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Number Cited Articles
1
Nicole Mika, Holger Zorn, Martin Rühl. Prolyl-specific peptidases for applications in food protein hydrolysisApplied Microbiology and Biotechnology 2015; 99(19): 7837 doi: 10.1007/s00253-015-6838-0
2
Valli De Re, Raffaella Magris, Renato Cannizzaro. New Insights into the Pathogenesis of Celiac DiseaseFrontiers in Medicine 2017; 4 doi: 10.3389/fmed.2017.00137
3
Bartosz Brzozowski. Impact of food processing and simulated gastrointestinal digestion on gliadin immunoreactivity in rollsJournal of the Science of Food and Agriculture 2018; 98(9): 3363 doi: 10.1002/jsfa.8847
4
Antonio Di Sabatino, Marco Vincenzo Lenti, Paolo Giuffrida, Alessandro Vanoli, Gino Roberto Corazza. New insights into immune mechanisms underlying autoimmune diseases of the gastrointestinal tractAutoimmunity Reviews 2015; 14(12): 1161 doi: 10.1016/j.autrev.2015.08.004
5
Justin L McCarville, Alberto Caminero, Elena F Verdu. Pharmacological approaches in celiac diseaseCurrent Opinion in Pharmacology 2015; 25: 7 doi: 10.1016/j.coph.2015.09.002
6
Philipp Lapuhs, Gregor Fuhrmann. Therapeutic Enzymes: Function and Clinical ImplicationsAdvances in Experimental Medicine and Biology 2019; 1148: 151 doi: 10.1007/978-981-13-7709-9_8
7
Mauro Bozzola, Federico Manai, Chiara Montalbano, Alberto Azzalin, Elena Bozzola, Alberto Villani, Sergio Comincini. Celiac Disease - From the Bench to the Clinic2019;  doi: 10.5772/intechopen.80692
8
Sheila E. Crowe. Management of Celiac Disease: Beyond the Gluten-Free DietGastroenterology 2014; 146(7): 1594 doi: 10.1053/j.gastro.2014.04.027
9
Kalle Kurppa, Minna Hietikko, Ana-Marija Sulic, Katri Kaukinen, Katri Lindfors. Current status of drugs in development for celiac diseaseExpert Opinion on Investigational Drugs 2014; 23(8): 1079 doi: 10.1517/13543784.2014.916274
10
Julia König, Savanne Holster, Maaike J. Bruins, Robert J. Brummer. Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal settingScientific Reports 2017; 7(1) doi: 10.1038/s41598-017-13587-7
11
Satya Kurada, Abhijeet Yadav, Daniel A. Leffler. Current and novel therapeutic strategies in celiac diseaseExpert Review of Clinical Pharmacology 2016; 9(9): 1211 doi: 10.1080/17512433.2016.1200463
12
Karol Sestak, Hazel Thwin, Jason Dufour, Pyone Aye, David Liu, Charles Moehs. The Effects of Reduced Gluten Barley Diet on Humoral and Cell-Mediated Systemic Immune Responses of Gluten-Sensitive Rhesus MacaquesNutrients 2015; 7(3): 1657 doi: 10.3390/nu7031657
13
Karol Sestak, Hazel Thwin, Jason Dufour, David Liu, Xavier Alvarez, David Laine, Adam Clarke, Anthony Doyle, Pyone Aye, James Blanchard, Charles Moehs. Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive MacaquesNutrients 2016; 8(7): 401 doi: 10.3390/nu8070401
14
Nicholas M. Plugis, Chaitan Khosla. Therapeutic approaches for celiac diseaseBest Practice & Research Clinical Gastroenterology 2015; 29(3): 503 doi: 10.1016/j.bpg.2015.04.005
15
James Haridy, Diana Lewis, Evan D. Newnham. Investigational drug therapies for coeliac disease – where to from here?Expert Opinion on Investigational Drugs 2018; 27(3): 225 doi: 10.1080/13543784.2018.1438407
16
Miguel Ribeiro, Fernando M. Nunes, Marta Rodriguez-Quijano, Jose Maria Carrillo, Gérard Branlard, Gilberto Igrejas. Next-generation therapies for celiac disease: The gluten-targeted approachesTrends in Food Science & Technology 2018; 75: 56 doi: 10.1016/j.tifs.2018.02.021
17
Deepak Chellan, Gaurav Muktesh, Kim Vaiphei, Neha Berry, Narendra Dhaka, Saroj Kant Sinha, Babu Ram Thapa, Rakesh Kochhar. Effect of gluten‐free diet and compliance on quality of life in pediatric celiac disease patientsJGH Open 2019; 3(5): 388 doi: 10.1002/jgh3.12172
18
