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For: Ko JKS, Lam FYL, Cheung APL. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol 2005; 11(37): 5787-5794 [PMID: 16270386 DOI: 10.3748/wjg.v11.i37.5787]
URL: https://www.wjgnet.com/1007-9327/full/v11/i37/5787.htm
Number Citing Articles
1
Fakhar Islam, Farhan Saeed, Muhammad Afzaal, Muzzamal Hussain, Entessar Al Jbawi, Muhammad Armghan Khalid, Muhammad Asif Khan. Nutritional and functional properties of Hyphaene thebaica L . flour: a critical treatise and review . International Journal of Food Properties 2022; 25(1) doi: 10.1080/10942912.2022.2078836
2
Li-Hong Qiu, Bi-Qi Zhang, Miao-Jun Lian, Xian-Ji Xie, Peng Chen. Vascular protective effects of Astragalus membranaceus and its main constituents in rats with chronic hyperhomocysteinemia. Experimental and Therapeutic Medicine 2017; 14(3) doi: 10.3892/etm.2017.4739
3
Sergey V Popov, Pavel A Markov, Ida R Nikitina, Sergey Petrishev, Vasily Smirnov, Yury S Ovodov. Preventive effect of a pectic polysaccharide of the common cranberry <i>Vaccinium oxycoccos</i> L. on acetic acid-induced colitis in mice. World Journal of Gastroenterology 2006; 12(41): 6646-6651 doi: 10.3748/wjg.v12.i41.6646
4
Mara Gagliardi, Romina Monzani, Nausicaa Clemente, Luca Fusaro, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Nissan Yissachar, Francesca Boccafoschi, Marco Corazzari. A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD). Biology 2021; 10(7) doi: 10.3390/biology10070605
5
K. Simon Yeung, Jyothirmai Gubili, Barrie R. Cassileth. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Complementary and Alternative Medicine 2011;  doi: 10.1007/978-94-007-0526-5_3
6
Shih-Yu Lee, Wei-Cheng Tsai, Jung-Chun Lin, Blerina Ahmetaj-Shala, Su-Feng Huang, Wen-Liang Chang, Tsu-Chung Chang. Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway. Scientific Reports 2017; 7(1) doi: 10.1038/s41598-017-12435-y
7
J. H. Cho, S. Zhang, I. H. Kim. Effects of Anti-diarrhoeal Herbs on Growth Performance, Nutrient Digestibility, and Meat Quality in Pigs. Asian-Australasian Journal of Animal Sciences 2012; 25(11) doi: 10.5713/ajas.2012.12339
8
E. O. Gubernatorova, A. V. Tumanov. Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation. Biochemistry (Moscow) 2016; 81(11) doi: 10.1134/S0006297916110092
9
Jing Huang, Hongyuan Chen, Chanyi Li, Wuping Liu, Wenjie Ma, Wen Rui. Screening and Identification of the Metabolites of Water Extracts of Raw and Honey-Processed Astragalus in Rat Urine Based on UHPLC/ESI-Q-TOF-MS and Multivariate Statistical Analysis. Journal of the American Society for Mass Spectrometry 2018; 29(9) doi: 10.1007/s13361-018-2003-1
10
Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang. Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus . Planta Medica 2025; 91(03) doi: 10.1055/a-2486-8873
11
Kathy Ka-Wai Auyeung, Joshua Ka-Shun Ko. Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. Investigational New Drugs 2010; 28(1) doi: 10.1007/s10637-008-9207-3
12
Amy G. W. Gong, Ran Duan, Huai Y. Wang, Xiang P. Kong, Tina T. X. Dong, Karl W. K. Tsim, Kelvin Chan. Evaluation of the Pharmaceutical Properties and Value of Astragali Radix. Medicines 2018; 5(2) doi: 10.3390/medicines5020046
13
