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For: Hoensch H, Groh B, Edler L, Kirch W. Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. World J Gastroenterol 2008; 14(14): 2187-2193 [PMID: 18407592 DOI: 10.3748/wjg.14.2187]
URL: https://www.wjgnet.com/1007-9327/full/v14/i14/2187.htm
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Sapna Patel, Michael Vajdy. Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoidsExpert Opinion on Biological Therapy 2015; 15(10): 1411 doi: 10.1517/14712598.2015.1066331
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Akinori Yanaka. Role of NRF2 in protection of the gastrointestinal tract against oxidative stressJournal of Clinical Biochemistry and Nutrition 2018; 63(1): 18 doi: 10.3164/jcbn.17-139
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Sanjeev Shukla, Sanjay Gupta. Apigenin: A Promising Molecule for Cancer PreventionPharmaceutical Research 2010; 27(6): 962 doi: 10.1007/s11095-010-0089-7
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Alina Vrieling, Ellen Kampman. The role of body mass index, physical activity, and diet in colorectal cancer recurrence and survival: a review of the literatureThe American Journal of Clinical Nutrition 2010; 92(3): 471 doi: 10.3945/ajcn.2009.29005
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Héloïse M. Leclair, Nina Tardif, Anaïs Paris, Marie-Dominique Galibert, Sébastien Corre. Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF InhibitorsInternational Journal of Molecular Sciences 2020; 21(14): 5025 doi: 10.3390/ijms21145025
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Cheol Min Shin, Dong Ho Lee, A Young Seo, Hyun Joo Lee, Seong Beom Kim, Woo-Chan Son, Young Kyung Kim, Sang Jun Lee, Sung-Hee Park, Nayoung Kim, Young Soo Park, Hyuk Yoon. Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: A randomized clinical trialClinical Nutrition 2018; 37(2): 452 doi: 10.1016/j.clnu.2017.01.014
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Kazim Husain, Krystal Villalobos-Ayala, Valentina Laverde, Oscar A. Vazquez, Bradley Miller, Samra Kazim, George Blanck, Margaret L. Hibbs, Gerald Krystal, Isra Elhussin, Joakin Mori, Clayton Yates, Tomar Ghansah. Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic CancerCancers 2022; 14(15): 3613 doi: 10.3390/cancers14153613
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Claudia Curcio, Silvia Brugiapaglia, Sara Bulfamante, Laura Follia, Paola Cappello, Francesco Novelli. The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic CancerMolecules 2021; 26(6): 1642 doi: 10.3390/molecules26061642
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Alireza Bahrami, Saeede Jafari, Pegah Rafiei, Sara Beigrezaei, Amir Sadeghi, Azita Hekmatdoost, Bahram Rashidkhani, Ehsan Hejazi. Dietary intake of polyphenols and risk of colorectal cancer and adenoma–A case-control study from IranComplementary Therapies in Medicine 2019; 45: 269 doi: 10.1016/j.ctim.2019.04.011
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Urvashi Langeh, Vishal Kumar, Charan Singh, Arti Singh. Drug-herb combination therapy in cancer managementMolecular Biology Reports 2022; 49(11): 11009 doi: 10.1007/s11033-022-07861-9
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Tingting Zhou, Anquan Zheng, Wenge Zhang, Xiuxiang Lu, Huiyu Chen, Haibo Tan. Concise total syntheses of two flavans and structure revision assisted by quantum NMR calculationsOrganic & Biomolecular Chemistry 2022; 20(20): 4096 doi: 10.1039/D2OB00634K
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Hui Chang, Lin Lei, Yun Zhou, Fayin Ye, Guohua Zhao. Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological StudiesNutrients 2018; 10(7): 950 doi: 10.3390/nu10070950
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Ulku Ozbey, Rukset Attar, Mirna Azalea Romero, Saleh S Alhewairini, Behnaz Afshar, Uteuliev Yerzhan Sabitaliyevich, Lara Hanna‐Wakim, Beraat Ozcelik, Ammad Ahmad Farooqi. Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β‐catenin, JAK‐STAT pathways, and microRNAsJournal of Cellular Biochemistry 2019; 120(2): 1060 doi: 10.1002/jcb.27575
