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For: Montalto M, Curigliano V, Santoro L, Vastola M, Cammarota G, Manna R, Gasbarrini A, Gasbarrini G. Management and treatment of lactose malabsorption. World J Gastroenterol 2006; 12(2): 187-191 [PMID: 16482616 DOI: 10.3748/wjg.v12.i2.187]
URL: https://www.wjgnet.com/1007-9327/full/v12/i2/187.htm
Number Citing Articles
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Khaoula Gharbi, Slimen Selmi, Soumaya Wahabi, Hanen Kahlaoui, Karima Tlili, Stefano D'allacqua, Hichem Sebai. Gastroprotective Effects of Nettle‐ and Carob‐Enriched Snail Mucus in a Rat Model of Gastric Injury: Role of Antioxidant and Anti‐Inflammatory Mechanisms. Food Science & Nutrition 2026; 14(8) doi: 10.1002/fsn3.72198
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Millie Porzi, Kathryn J. Burton-Pimentel, Barbara Walther, Guy Vergères. Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management. Nutrients 2021; 13(5) doi: 10.3390/nu13051503
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Simon C Mathews, Sandy Templeton, Stephanie K Taylor, Sten Harris, Margaret Stewart, Shruti M Raja. Evaluation of a Digital Handheld Hydrogen Breath Monitor to Diagnose Lactose Malabsorption: Interventional Crossover Study. JMIR Formative Research 2021; 5(10) doi: 10.2196/33009
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Jennifer Robinson. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition. 2017;  doi: 10.21019/9781582122656.ch14
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Tiezheng Yuan, Peilong Yang, Yaru Wang, Kun Meng, Huiying Luo, Wei Zhang, Ningfeng Wu, Yunliu Fan, Bin Yao. Heterologous expression of a gene encoding a thermostable β-galactosidase from Alicyclobacillus acidocaldarius. Biotechnology Letters 2008; 30(2) doi: 10.1007/s10529-007-9551-y
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Harald Brüssow. Nutrition, population growth and disease: a short history of lactose. Environmental Microbiology 2013; 15(8) doi: 10.1111/1462-2920.12117
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Ana Zugasti Murillo. Intolerancia alimentaria. Endocrinología y Nutrición 2009; 56(5) doi: 10.1016/S1575-0922(09)71407-X
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Faruk Bozoglu. Strategies for Achieving Food Security in Central Asia. NATO Science for Peace and Security Series C: Environmental Security 2012;  doi: 10.1007/978-94-007-2502-7_9
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Nina Stourman, Jennifer Moore. Analysis of lactase in lactose intolerance supplements. Biochemistry and Molecular Biology Education 2018; 46(6) doi: 10.1002/bmb.21185
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Sara Carnevale, Assunta Vitale, Monica Razzi, Claudia Onori, Gianna Cornacchia, Ornella Grispo, Elena Corsinovi, Laura Rossl, Elena Spinetti, Martina Tosi, Fabrizia Lisso, Gianna Marchi. Non-Evidence-Based Dietary Restrictions in Hospital Nutrition and Their Impact on Malnutrition: A Narrative Review of International and National Guidelines. Dietetics 2024; 3(4) doi: 10.3390/dietetics3040039
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Gokben Hizli Sayar, Mesut Cetin. Psychobiotics: The Potential Therapeutic Promise of Microbes in Psychiatry. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 2016; 26(2) doi: 10.5455/bcp.20160531111208
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Márton Király, Ádám Tibor Barna, Nikolett Kállai-Szabó, Borbála Dalmadiné Kiss, István Antal, Krisztina Ludányi. Advances in β-Galactosidase Research: A Systematic Review from Molecular Mechanisms to Enzyme Delivery Systems. Pharmaceutics 2025; 17(12) doi: 10.3390/pharmaceutics17121538