Šárka O. Southern, Mark A. Mentzer, Isaac Rodriguez-Chavez, Virginia E. Wotring, Eva J. Helmerhorst, Guoxian Wei. Experimental strategy to discover microbes with gluten-degrading enzyme activitiesSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV 2014; 9112: 91120D doi: 10.1117/12.2058730
19
Dominique Turck, Jean‐Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather‐Tait, Marina Heinonen, Karen‐Ildico Hirsch‐Ernst, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Monika Neuhäuser‐Berthold, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Daniel Tomé, Marco Vinceti, Peter Willatts, Karl‐Heinz Engel, Rosangela Marchelli, Annette Pöting, Morten Poulsen, Josef Schlatter, Wolfgang Gelbmann, Henk Van Loveren. Safety of proline‐specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97EFSA Journal 2017; 15(2) doi: 10.2903/j.efsa.2017.4681
20
Jason A. Tye-Din, Heather J. Galipeau, Daniel Agardh. Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel TherapiesFrontiers in Pediatrics 2018; 6 doi: 10.3389/fped.2018.00350
21
Hiroki Ido, Hirotaka Matsubara, Manabu Kuroda, Akiko Takahashi, Yuzo Kojima, Satoshi Koikeda, Makoto Sasaki. Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover StudyClinical and Translational Gastroenterology 2018; 9(9): e181 doi: 10.1038/s41424-018-0052-1
22
Daniel C Adelman, Joseph Murray, Tsung-Teh Wu, Markku Mäki, Peter H Green, Ciarán P Kelly. Measuring Change In Small Intestinal Histology In Patients With Celiac DiseaseAmerican Journal of Gastroenterology 2018; 113(3): 339 doi: 10.1038/ajg.2017.480
23
Joshua P. Taylor, Fritz Jacob, Emanuele Zannini, Elke K. Arendt. Reduction of Hordein Content in Beer by Applying Prolyl Endoprotease to the Malting ProcessJournal of the American Society of Brewing Chemists 2017; 75(3): 262 doi: 10.1094/ASBCJ-2017-3072-01
24
Marco Gobbetti, Erica Pontonio, Pasquale Filannino, Carlo Giuseppe Rizzello, Maria De Angelis, Raffaella Di Cagno. How to improve the gluten-free diet: The state of the art from a food science perspectiveFood Research International 2018; 110: 22 doi: 10.1016/j.foodres.2017.04.010
25
Julie Zhu, Chris J J Mulder, Levinus A Dieleman. Celiac Disease: Against the Grain in GastroenterologyJournal of the Canadian Association of Gastroenterology 2019; 2(4): 161 doi: 10.1093/jcag/gwy042
26
Rakhi Panda, Eric A. E. Garber. Detection and Quantitation of Gluten in Fermented-Hydrolyzed Foods by Antibody-Based Methods: Challenges, Progress, and a Potential Path ForwardFrontiers in Nutrition 2019; 6 doi: 10.3389/fnut.2019.00097
27
Michiel Akeroyd, Sylvie van Zandycke, Joost den Hartog, Jozé Mutsaers, Luppo Edens, Marco van den Berg, Chantal Christis. AN-PEP, Proline-Specific Endopeptidase, Degrades All Known Immunostimulatory Gluten Peptides in Beer Made from Barley MaltJournal of the American Society of Brewing Chemists 2016; 74(2): 91 doi: 10.1094/ASBCJ-2016-2300-01
28
Peter H.R. Green, Benjamin Lebwohl, Ruby Greywoode. Celiac diseaseJournal of Allergy and Clinical Immunology 2015; 135(5): 1099 doi: 10.1016/j.jaci.2015.01.044
29
Miguel Ángel López Casado, Pedro Lorite, Candelaria Ponce de León, Teresa Palomeque, Maria Isabel Torres. Celiac Disease AutoimmunityArchivum Immunologiae et Therapiae Experimentalis 2018; 66(6): 423 doi: 10.1007/s00005-018-0520-z
30
R.M. Duar, K.J. Clark, P.B. Patil, C. Hernández, S. Brüning, T.E. Burkey, N. Madayiputhiya, S.L. Taylor, J. Walter. Identification and characterization of intestinal lactobacilli strains capable of degrading immunotoxic peptides present in glutenJournal of Applied Microbiology 2015; 118(2): 515 doi: 10.1111/jam.12687
31
Hugh James Freeman. Emerging drugs for celiac diseaseExpert Opinion on Emerging Drugs 2015; 20(1): 129 doi: 10.1517/14728214.2015.985204
32