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Yanyan Li, Tao Zhang, Grace Chen. Flavonoids and Colorectal Cancer PreventionAntioxidants 2018; 7(12): 187 doi: 10.3390/antiox7120187
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Ayodeji Ojo Oteyola, Raffaele Pilla, Folasade Adesola Ola-Oladimeji, Omotayo Fagbuaro. Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer TherapeuticsAdvances in Medical Diagnosis, Treatment, and Care 2022; : 72 doi: 10.4018/978-1-7998-9258-8.ch004
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Ana Rodriguez-Mateos, David Vauzour, Christian G. Krueger, Dhanansayan Shanmuganayagam, Jess Reed, Luca Calani, Pedro Mena, Daniele Del Rio, Alan Crozier. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an updateArchives of Toxicology 2014; 88(10): 1803 doi: 10.1007/s00204-014-1330-7
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Thergiory Irrazabal, Bhupesh K. Thakur, Kenneth Croitoru, Alberto Martin. Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic ReviewCellular and Molecular Gastroenterology and Hepatology 2021; 11(4): 1177 doi: 10.1016/j.jcmgh.2020.12.013
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Sanjeev Shukla, Sanjay Gupta. Bioactive Foods in Promoting Health2010; : 663 doi: 10.1016/B978-0-12-374628-3.00041-4
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Sadia Afrin, Francesca Giampieri, Massimiliano Gasparrini, Tamara Y. Forbes-Hernández, Danila Cianciosi, Patricia Reboredo-Rodriguez, Jiaojiao Zhang, Piera Pia Manna, Maria Daglia, Atanas Georgiev Atanasov, Maurizio Battino. Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involvedBiotechnology Advances 2020; 38: 107322 doi: 10.1016/j.biotechadv.2018.11.011
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Yiying Zhao, Qing Jiang. Roles of the Polyphenol–Gut Microbiota Interaction in Alleviating Colitis and Preventing Colitis-Associated Colorectal CancerAdvances in Nutrition 2021; 12(2): 546 doi: 10.1093/advances/nmaa104
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Yi Yang, Maoyuan Zhao, Qixuan Kuang, Fengming You, Yifang Jiang. A comprehensive review of phytochemicals targeting macrophages for the regulation of colorectal cancer progressionPhytomedicine 2024; 128: 155451 doi: 10.1016/j.phymed.2024.155451
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Lei Wang, Mengfan Li, Yu Gu, Junli Shi, Jing Yan, Xin Wang, Bingqing Li, Bangmao Wang, Weilong Zhong, Hailong Cao. Dietary flavonoids–microbiota crosstalk in intestinal inflammation and carcinogenesisThe Journal of Nutritional Biochemistry 2024; 125: 109494 doi: 10.1016/j.jnutbio.2023.109494
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Eswar Shankar, Aditi Goel, Karishma Gupta, Sanjay Gupta. Plant Flavone Apigenin: an Emerging Anticancer AgentCurrent Pharmacology Reports 2017; 3(6): 423 doi: 10.1007/s40495-017-0113-2
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Leila Arfaoui. Dietary Plant Polyphenols: Effects of Food Processing on Their Content and BioavailabilityMolecules 2021; 26(10): 2959 doi: 10.3390/molecules26102959
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Antonio González-Sarrías, Mar Larrosa, María Teresa García-Conesa, Francisco A. Tomás-Barberán, Juan Carlos Espín. Nutraceuticals for older people: Facts, fictions and gaps in knowledgeMaturitas 2013; 75(4): 313 doi: 10.1016/j.maturitas.2013.05.006
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Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope, Nayara A. Artero, Fernanda S. Rasquel-Oliveira, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri. Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical DevelopmentMolecules 2020; 25(3): 762 doi: 10.3390/molecules25030762