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Ian Brown. Morson and Dawson's Gastrointestinal Pathology. 2013;  doi: 10.1002/9781118399668.ch21
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Martyna Jasielska, Urszula Grzybowska-Chlebowczyk. Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases. Gastroenterology Research and Practice 2019; 2019 doi: 10.1155/2019/2507242
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Salam A. Ibrahim, Rabin Gyawali. Milk and Dairy Products in Human Nutrition. 2013;  doi: 10.1002/9781118534168.ch12
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Smita Salunke, Catherine Tuleu. Formulating better medicines for children—Collaborate to innovate. International Journal of Pharmaceutics 2018; 536(2) doi: 10.1016/j.ijpharm.2017.08.009
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Marika M. L. Laaksonen, Vera Mikkilä, Leena Räsänen, Riikka Rontu, Terho J. Lehtimäki, Jorma S. A. Viikari, Olli T. Raitakari. Genetic lactase non-persistence, consumption of milk products and intakes of milk nutrients in Finns from childhood to young adulthood. British Journal of Nutrition 2009; 102(1) doi: 10.1017/S0007114508184677
20
Anat Yerushalmy‐Feler, Hagai Soback, Ronit Lubetzky, Amir Ben‐Tov, Margalit Dali‐Levy, Tut Galai, Shlomi Cohen. One‐third of children with lactose intolerance managed to achieve a regular diet at the three‐year follow‐up point. Acta Paediatrica 2018; 107(8) doi: 10.1111/apa.14305
21
Gabriela Zárate, Adriana Pérez Chaia. Influence of lactose and lactate on growth and β-galactosidase activity of potential probiotic Propionibacterium acidipropionici. Anaerobe 2012; 18(1) doi: 10.1016/j.anaerobe.2011.12.005
22
Tatiane A. Gomes, Luiza B. Santos, Alessandro Nogueira, Michele R. Spier. Increase in an Intracellular β-Galactosidase Biosynthesis Using L. reuteri NRRL B-14171, Inducers and Alternative Low-Cost Nitrogen Sources under Submerged Cultivation. International Journal of Food Engineering 2018; 14(3) doi: 10.1515/ijfe-2017-0333
23
Richa Salwan, Rhydum Sharma, Randhir Kaur, Vivek Sharma, Ghazala Mustafa. Pharmaceutically Relevant Microbial Enzymes. 2026;  doi: 10.1007/978-981-95-4941-2_7
24
Seoyoung Lee, Minkyoung Kang, Suyeon Lee, Jihyun Kim, Sangnam Oh. Dairy Foods as a Dietary Strategy for Muscle Health in Older Adults: An Integrative Clinical and Mechanistic Review. Journal of Dairy Science and Biotechnology 2026; 44(1) doi: 10.22424/jdsb.2026.44.1.1
25
Birgit Ahrens, Kirsten Beyer, Ulrich Wahn, Bodo Niggemann. Differential diagnosis of food‐induced symptoms. Pediatric Allergy and Immunology 2008; 19(1) doi: 10.1111/j.1399-3038.2007.00677.x
26
Paolo Aureli, Lucio Capurso, Anna Maria Castellazzi, Mario Clerici, Marcello Giovannini, Lorenzo Morelli, Andrea Poli, Fabrizio Pregliasco, Filippo Salvini, Gian Vincenzo Zuccotti. Probiotics and health: An evidence-based review. Pharmacological Research 2011; 63(5) doi: 10.1016/j.phrs.2011.02.006
27
World Gastroenterology Organisation practice guideline: Probiotics and prebiotics. Arab Journal of Gastroenterology 2009; 10(1) doi: 10.1016/j.ajg.2009.03.001
28
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Michelle Bafutto Gomes Costa, Itaciron Luz Azeredo Jr., Ricardo Duarte Marciano, Luciana Morelli Caldeira, Mauro Bafutto. Evaluation of small intestine bacterial overgrowth in patients with functional dyspepsia through H2 breath test. Arquivos de Gastroenterologia 2012; 49(4) doi: 10.1590/S0004-28032012000400009