Julia König, Robert J. Brummer. Is an enzyme supplement for celiac disease finally on the cards?Expert Review of Gastroenterology & Hepatology 2018; 12(6): 531 doi: 10.1080/17474124.2018.1473762
33
Martial Rey, Menglin Yang, Linda Lee, Ye Zhang, Joey G. Sheff, Christoph W. Sensen, Hynek Mrazek, Petr Halada, Petr Man, Justin L McCarville, Elena F. Verdu, David C. Schriemer. Addressing proteolytic efficiency in enzymatic degradation therapy for celiac diseaseScientific Reports 2016; 6(1) doi: 10.1038/srep30980
34
Simona Gatti, Matilde Rossi, Simona Alfonsi, Alessandra Mandolesi, Giovanni Cobellis, Carlo Catassi. Beyond the Intestinal Celiac Mucosa: Diagnostic Role of Anti-TG2 Deposits, a Systematic ReviewFrontiers in Medicine 2014; 1 doi: 10.3389/fmed.2014.00009
35
Na Tian, Guoxian Wei, Detlef Schuppan, Eva J. Helmerhorst. Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac diseaseAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2014; 307(8): G769 doi: 10.1152/ajpgi.00144.2014
36
B. N. Salden, V. Monserrat, F. J. Troost, M. J. Bruins, L. Edens, R. Bartholomé, G. R. Haenen, B. Winkens, F. Koning, A. A. Masclee. Randomised clinical study:Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteersAlimentary Pharmacology & Therapeutics 2015; 42(3): 273 doi: 10.1111/apt.13266
37
Katharina Anne Scherf, Herbert Wieser, Peter Koehler. Novel approaches for enzymatic gluten degradation to create high-quality gluten-free productsFood Research International 2018; 110: 62 doi: 10.1016/j.foodres.2016.11.021
38
Warren M. Miner-Williams, Paul J. Moughan. Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowelNutrition Research Reviews 2016; 29(1): 40 doi: 10.1017/S0954422416000019
39
Jonas F Ludvigsson, Carolina Ciacci, Peter HR Green, Katri Kaukinen, Ilma R Korponay-Szabo, Kalle Kurppa, Joseph A Murray, Knut Erik Aslaksen Lundin, Markku J Maki, Alina Popp, Norelle R Reilly, Alfonso Rodriguez-Herrera, David S Sanders, Detlef Schuppan, Sarah Sleet, Juha Taavela, Kristin Voorhees, Marjorie M Walker, Daniel A Leffler. Outcome measures in coeliac disease trials: the Tampere recommendationsGut 2018; 67(8): 1410 doi: 10.1136/gutjnl-2017-314853
40
Diana Linke. Enzymatic prevention of health risks in foodCurrent Opinion in Food Science 2015; 1: 21 doi: 10.1016/j.cofs.2014.09.004
41
Alberto Caminero, Heather J. Galipeau, Justin L. McCarville, Chad W. Johnston, Steve P. Bernier, Amy K. Russell, Jennifer Jury, Alexandra R. Herran, Javier Casqueiro, Jason A. Tye-Din, Michael G. Surette, Nathan A. Magarvey, Detlef Schuppan, Elena F. Verdu. Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and ImmunogenicityGastroenterology 2016; 151(4): 670 doi: 10.1053/j.gastro.2016.06.041
42
Fatma Boukid, Mondher Mejri, Nicoletta Pellegrini, Stefano Sforza, Barbara Prandi. How Looking for Celiac-Safe Wheat Can Influence Its Technological PropertiesComprehensive Reviews in Food Science and Food Safety 2017; 16(5): 797 doi: 10.1111/1541-4337.12288
43
Gopal Veeraraghavan, Daniel A Leffler, Dharmesh H Kaswala, Rupa Mukherjee. Celiac disease 2015 update: new therapiesExpert Review of Gastroenterology & Hepatology 2015; 9(7): 913 doi: 10.1586/17474124.2015.1033399
44
Oleg I. Klychnikov, Tatiana M. Shamorkina, Stephen D. Weeks, Hans C. van Leeuwen, Jeroen Corver, Jan W. Drijfhout, Peter A. van Veelen, Nikolai N. Sluchanko, Sergei V. Strelkov, Paul J. Hensbergen. Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP familyJournal of Biological Chemistry 2018; 293(28): 11154 doi: 10.1074/jbc.RA118.003244
45
Claudia E. Osorio, Nuan Wen, Jaime H. Mejias, Bao Liu, Stephen Reinbothe, Diter von Wettstein, Sachin Rustgi. Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac diseaseFunctional & Integrative Genomics 2019; 19(1): 123 doi: 10.1007/s10142-018-0632-x
