsequently, the extract and the fractions wereevaluated for their in vitro antiproliferative activity in two cancerous (Hela and AGS) and one normal (HDFs) cell lines using MTT [3-(4, 5-dimethylthiazol-2ol) 2, 5 diphenyltetrazoliumbromide] assay. To determine whether the cytotoxicity of these compounds involved the induction of apoptosis, Hela cells were treated with IC50 concentrations of test compounds, stained with both propidium iodide (PI) and Annexin V-fluorescein isothiocyanate (FITC), and analyzed by flow cytometry. In vitro cytotoxicity assay showed that the cell viability was significantly reduced in a dose-dependent manner following treatment with crude ethyle alcohole extract and Cholophorm and n-Butanol fractions. Based on the probit regression model, antiproliferative activities of crude ethyle alcohole extract, Cholophorm fraction, and n-Butanol fraction on Hela and AGS cells and HDFs cells were significantly different (P < 0.001). The results of flow cytometric analysis showed that crude ethyle alcohole extract and two fractions of Q. brantii acorn induced early apoptotic cell death. These findings suggest that crude ethyle alcohole extract and Cholophorm and n-Butanol fractions of Q. brantii acorn suppress the proliferation of cancer cells through induction of early apoptosis.
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Affiliation(s)
- Mohammad-Taghi Moradi
- Student's Research Committee, Shahrekord University of Medical Science, Shahrekord, Iran
| | - Ali Karimi
- Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran.
| | - Somayeh Alidadi
- Clinical Biochemistry Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
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Karimi A, Rafieian-Kopaei M, Moradi MT, Alidadi S. Anti-Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of Quercus brantii L Acorn. J Evid Based Complementary Altern Med 2016; 22:455-461. [PMID: 27899436 PMCID: PMC5871161 DOI: 10.1177/2156587216676421] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/25/2022] Open
Abstract
This research was aimed to evaluate anti–herpes simplex virus type-1 (anti-HSV-1) activity of crude ethanol extract and 4 corresponding fractions of Quercus brantii acorn in vitro. Crude ethanol extract was prepared and subjected to fractionation with different polarity. Anti-HSV-1 activity was evaluated on baby hamster kidney cell line using MTT assay. The inhibitory effect of the plant materials on adsorption and/or post-adsorption stages of HSV-1 replication cycle were determined. Regression analysis was used to determine 50% inhibitory concentration and 50% cytotoxicity concentration, from which selective index was calculated. Based on our results, the chloroform fraction and the crude extract had the highest effect against HSV-1 with selectivity indices of 53.8 and 48.4, respectively. The n-hexane, n-butanol, and chloroform fractions inhibited HSV-1 replication in postadsorption stage (P < .001). The results obtained indicated that the chloroform fraction of Q brantii acorn with high inhibitory effect against HSV-1 replication could be a new promising anti-HSV-1 agent.
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Affiliation(s)
- Ali Karimi
- 1 Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
| | - Mahmoud Rafieian-Kopaei
- 1 Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
| | - Mohammad-Taghi Moradi
- 2 Students Research Committee, Shahrekord University of Medical Science, Shahrekord, Iran
| | - Somayeh Alidadi
- 3 Cellular and Molecular Research Center; Shahrekord University of Medical Science, Shahrekord, Iran
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Vinha AF, Barreira JCM, Costa ASG, Oliveira MBPP. A New Age for Quercus spp. Fruits: Review on Nutritional and Phytochemical Composition and Related Biological Activities of Acorns. Compr Rev Food Sci Food Saf 2016; 15:947-981. [PMID: 33401830 DOI: 10.1111/1541-4337.12220] [Citation(s) in RCA: 56] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/21/2016] [Revised: 06/14/2016] [Accepted: 06/15/2016] [Indexed: 12/15/2022]
Abstract
The current global food system must adapt to the expected growth of world population (about 9 billion individuals by 2050). This adaptation will probably include an increased consumption of edible wild foods, due to their richness in micronutrients and bioactive compounds, besides providing a cost-effective and sustainable way of improving caloric food security. A striking example of such natural matrices is the Quercus genus, which has the additional advantage of being widespread throughout the Northern Hemisphere. In a traditional sense, Quercus fruits (acorns) were mainly used in animal feeding, despite their potentially important role on the rural economy. But this preconception is changing. In fact, their nutritional value, high contents in phytochemical compounds, biological activity (such as antioxidant, anticarcinogenic, and cardioprotective properties) and use in the treatment of specific diseases (such as atherosclerosis, diabetes, or Alzheimer's disease) have raised the interest in integrating acorns into the human diet. Accordingly, this comprehensive overview was designed to provide an evidence-based review of the literature, with the objective to achieve useful conclusions regarding the nutritional properties, methodologies of extraction, identification, and characterization of a wide variety of bioactive compounds and scientifically validated bioactivities in Quercus species worldwide. The industrial by-products from acorn oil extraction or flour production are also included. Data regarding the analytical techniques, individual compounds, and their bioactivities, are organized in tables. The reported data are discussed and directions for further investigations are suggested, highlighting the use of acorns in food, nutraceutical, and pharmaceutical applications.
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Affiliation(s)
- Ana F Vinha
- REQUIMTE/LAQV, Dept. of Chemical Sciences, Faculty of Pharmacy, Univ. of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.,FP-ENAS (UFP Energy, Environment and Health Research Unit), CEBIMED (Biomedical Research Center), Univ. Fernando Pessoa, Praça 9 de Abril, 349, 4249-004, Porto, Portugal
| | - João C M Barreira
- REQUIMTE/LAQV, Dept. of Chemical Sciences, Faculty of Pharmacy, Univ. of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.,Mountain Research Centre (CIMO), ESA, Polytechnic Inst. of Bragança, Campus de Santa Apolónia, 5300-253, Bragança, Portugal
| | - Anabela S G Costa
- REQUIMTE/LAQV, Dept. of Chemical Sciences, Faculty of Pharmacy, Univ. of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal
| | - M Beatriz P P Oliveira
- REQUIMTE/LAQV, Dept. of Chemical Sciences, Faculty of Pharmacy, Univ. of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal
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Veisi H, Hemmati S, Shirvani H, Veisi H. Green synthesis and characterization of monodispersed silver nanoparticles obtained using oak fruit bark extract and their antibacterial activity. Appl Organomet Chem 2016. [DOI: 10.1002/aoc.3444] [Citation(s) in RCA: 52] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022]
Affiliation(s)
- Hamed Veisi
- Department of Chemistry; Payame Noor University; Tehran Iran
| | - Saba Hemmati
- Department of Chemistry; Payame Noor University; Tehran Iran
- Research Center of Oils and Fats; Kermanshah University of Medical Sciences; Kermanshah Iran
| | | | - Hojat Veisi
- Department of Chemistry; Payame Noor University; Tehran Iran
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