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Elena Moroz, Simon Matoori, Jean-Christophe Leroux. Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts. Advanced Drug Delivery Reviews 2016; 101 doi: 10.1016/j.addr.2016.01.010
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G. Gasbarrini, M. Montalto, R. Assisi. The role of bacterial flora and its products in the functioning of the small intestine. Digestive and Liver Disease Supplements 2007; 1(1) doi: 10.1016/S1594-5804(08)60003-0
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M. C. E. Lomer, G. C. Parkes, J. D. Sanderson. Letters to the Editors: High frequency of MCM6 lactose intolerance genotype in Polynesian People: authors’ reply. Alimentary Pharmacology & Therapeutics 2010; 32(6) doi: 10.1111/j.1365-2036.2010.04412.x
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RENATA CRISTINA SILVA, MARCELLO G. TREVISAN, JERUSA SIMONE GARCIA. β-galactosidase Encapsulated in Carrageenan, Pectin and Carrageenan/Pectin: Comparative Study, Stability and Controlled Release. Anais da Academia Brasileira de Ciências 2020; 92(1) doi: 10.1590/0001-3765202020180609
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O. Brown-Esters, P. Mc Namara, D. Savaiano. Dietary and biological factors influencing lactose intolerance. International Dairy Journal 2012; 22(2) doi: 10.1016/j.idairyj.2011.09.010
38
Margarida C. Altas, Evgeny Kudryashov, Vitaly Buckin. Ultrasonic Monitoring of Enzyme Catalysis; Enzyme Activity in Formulations for Lactose-Intolerant Infants. Analytical Chemistry 2016; 88(9) doi: 10.1021/acs.analchem.5b04673
39
Nadia Belmatoug, Alberto Burlina, Pilar Giraldo, Chris J. Hendriksz, David J. Kuter, Eugen Mengel, Gregory M. Pastores. Gastrointestinal disturbances and their management in miglustat‐treated patients. Journal of Inherited Metabolic Disease 2011; 34(5) doi: 10.1007/s10545-011-9368-7
40
Neerupma Bhardwaj, Naama Geva-Zatorsky. Gut microbes as a therapeutic armory. Drug Discovery Today: Disease Models 2018; 28 doi: 10.1016/j.ddmod.2019.08.007
41
M Elia, J H Cummings. Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates. European Journal of Clinical Nutrition 2007; 61(S1) doi: 10.1038/sj.ejcn.1602938
42
Raíssa Aparecida Borges Batista, Dyessa Cardoso Bernardes Assunção, Fernanda Rodrigues de Oliveira Penaforte, Camila Cremonezi Japur. Lactose em alimentos industrializados: avaliação da disponibilidade da informação de quantidade. Ciência & Saúde Coletiva 2018; 23(12) doi: 10.1590/1413-812320182312.21992016
43
Grażyna Czyżak-Runowska, Jacek Antoni Wójtowski, Bogusława Łęska, Sylwia Bielińska-Nowak, Jarosław Pytlewski, Ireneusz Antkowiak, Daniel Stanisławski. Lactose Content and Selected Quality Parameters of Sheep Milk Fermented Beverages during Storage. Animals 2022; 12(22) doi: 10.3390/ani12223105
44
Arturo José Viera Oliveros, Ismael de Jesus Yepes Barreto , Natalia Andrea Skupin Rueda, Fernando García Del Risco. Caracterización de los pacientes con intolerancia a la lactosa en un centro diagnóstico de gastroenterología. Revista colombiana de Gastroenterología 2025; 40(1) doi: 10.22516/25007440.1184
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N. Pillai, K.J. Berean, R. Brkljaca, L.J. Greve, S. Kasapis, K. Kalantar-zadeh. An in-vitro upper gut simulator for assessing continuous gas production: A proof-of-concept using milk digestion. Journal of Functional Foods 2018; 47 doi: 10.1016/j.jff.2018.05.054