Wei WANG, Qing-Bin LIU, Wei JING. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells. Chinese Journal of Natural Medicines 2019; 17(4) doi: 10.1016/S1875-5364(19)30029-9
14
Suzanne Mashtoub, Bang V. Hoang, Megan Vu, Kerry A. Lymn, Christine Feinle-Bisset, Gordon S. Howarth. Clinical and Structural Effects of Traditional Chinese Medicine and the Herbal Preparation, Iberogast, in a Rat Model of Ulcerative Colitis. Journal of Evidence-Based Complementary & Alternative Medicine 2014; 19(1) doi: 10.1177/2156587213503660
15
Yong Fang Gong, Shu Hou, Jia-Cheng Xu, Yan Chen, Le-Le Zhu, Ying-Ying Xu, Yu-Qing Chen, Miao-Miao Li, Li-Li Li, Jing-Jing Yang, Yan Yang. Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation. Phytomedicine 2023; 117 doi: 10.1016/j.phymed.2023.154903
16
17
Hossam S. El-Beltagi, Heba I. Mohamed, Hany N. Yousef, Eman M. Fawzi. Antioxidants in Foods and Its Applications. 2018;  doi: 10.5772/intechopen.74772
18
Ai‑Lei Wang, Yong Li, Qun Zhao, Li‑Qiao Fan. Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. Molecular Medicine Reports 2018;  doi: 10.3892/mmr.2018.8857
19
Li-Hong Qiu, Xian-Ji Xie, Bi-Qi Zhang. Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation. Biological and Pharmaceutical Bulletin 2010; 33(4) doi: 10.1248/bpb.33.641
20
Hye Min Park, Ji Yeon Lee, Min Young Kim, Chang-Ho Kang, Hyung Seo Hwang. Anti-Oxidative and Anti-Inflammatory Activities of Astragalus membranaceus Fermented by Lactiplantibacillus plantarum on LPS-Induced RAW 264.7 Cells. Fermentation 2021; 7(4) doi: 10.3390/fermentation7040252
21
Principles and Practice of Phytotherapy. 2013;  doi: 10.1016/B978-0-443-06992-5.00010-4
22
I-Chuan Sheih, Tony J. Fang, Tung-Kung Wu, Cheng-Hsiang Chang, Ru-Yin Chen. Purification and Properties of a Novel Phenolic Antioxidant from Radix astragali Fermented by Aspergillus oryzae M29. Journal of Agricultural and Food Chemistry 2011; 59(12) doi: 10.1021/jf2011547
23
24
Hai-Mei Zhao, Yan Wang, Xiao-Ying Huang, Min-Fang Huang, Rong Xu, Hai-Yang Yue, Bu-Gao Zhou, Hong-Yan Huang, Qi-Meng Sun, Duan-Yong Liu. <i>Astragalus</i> polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer&rsquo;s patches. World Journal of Gastroenterology 2016; 22(11): 3175-3185 doi: 10.3748/wjg.v22.i11.3175
25
Yong-jian Gao, Feng Zhu, Jia-ming Qian, Jia-yuan Dai. Therapeutic and immunoregulatory effect of GATA-binding protein-3/T-box expressed in T-cells ratio of astragalus polysaccharides on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Chinese Journal of Integrative Medicine 2016; 22(12) doi: 10.1007/s11655-015-2151-0
26
Weiwei Qi, Jianying Niu, Qiaojing Qin, Zhongdong Qiao, Yong Gu. Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells. Cell Stress and Chaperones 2014; 19(1) doi: 10.1007/s12192-013-0438-7
27
Abdelaziz S.A. Abuelsaad. Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response. Microbial Pathogenesis 2014; 66 doi: 10.1016/j.micpath.2013.12.005
28
Keyvan Amirshahrokhi. Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice. International Immunopharmacology 2019; 76 doi: 10.1016/j.intimp.2019.105884
29
Xiaoqing Hu, Delu Dong, Meihui Xia, Yimeng Yang, Jiabin Wang, Jing Su, Liankun Sun, Huimei Yu. Oxidative stress and antioxidant capacity: development and prospects. New Journal of Chemistry 2020; 44(27) doi: 10.1039/D0NJ02041A
30