46
Maaike Bruins. The Clinical Response to Gluten Challenge: A Review of the LiteratureNutrients 2013; 5(11): 4614 doi: 10.3390/nu5114614
47
Stefania Picascia, Roberta Mandile, Renata Auricchio, Riccardo Troncone, Carmen Gianfrani. Gliadin-Specific T-Cells Mobilized in the Peripheral Blood of Coeliac Patients by Short Oral Gluten Challenge: Clinical ApplicationsNutrients 2015; 7(12): 10020 doi: 10.3390/nu7125515
48
Peter D Mooney, Marios Hadjivassiliou, David S Sanders. Emerging drugs for coeliac diseaseExpert Opinion on Emerging Drugs 2014; 19(4): 533 doi: 10.1517/14728214.2014.959490
49
Shakira Yoosuf, Govind K. Makharia. Evolving Therapy for Celiac DiseaseFrontiers in Pediatrics 2019; 7 doi: 10.3389/fped.2019.00193
50
Liana Tsiatsiani, Michiel Akeroyd, Maurien Olsthoorn, Albert J. R. Heck. Aspergillus nigerProlyl Endoprotease for Hydrogen–Deuterium Exchange Mass Spectrometry and Protein Structural StudiesAnalytical Chemistry 2017; 89(15): 7966 doi: 10.1021/acs.analchem.7b01161
51
Juha Taavela, Keijo Viiri, Alina Popp, Mikko Oittinen, Valeriia Dotsenko, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Markku Mäki, Jorma Isola. Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsiesBMC Gastroenterology 2019; 19(1) doi: 10.1186/s12876-019-1089-7
52
Rakhi Panda, Katherine L. Fiedler, Chung Y. Cho, Raymond Cheng, Whitney L. Stutts, Lauren S. Jackson, Eric A. E. Garber. Effects of a Proline Endopeptidase on the Detection and Quantitation of Gluten by Antibody-Based Methods during the Fermentation of a Model Sorghum BeerJournal of Agricultural and Food Chemistry 2015; 63(48): 10525 doi: 10.1021/acs.jafc.5b04205
53
W. J. Canestaro, T. C. Edwards, D. L. Patrick. Systematic review: patient-reported outcome measures in coeliac disease for regulatory submissionsAlimentary Pharmacology & Therapeutics 2016; 44(4): 313 doi: 10.1111/apt.13703
54
Guoxian Wei, Na Tian, Roland Siezen, Detlef Schuppan, Eva J. Helmerhorst. Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac diseaseAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2016; 311(3): G571 doi: 10.1152/ajpgi.00185.2016
55
Karen M. Lammers, Maria G. Herrera, Veronica I. Dodero. Translational Chemistry Meets Gluten-Related DisordersChemistryOpen 2018; 7(3): 217 doi: 10.1002/open.201700197
56
Guoxian Wei, Na Tian, Adriana C Valery, Yi Zhong, Detlef Schuppan, Eva J Helmerhorst. Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac DiseaseAmerican Journal of Gastroenterology 2015; 110(6): 899 doi: 10.1038/ajg.2015.97
57
Henrik Toft-Hansen, Karina S. Rasmussen, Anne Staal, Erwin L. Roggen, Ludvig M. Sollid, Søren T. Lillevang, Torben Barington, Steffen Husby. Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac diseaseClinical Immunology 2014; 153(2): 323 doi: 10.1016/j.clim.2014.05.009
58
George Janssen, Chantal Christis, Yvonne Kooy-Winkelaar, Luppo Edens, Drew Smith, Peter van Veelen, Frits Koning, Karol Sestak. Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme SupplementsPLOS ONE 2015; 10(6): e0128065 doi: 10.1371/journal.pone.0128065
59
Luis Vaquero, David Bernardo, Francisco León, Laura Rodríguez-Martín, Begoña Alvarez-Cuenllas, Santiago Vivas. Challenges to drug discovery for celiac disease and approaches to overcome themExpert Opinion on Drug Discovery 2019; 14(10): 957 doi: 10.1080/17460441.2019.1642321
60
K. Gottlieb, J. Dawson, F. Hussain, J. A. Murray. Development of drugs for celiac disease: review of endpoints for Phase 2 and 3 trialsGastroenterology Report 2015; 3(2): 91 doi: 10.1093/gastro/gov006
61
Manida Wungjiranirun, Ciaran P Kelly, Daniel A Leffler. Current Status of Celiac Disease Drug DevelopmentAmerican Journal of Gastroenterology 2016; 111(6): 779 doi: 10.1038/ajg.2016.105