46
Sushma Gurumayum, Sawinder Kaur, Prasad Rasane, Jyoti Singh. Advances in Dairy Microbial Products. 2022;  doi: 10.1016/B978-0-323-85793-2.00011-4
47
Jonathan P Waud, Stephanie B Matthews, Anthony K Campbell. Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 2008; 45(1) doi: 10.1258/acb.2007.007147
48
Theresa A Nicklas, Haiyan Qu, Sheryl O Hughes, Mengying He, Sara E Wagner, Herman R Foushee, Richard M Shewchuk. Self-perceived lactose intolerance results in lower intakes of calcium and dairy foods and is associated with hypertension and diabetes in adults. The American Journal of Clinical Nutrition 2011; 94(1) doi: 10.3945/ajcn.110.009860
49
Santiago Ugidos-Rodríguez, María Cruz Matallana-González, María Cortes Sánchez-Mata. Lactose malabsorption and intolerance: a review. Food & Function 2018; 9(8) doi: 10.1039/C8FO00555A
50
Veronica Ojetti, Rossella La Mura, Maria Assunta Zocco, Paola Cesaro, Ercole De Masi, Antonietta La Mazza, Giovanni Cammarota, Giovanni Gasbarrini, Antonio Gasbarrini. Quick Test: A New Test for the Diagnosis of Duodenal Hypolactasia. Digestive Diseases and Sciences 2008; 53(6) doi: 10.1007/s10620-007-0027-7
51
Sony S Thazhath, Tongzhi Wu, Richard L Young, Michael Horowitz, Christopher K Rayner. Glucose absorption in small intestinal diseases. Expert Review of Gastroenterology & Hepatology 2014; 8(3) doi: 10.1586/17474124.2014.887439
52
Sofía Ballesta, Carmen Velasco, M.ª Victoria Borobio, Federico Argüelles, Evelio J. Perea. Yogures frescos frente a pasteurizados: estudio comparativo de sus efectos sobre los parámetros microbiológicos, inmunológicos y el bienestar gastrointestinal. Enfermedades Infecciosas y Microbiología Clínica 2008; 26(9) doi: 10.1157/13128271
53
Jennifer Robinson. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. 2015;  doi: 10.21019/9781582122250.ch14
54
Miriam Cellini, Maria Giulia Santaguida, Ilenia Gatto, Camilla Virili, Susanna Carlotta Del Duca, Nunzia Brusca, Silvia Capriello, Lucilla Gargano, Marco Centanni. Systematic Appraisal of Lactose Intolerance as Cause of Increased Need for Oral Thyroxine. The Journal of Clinical Endocrinology & Metabolism 2014; 99(8) doi: 10.1210/jc.2014-1217
55
Ewa Fidler, Jarosław Walkowiak. Nietolerancja laktozy – podstawowe zalecenia żywieniowe. Pediatria Polska 2009; 84(6) doi: 10.1016/S0031-3939(09)70090-3
56
Gabriela Aguilera, Constanza Cárcamo, Sandra Soto-Alarcón, Martin Gotteland. Improvement in Lactose Tolerance in Hypolactasic Subjects Consuming Ice Creams with High or Low Concentrations of Bifidobacterium bifidum 900791. Foods 2021; 10(10) doi: 10.3390/foods10102468
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Fabiana Castiglione, Elena Di Girolamo, Carolina Ciacci, Nicola Caporaso, Luigi Pasquale, Antonio Cozzolino, Raffaella Tortora, Anna Testa, Antonio Rispo. Lactose malabsorption: Clinical or breath test diagnosis?. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 2008; 3(6) doi: 10.1016/j.eclnm.2008.07.018
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Pascale Gerbault, Anke Liebert, Dallas M. Swallow, Mark G. Thomas. Advanced Nutrition and Dietetics in Gastroenterology. 2014;  doi: 10.1002/9781118872796.ch3.15
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Jessica M. Robinson, Traci M. Poole. APhA OTC - Gastrointestinal Disorders. 2024;  doi: 10.21019/aphaotc-gastro.intestinal-gas
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Sahar Fazal, Shah Gull, Saher Sajjad, Nazmeen Ismail, Alishba Sarwat, Nasreen Noor, Hafsa Arshad, Rao Mubashar Ali, Aqsa Qasim Zafar, Anushay Shahab, Emaan Fatima. The Role of Polyphenols and Bioactive Compounds for Combating Neurodegenerative Diseases. 2026;  doi: 10.4018/979-8-3373-4139-2.ch005