Shuo Yuan, You Li, Jiao Li, Jia-Chen Xue, Qi Wang, Xiao-Ting Hou, Huan Meng, Ji-Xing Nan, Qing-Gao Zhang. Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.892790
31
Yiwei Gao, Xin Su, Taiqi Xue, Ning Zhang. The beneficial effects of astragaloside IV on ameliorating diabetic kidney disease. Biomedicine & Pharmacotherapy 2023; 163 doi: 10.1016/j.biopha.2023.114598
32
Heba A. Hassan, Amira Mohamed abdelhamid, Walaa Samy, Heba Osama Mohammed, Samar Mortada Mahmoud, Amal fawzy abdel mageed, Noha A.T. Abbas. Ameliorative effects of androstenediol against acetic acid-induced colitis in male wistar rats via inhibiting TLR4-mediated PI3K/Akt and NF-κB pathways through estrogen receptor β activation. International Immunopharmacology 2024; 127 doi: 10.1016/j.intimp.2023.111414
33
De-shan Liu, Yong-hong Zhou, Er-shun Liang, Wei Li, Wei-wei Lin, Fei-fei Chen, Wei Gao. Neuroprotective effects of the Chinese Yi-Qi-Bu-Shen recipe extract on injury of rat hippocampal neurons induced by hypoxia/reoxygenation. Journal of Ethnopharmacology 2013; 145(1) doi: 10.1016/j.jep.2012.10.046
34
Kathy K. Auyeung, Quan-Bin Han, Joshua K. Ko. Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers. The American Journal of Chinese Medicine 2016; 44(01) doi: 10.1142/S0192415X16500014
35
Xinhui Liu, Liwen Gao, Xi Huang, Ruyu Deng, Shanshan Wu, Yu Peng, Jiandong Lu. Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice. Frontiers in Pharmacology 2023; 14 doi: 10.3389/fphar.2023.1236820
36
Fengge Wang, Yun Zhao, Shuxiong Chen, Lu Chen, Liting Sun, Maosheng Cao, Chunjin Li, Xu Zhou. Astragaloside IV Alleviates Ammonia-Induced Apoptosis and Oxidative Stress in Bovine Mammary Epithelial Cells. International Journal of Molecular Sciences 2019; 20(3) doi: 10.3390/ijms20030600
37
Chunlan Ji, Yueming Luo, Chuan Zou, Lihua Huang, Ruimin Tian, Zhaoyu Lu. Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress. BMC Pharmacology and Toxicology 2018; 19(1) doi: 10.1186/s40360-018-0241-2
38
Hao Shan, Xueping Zheng, Min Li. The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases. International Journal of Molecular Sciences 2019; 20(8) doi: 10.3390/ijms20081904
39
Tong Chen, Ruoning Wang, Wenjiao Jiang, Huimin Wang, Ang Xu, Guo Lu, Yi Ren, Yangmei Xu, Yangyang Song, Shoulei Yong, Hui Ji, Zhanqiang Ma. Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling. Inflammation 2016; 39(1) doi: 10.1007/s10753-015-0272-4
40
KATHY KA-WAI AUYEUNG, PUI-CHING LAW, JOSHUA KA-SHUN KO. Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft. Oncology Reports 2012; 28(6) doi: 10.3892/or.2012.2056
41
Zhi-guo Zhang, Lin Wu, Ju-lei Wang, Jian-dong Yang, Jing Zhang, Jian Zhang, Li-hong Li, Yi Xia, Li-bo Yao, Huai-zhou Qin, Guo-dong Gao. Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. Molecular and Cellular Biochemistry 2012; 364(1-2) doi: 10.1007/s11010-011-1219-1
42
Negar Firouzabadi, Nahid Alimoradi, Mohammad Najafizadeh, Parvaneh Najafizadeh. Effect of escitalopram on an acetic acid‐induced ulcerative colitis model. Clinical and Experimental Pharmacology and Physiology 2021; 48(5) doi: 10.1111/1440-1681.13474
43
Yu Zhang, Wei-Na Kong, Xi-Qing Chai. Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer's disease mice. Neural Regeneration Research 2018; 13(4) doi: 10.4103/1673-5374.230302