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Anaïs Paris, Nina Tardif, Marie-Dominique Galibert, Sébastien Corre. AhR and Cancer: From Gene Profiling to Targeted TherapyInternational Journal of Molecular Sciences 2021; 22(2): 752 doi: 10.3390/ijms22020752
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Simone Jacobs, Brook E Harmon, Nicholas J Ollberding, Lynne R Wilkens, Kristine R Monroe, Laurence N Kolonel, Loic Le Marchand, Carol J Boushey, Gertraud Maskarinec. Among 4 Diet Quality Indexes, Only the Alternate Mediterranean Diet Score Is Associated with Better Colorectal Cancer Survival and Only in African American Women in the Multiethnic CohortThe Journal of Nutrition 2016; 146(9): 1746 doi: 10.3945/jn.116.234237
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Minqian Wang, Jenni Firrman, LinShu Liu, Kit Yam. A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut MicrobiotaBioMed Research International 2019; 2019: 1 doi: 10.1155/2019/7010467
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Beatrice Kölbel, Stefanie Hamacher, Martin Hellmich, Wolfgang Kruis. Low Dietary Flavonoid Consumption Is Associated to Severe Inflammatory Bowel DiseaseGastro Hep Advances 2024; 3(1): 31 doi: 10.1016/j.gastha.2023.08.015
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Jyoti Singh, Yusuf Hussain, Suaib Luqman, Abha Meena. Targeting Ca2+ signalling through phytomolecules to combat cancerPharmacological Research 2019; 146: 104282 doi: 10.1016/j.phrs.2019.104282
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Lu Xu, Mohamed Y. Zaky, Waleed Yousuf, Anwar Ullah, Gehad R. Abdelbaset, Yingqiu Zhang, Osama M. Ahmed, Shuyan Liu, Han Liu. The Anticancer Potential of Apigenin Via ImmunoregulationCurrent Pharmaceutical Design 2021; 27(4): 479 doi: 10.2174/1381612826666200713171137
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Jian-Ge Qiu, Lin Wang, Wen-Jing Liu, Ju-Feng Wang, Er-Jiang Zhao, Feng-Mei Zhou, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Wei Wang, Marie Chia-mi Lin, Ling-Zhi Liu, Ying-Xue Huang, Bing-Hua Jiang. Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal CarcinogenesisFrontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.01002
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Mingchuan Wang, Xianjun Liu, Tong Chen, Xianbin Cheng, Huijie Xiao, Xianglong Meng, Yang Jiang. Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathwaysFrontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.956793
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Cíntia Reis Ballard, Mário Roberto Maróstica. Bioactive Compounds2019; : 185 doi: 10.1016/B978-0-12-814774-0.00010-4
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Suat Erdogan, Kader Turkekul, Ilker Dibirdik, Zeynep B. Doganlar, Oguzhan Doganlar, Ayhan Bilir. Midkine silencing enhances the anti–prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-κBInvestigational New Drugs 2020; 38(2): 246 doi: 10.1007/s10637-019-00774-8
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Paola Lasso, Alejandra Gomez-Cadena, Claudia Urueña, Alena Donda, Amaia Martinez-Usatorre, Alfonso Barreto, Pedro Romero, Susana Fiorentino. Prophylactic vs. Therapeutic Treatment With P2Et Polyphenol-Rich Extract Has Opposite Effects on Tumor GrowthFrontiers in Oncology 2018; 8 doi: 10.3389/fonc.2018.00356
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Sara M. Schmitt, Rahul R. Deshmukh, Q. Ping Dou. Resistance to Proteasome Inhibitors in CancerResistance to Targeted Anti-Cancer Therapeutics 2014; : 1 doi: 10.1007/978-3-319-06752-0_1
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Khin Maung Lwin, Ye Htut Linn, Yamin Kyaw Swar Dee. Ampullary Adenocarcinoma: a Mini-Review and a Case Report of a Clinically Stable Disease Patient Treated with Herbal SupplementsJournal of Gastrointestinal Cancer 2021; 52(2): 750 doi: 10.1007/s12029-020-00501-0
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Colinda C.J.M. Simons, Laura A.E. Hughes, Ilja C.W. Arts, R. Alexandra Goldbohm, Piet A. van den Brandt, Matty P. Weijenberg. Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort StudyInternational Journal of Cancer 2009; 125(12): 2945 doi: 10.1002/ijc.24645