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Ki Beom Jang, Jerry M Purvis, Sung W Kim. Dose–response and functional role of whey permeate as a source of lactose and milk oligosaccharides on intestinal health and growth of nursery pigs. Journal of Animal Science 2021; 99(1) doi: 10.1093/jas/skab008
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Chad S. Cummings, Alan S. Campbell, Stefanie L. Baker, Sheiliza Carmali, Hironobu Murata, Alan J. Russell. Design of Stomach Acid-Stable and Mucin-Binding Enzyme Polymer Conjugates. Biomacromolecules 2017; 18(2) doi: 10.1021/acs.biomac.6b01723
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Vishwanath Yadav, Shreya Biswas, Arun Goyal. Industrial Microbiology and Biotechnology. 2024;  doi: 10.1007/978-981-97-1912-9_11
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G. Jan, A. Lan, P. Leverrier. Functional Dairy Products. 2007;  doi: 10.1533/9781845693107.2.165
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Eva Trifina, Dietmar Geissler, Elisabeth Zwettler, Klaus Klaushofer, Peter Mikosch. Abdominalschmerzen und Diarrhoe durch Kalziumsubstitution – Fallbericht einer Patientin mit Laktoseintoleranz. Wiener Medizinische Wochenschrift 2012; 162(5-6) doi: 10.1007/s10354-012-0064-5
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Yulia B. Monakhova, Rolf Godelmann, Claudia Andlauer, Thomas Kuballa, Dirk W. Lachenmeier. Identification of Imitation Cheese and Imitation Ice Cream Based on Vegetable Fat Using NMR Spectroscopy and Chemometrics. International Journal of Food Science 2013; 2013 doi: 10.1155/2013/367841
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Tsachi Tsadok Perets, Einav Shporn, Shoshana Aizic, Elena Kelner, Sigal Levy, Yifat Bareli, Lea Pakanaev, Yaron Niv, Ram Dickman. A Diagnostic Approach to Patients with Suspected Lactose Malabsorption. Digestive Diseases and Sciences 2014; 59(5) doi: 10.1007/s10620-013-2980-7
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Valentina Nichele, Michela Signoretto, Elena Ghedini. β-Galactosidase entrapment in silica gel matrices for a more effective treatment of lactose intolerance. Journal of Molecular Catalysis B: Enzymatic 2011; 71(1-2) doi: 10.1016/j.molcatb.2011.03.002
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Rebekah Jackowski, Traci M. Poole. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 20th Edition. 2020;  doi: 10.21019/9781582123172.ch14
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Chien-Ying Lee, Hung-Che Shih, Min-Chien Yu, Ming-Yung Lee, Ya-Lan Chang, Ya-Yun Lai, Yi-Ching Lee, Yu-Hsiang Kuan, Chun-Che Lin. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial. Chinese Journal of Integrative Medicine 2017; 23(3) doi: 10.1007/s11655-016-2531-0
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Hiroyuki Honda, Seiji Nagaoka, Yasushi Kawai, Robèr Kemperman, Jan Kok, Yukiko Yamazaki, Yoshio Tateno, Haruki Kitazawa, Tadao Saito. Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323T. The Journal of General and Applied Microbiology 2012; 58(1) doi: 10.2323/jgam.58.11
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Hongcai Zhang, Huaning Yu, Jun Mei, Yifeng Zhang, Zilong Deng. Preparation, characterization and in vitro release of β-galactosidase loaded polyelectrolyte nanoparticles. International Journal of Biological Macromolecules 2018; 115 doi: 10.1016/j.ijbiomac.2018.04.030