44
Lingling Wang, Feng Xiong, Lucun Yang, Yuanming Xiao, Guoying Zhou. A Seasonal Change of Active Ingredients and Mineral Elements in Root of Astragalus membranaceus in the Qinghai-Tibet Plateau. Biological Trace Element Research 2021; 199(10) doi: 10.1007/s12011-020-02486-0
45
Yuxi Liang, Qiuyan Zhang, Linjing Zhang, Rufeng Wang, Xiaoying Xu, Xiuhua Hu. Astragalus Membranaceus Treatment Protects Raw264.7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2019; 2019 doi: 10.1155/2019/2971604
46
Qiuping Xiao, Lin Luo, Xiyan Zhu, Yuhao Yan, Shanshan Li, Liling Chen, Xiaomin Wang, Jie Zhang, Duanyong Liu, Ronghua Liu, Youbao Zhong. Formononetin alleviates ulcerative colitis via reshaping the balance of M1/M2 macrophage polarization in a gut microbiota-dependent manner. Phytomedicine 2024; 135 doi: 10.1016/j.phymed.2024.156153
47
Sandeep Vasant More, Sushruta Koppula, In-Su Kim, Hemant Kumar, Byung-Wook Kim, Dong-Kug Choi. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules 2012; 17(6) doi: 10.3390/molecules17066728
48
Nidhi Goyal, Ajay Rana, Abhilasha Ahlawat, Krishna Reddy V. Bijjem, Puneet Kumar. Animal models of inflammatory bowel disease: a review. Inflammopharmacology 2014; 22(4) doi: 10.1007/s10787-014-0207-y
49
Chunkun Yang, Qingquan Pan, Kui Ji, Zhuang Tian, Hongyuan Zhou, Shuanghong Li, Chuanchao Luo, Jun Li. Review on the protective mechanism of astragaloside IV against cardiovascular diseases. Frontiers in Pharmacology 2023; 14 doi: 10.3389/fphar.2023.1187910
50
Wei Zhang, Anlan Hu, Juan Wang, Yudian Wang, Xiaoyong Yu. Use of Chinese Herbal Medicine to Inhibit Podocyte Damage as Therapeutic Strategy for Membranous Nephropathy. Integrative Medicine in Nephrology and Andrology 2023; 10(3) doi: 10.1097/IMNA-D-23-00004
51
LEI QIU, GUOJIAN YIN, LI CHENG, YUTING FAN, WENQIN XIAO, GE YU, MIAO XING, RONGRONG JIA, RUIQING SUN, XIUYING MA, GUOYONG HU, XINGPENG WANG, MAOCHUN TANG, YAN ZHAO. Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB. International Journal of Molecular Medicine 2015; 35(3) doi: 10.3892/ijmm.2015.2070
52
Youbao Zhong, Wenjun Liu, Yanxia Xiong, Yingmeng Li, Qi Wan, Wen Zhou, Haimei Zhao, Qiuping Xiao, Duanyong Liu. Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells. Phytomedicine 2022; 104 doi: 10.1016/j.phymed.2022.154287
53
Jingjing Wang, Rui Zhang, Chenguang Wu, Lifan Wang, Peng Liu, Ping Li. Exploring potential targets for natural product therapy of DN: the role of SUMOylation. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1432724
54
Dániel Érces, Gabriella Varga, Borbála Fazekas, Tamás Kovács, Tünde Tőkés, László Tiszlavicz, Ferenc Fülöp, László Vécsei, Mihály Boros, József Kaszaki. N-methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats. European Journal of Pharmacology 2012; 691(1-3) doi: 10.1016/j.ejphar.2012.06.044
55
Om Prakash, Bikash Medhi, Uma Nahar Saikia, Promila Pandhi. Effect of Different Doses of Thalidomide in Experimentally Induced Inflammatory Bowel Disease in Rats. Basic & Clinical Pharmacology & Toxicology 2008; 103(1) doi: 10.1111/j.1742-7843.2008.00240.x
56
Rongfa Chen, Hua Shao, Shiqing Lin, Jin-Jun Zhang, Kang-Qing Xu. Treatment with Astragalus membranaceus Produces Antioxidative Effects and Attenuates Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in Rats. The American Journal of Chinese Medicine 2011; 39(05) doi: 10.1142/S0192415X11009275