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Moein Adel, Masoumeh Zahmatkeshan, Abolfazl Akbarzadeh, Navid Rabiee, Sepideh Ahmadi, Peyman Keyhanvar, Seyed Mahdi Rezayat, Alexander Marcus Seifalian. Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticlesBiotechnology Reports 2022; 34: e00730 doi: 10.1016/j.btre.2022.e00730
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Imen Nasri, Rachid Chawech, Cynthia Girardi, Emmanuel Mas, Audrey Ferrand, Nathalie Vergnolle, Nicolas Fabre, Raoudha Mezghani-Jarraya, Claire Racaud-Sultan. Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cellsPharmaceutical Biology 2017; 55(1): 124 doi: 10.1080/13880209.2016.1230877
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Robert A. Ronzio. Textbook of Natural Medicine2020; : 731 doi: 10.1016/B978-0-323-43044-9.00097-2
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Harald P Hoensch, Reinhard Oertel. Emerging role of bioflavonoids in gastroenterology: Especially their effects on intestinal neoplasiaWorld Journal of Gastrointestinal Oncology 2011; 3(5): 71-74 doi: 10.4251/wjgo.v3.i5.71
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Akram Taleghani, Zahra Tayarani-Najaran. Potent Cytotoxic Natural Flavonoids: The Limits of PerspectiveCurrent Pharmaceutical Design 2019; 24(46): 5555 doi: 10.2174/1381612825666190222142537
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Khashayar Afshari, Nazgol‐Sadat Haddadi, Arvin Haj‐Mirzaian, Mohammad Hosein Farzaei, Mohammad Mojtaba Rohani, Freshteh Akramian, Rozita Naseri, Antoni Sureda, Negar Ghanaatian, Amir Hossein Abdolghaffari. Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studiesJournal of Cellular Physiology 2019; 234(12): 21519 doi: 10.1002/jcp.28777
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Maria Condello, Evelin Pellegrini, Enrico Pierluigi Spugnini, Alfonso Baldi, Bruno Amadio, Bruno Vincenzi, Giovanni Occhionero, Sebastiano Delfine, Franco Mastrodonato, Stefania Meschini. Anticancer activity of “Trigno M”, extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer modelsBiomedicine & Pharmacotherapy 2019; 118: 109281 doi: 10.1016/j.biopha.2019.109281
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Reinhard Saller, Jörg Melzer, Matthias Rostock. Antiinflammatorisch wirksame Phytotherapeutika und ihr mögliches Potential bei tumorkranken MenschenForschende Komplementärmedizin / Research in Complementary Medicine 2011; 18(4): 203 doi: 10.1159/000333140
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Sareshma Sudhesh Dev, Reyhaneh Farghadani, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu. Flavonoids as receptor tyrosine kinase inhibitors in lung cancerJournal of Functional Foods 2023; 110: 105845 doi: 10.1016/j.jff.2023.105845
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Semim Akhtar Ahmed, Dey Parama, Enush Daimari, Sosmitha Girisa, Kishore Banik, Choudhary Harsha, Uma Dutta, Ajaikumar B. Kunnumakkara. Rationalizing the therapeutic potential of apigenin against cancerLife Sciences 2021; 267: 118814 doi: 10.1016/j.lfs.2020.118814
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Bahare Salehi, Alessandro Venditti, Mehdi Sharifi-Rad, Dorota Kręgiel, Javad Sharifi-Rad, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana Souto, Ettore Novellino, Hubert Antolak, Elena Azzini, William Setzer, Natália Martins. The Therapeutic Potential of ApigeninInternational Journal of Molecular Sciences 2019; 20(6): 1305 doi: 10.3390/ijms20061305
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Teresa T. Fung, Rutendo Kashambwa, Kaori Sato, Stephanie E. Chiuve, Charles S. Fuchs, Kana Wu, Edward Giovannucci, Shuji Ogino, Frank B. Hu, Jeffrey A. Meyerhardt, Chung-Jung Chiu. Post Diagnosis Diet Quality and Colorectal Cancer Survival in WomenPLoS ONE 2014; 9(12): e115377 doi: 10.1371/journal.pone.0115377