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Hongjun He, Xueting Zhang, Yan Sheng. Enteric-coated capsule containing β-galactosidase-loaded polylactic acid nanocapsules: enzyme stability and milk lactose hydrolysis under simulated gastrointestinal conditions. Journal of Dairy Research 2014; 81(4) doi: 10.1017/S0022029914000491
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Gisah Amaral de Carvalho, Gilberto Paz-Filho, Cleo Mesa Junior, Hans Graf. MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults. European Journal of Endocrinology 2018; 178(6) doi: 10.1530/EJE-17-0947
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Mario D. Piano, Stefania Carmagnola, Marco Ballarè, Marco Balzarini, Franco Montino, Michela Pagliarulo, Andrea Anderloni, Marco Orsello, Roberto Tari, Filomena Sforza, Luca Mogna, Giovanni Mogna. Comparison of the Kinetics of Intestinal Colonization by Associating 5 Probiotic Bacteria Assumed Either in a Microencapsulated or in a Traditional, Uncoated Form. Journal of Clinical Gastroenterology 2012; 46 doi: 10.1097/MCG.0b013e3182672796
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Geisa J. Santos, Raquel Rocha, Genoile O. Santana. Lactose intolerance: what is a correct management?. Revista da Associação Médica Brasileira 2019; 65(2) doi: 10.1590/1806-9282.65.2.270
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Sima Taheri, Morteza Khomeiri. Psychobiotics and Brain-Gut Microbiota Axis. Iranian Journal of Medical Microbiology 2019; 13(1) doi: 10.30699/ijmm.13.1.1
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Yulia B. Monakhova, Thomas Kuballa, Jenny Leitz, Claudia Andlauer, Dirk W. Lachenmeier. NMR spectroscopy as a screening tool to validate nutrition labeling of milk, lactose-free milk, and milk substitutes based on soy and grains. Dairy Science & Technology 2012; 92(2) doi: 10.1007/s13594-011-0050-5
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Pilar Giraldo, Paz Latre. Tratamiento actual de la enfermedad de Gaucher y nuevas perspectivas. Medicina Clínica 2011; 137 doi: 10.1016/S0025-7753(11)70018-5
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J. Adam Rindfleisch. Integrative Medicine. 2012;  doi: 10.1016/B978-1-4377-1793-8.00068-6
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Sarmad Ghazi Al-Shawi, Wael Ali Swadi, Alaa Abdul Hussein. Production of Probiotic (Turshi) Pickled Vegetables. Journal of Pure and Applied Microbiology 2019; 13(4) doi: 10.22207/JPAM.13.4.43
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Massimo Montalto, Antonella Gallo. Sufficient evidence that 12 g of lactose is tolerated by most adults with lactose malabsorption and intolerance but insufficient evidence on the effectiveness of therapeutical strategies tested so far. Evidence Based Medicine 2010; 15(6) doi: 10.1136/ebm1130
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Jennifer Morris, Eve Moreland, David I F Wands, Richard K Russell. Invertase is an effective and cost-efficient alternative to sacrosidase oral solution for sucrase deficiency: a cohort study. Archives of Disease in Childhood 2025; 110(9) doi: 10.1136/archdischild-2023-326793
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Rachel Gingold-Belfer, Sigal Levy, Olga Layfer, Lea Pakanaev, Yaron Niv, Ram Dickman, Tsachi Tsadok Perets. Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study. Probiotics and Antimicrobial Proteins 2020; 12(1) doi: 10.1007/s12602-018-9507-7
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