57
Asie Shojaii, Manijeh Motevalian, Nazanin Rahnama. Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models. Journal of Basic and Clinical Physiology and Pharmacology 2015; 26(4) doi: 10.1515/jbcpp-2014-0092
58
Min Hou, Yufang Leng, Yajing Shi, Zhiguo Tan, Xiangzhen Min. Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence. The American Journal of Chinese Medicine 2023; 51(06) doi: 10.1142/S0192415X23500684
59
Louise Langmead, David S. Rampton. Inflammatory Bowel Disease. 2010;  doi: 10.1002/9781444318418.ch48
60
Zeena Hadi Mageed, Majid K. Abbas, Ahmed Raji. Anti-Inflammatory Effect of Atorvastatin on Colitis Induced in Male Mice. Medical Journal of Babylon 2024; 21(2) doi: 10.4103/MJBL.MJBL_3_23
61
Yixin He, Min Du, Yan Gao, Hongshuai Liu, Hongwei Wang, Xiaojun Wu, Zhengtao Wang, Sven G. Meuth. Astragaloside IV Attenuates Experimental Autoimmune Encephalomyelitis of Mice by Counteracting Oxidative Stress at Multiple Levels. PLoS ONE 2013; 8(10) doi: 10.1371/journal.pone.0076495
62
Joshua Ka-Shun Ko, Cecilia Wai-Shan Chik. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine 2009; 47(2) doi: 10.1016/j.cyto.2009.05.014
63
Prasad Byrav D.S., Bikash Medhi, Ajay Prakash, Amitava Chakrabarti, Kim Vaiphei, Krishan L. Khanduja. Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. Pharmacological Reports 2013; 65(4) doi: 10.1016/S1734-1140(13)71076-4
64
YAO LU, SU LI, HENGFANG WU, ZHIPING BIAN, JINDAN XU, CHUNRONG GU, XIANGJIAN CHEN, DI YANG. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells. International Journal of Molecular Medicine 2015; 36(5) doi: 10.3892/ijmm.2015.2345
65
Xiunan Wei, Xiaohui Leng, Junwei Liang, Jiahui Liu, Lili Chi, Hualiang Deng, Dajuan Sun. Pharmacological potential of natural medicine Astragali Radix in treating intestinal diseases. Biomedicine & Pharmacotherapy 2024; 180 doi: 10.1016/j.biopha.2024.117580
66
Yan Yang, Sen Yang, Minzhu Chen, Xiaoxiang Zhang, Yuhong Zou, Xuejun Zhang. Compound Astragalus and Salvia miltiorrhiza Extract exerts anti-fibrosis by mediating TGF-β/Smad signaling in myofibroblasts. Journal of Ethnopharmacology 2008; 118(2) doi: 10.1016/j.jep.2008.04.012
67
Rong Zheng, Yueyi Deng, Yiping Chen, Junming Fan, Minghua Zhang, Yifei Zhong, Rong Zhu, Lin Wang. Astragaloside IV Attenuates Complement Membranous Attack Complex Induced Podocyte Injury Through the MAPK Pathway. Phytotherapy Research 2012; 26(6) doi: 10.1002/ptr.3656
68
Sulan Yu, Xinyao Zhou, Ruihua Liu, Xiaoyu Xu, Danbao Ma, Yun Feng, Xiang Lin. Immunomodulatory effects of Yu-Ping-Feng formula on primary Sjögren syndrome: interrogating the T-cell response. Journal of Leukocyte Biology 2025; 117(2) doi: 10.1093/jleuko/qiae155
69
Bikash Medhi, Ajay Prakash, Pramod K Avti, Amitava Chakrabarti, Krishan L Khanduja. Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-α in a rat model. Journal of Pharmacy and Pharmacology 2009; 61(10) doi: 10.1211/jpp.61.10.0013
70
Wei-Na Yu, Li-Feng Sun, Hua Yang. Inhibitory Effects of Astragaloside IV on Bleomycin-Induced Pulmonary Fibrosis in Rats Via Attenuation of Oxidative Stress and Inflammation. Inflammation 2016; 39(5) doi: 10.1007/s10753-016-0420-5