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Allison Walter, Nelly Etienne‐Selloum, David Brasse, Hadeel Khallouf, Christian Bronner, Marie‐Christine Rio, Alain Beretz, Valérie B. Schini‐Kerth. Intake of grape‐derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosisThe FASEB Journal 2010; 24(9): 3360 doi: 10.1096/fj.09-149419
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Lingyu Wang, Ruolan Li, Qing Zhang, Jia Liu, Ting Tao, Ting Zhang, Chunjie Wu, Qiang Ren, Xufeng Pu, Wei Peng. Pyracantha fortuneana (Maxim.) Li: A comprehensive review of its phytochemistry, pharmacological properties, and product developmentFrontiers in Sustainable Food Systems 2022; 6 doi: 10.3389/fsufs.2022.940900
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Hyeon-Muk Oh, Chong-Kwan Cho, Nam-Hun Lee, Chang-Gue Son. Experimental evidence for anti-metastatic actions of apigenin: a mini reviewFrontiers in Oncology 2024; 14 doi: 10.3389/fonc.2024.1380194
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Paola D. D. S. Maia, Diego dos Santos Baião, Hayandra F. Nanini, Victor Paulo F. da Silva, Lissa Bantim Frambach, Iuri Matheus Cabral, Beatriz Pêgo, Beatriz E. Ribeiro, Mauro Sérgio Gonçalves Pavão, Vania M. F. Paschoalin, Heitor S. P. de Souza, Anna Paola T. R. Pierucci. Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c MiceMolecules 2022; 27(4): 1194 doi: 10.3390/molecules27041194
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Tian-hao Guo, Yuan-yuan Li, Sheng-wei Hong, Qian-yu Cao, Heng Chen, Yuan Xu, Guo-liang Dai, Gang Shao. Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal CancerChinese Journal of Integrative Medicine 2022; 28(10): 939 doi: 10.1007/s11655-022-3466-2
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Nuria Mut-Salud, Pablo Juan Álvarez, Jose Manuel Garrido, Esther Carrasco, Antonia Aránega, Fernando Rodríguez-Serrano. Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal ResultsOxidative Medicine and Cellular Longevity 2016; 2016: 1 doi: 10.1155/2016/6719534
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Gian Luigi Russo, Idolo Tedesco, Carmela Spagnuolo, Maria Russo. Antioxidant polyphenols in cancer treatment: Friend, foe or foil?Seminars in Cancer Biology 2017; 46: 1 doi: 10.1016/j.semcancer.2017.05.005
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Om Prakash, Shazia Usmani, Amresh Gupta, Ruchi Singh, Namrata Singh, Akash Ved. Bioactive Polyphenols as Promising Natural Medicinal Agents Against Cancer: The Emerging Trends and Prospective GoalsCurrent Bioactive Compounds 2020; 16(3): 243 doi: 10.2174/1573407214666181030122046
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Sandra Utz, Miriam Bittel, Jost Langhorst. Phytotherapeutische Empfehlungen in medizinischen Leitlinien zur Behandlung gastroenterologischer Erkrankungen – ein systematischer ÜberblickZeitschrift für Gastroenterologie 2024;  doi: 10.1055/a-2279-5045
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Marco Giammanco, Fulvio Plescia, Manfredi M. Giammanco, Gaetano Leto, Carla Gentile. Bioactive effects of citrus flavonoids and role in the prevention of atherosclerosis and cancerJournal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale 2022; 95(1) doi: 10.4081/jbr.2022.10313
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Jianguo Wu, Jun Yi, Yanbin Wu, Xuzheng Chen, Jianwei Zeng, Jinzhong Wu, Wei Peng. 3, 3-Dimethylquercetin Inhibits the Proliferation of Human Colon Cancer RKO Cells through Inducing G2/M Cell Cycle Arrest and ApoptosisAnti-Cancer Agents in Medicinal Chemistry 2019; 19(3): 402 doi: 10.2174/1871520618666181106120718
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Qijing Wu, Wei Li, Jing Zhao, Wei Sun, Qianqian Yang, Chong Chen, Ping Xia, Jingjing Zhu, Yiceng Zhou, Guoshun Huang, Chen Yong, Min Zheng, Enchao Zhou, Kun Gao. Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammationBiomedicine & Pharmacotherapy 2021; 137: 111308 doi: 10.1016/j.biopha.2021.111308
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