Surgery with adjuvant or neoadjuvant treatment vs surgery alone for resectable pancreatic cancer: A network meta-analysis

Table 1 Study characteristics of included studies

Study	Arms	Number	Period	Country	Schedule
Casadei et al[20], 2015	NCRT + S	18	2007-2014	Italy	2 cycles of gemcitabine 1000 mg/m2 on days 1 and 8 every 21 d, then 45 Gy radiation with gemcitabine 50 mg/m2 twice weekly for 6 wk
	Surgery	20
Golcher et al[21], 2015	NCRT + S	33	2003-2009	Germany, Switzerland	8 Gy to 55.8 Gy (tumor) or 50.4 Gy (regional lymph nodes) radiation with gemcitabine 300 mg/m2 and cisplatin 30 mg/m2 on days 1, 8, 22, and 29
	Surgery	33
Oettle et al[22,26], 2007, 2013	S + ACT	179	1998-2004	Germany, Austria	3 cycles of gemcitabine 1000 mg/m2 on days 1, 8, and 15 every 4 wk
	Surgery	175
Kosuge et al[27], 2006	S + ACT	45	1992-2000	Japan	2 courses of cisplatin 80 mg/m2 on the first day; 5-fluorouracil 500 mg/m2 daily for the first 5 d
	Surgery	44
Ueno et al[24], 2009	S + ACT	58	2002-2005	Japan	3 cycles of gemcitabine 1000 mg/m2 on days 1, 8, and 15 every 4 wk
	Surgery	60
Bakkevold et al[31], 1993	S + ACT	30	1984-1987	Norway	6 cycles of 5-fluorouracil 500 mg/m2, doxorubicin 40 mg/m2, and mitomycin C 6 mg/m2 once every 3 wk
	Surgery	31
Smeenk et al[8], 2007 Klinkenbijl et al[30], 1999	S + ACDT	110	1987-1995	Europe	2 courses of 20 Gy radiotherapy (2 Gy/d, 5 d/wk at weeks 1-2 and 5-6) and 25 mg/kg 5- fluorouracil daily for 5 d
	Surgery	108
Kalser et al[32], 1985	S + ACDT	21	1974-1982	USA	2 courses of 20 Gy (5 d a week) radiotherapy and 500 mg/m2 fluorouracil daily for 3 d
	Surgery	22
Van Laethem et al[23], 2010	S + ACDT	45	2004-2007	France	2 cycles of gemcitabine 1000 mg/m2 weekly for 3 wk; followed by 50.4 Gy radiotherapy and 300 mg/m2 gemcitabine weekly for two weeks
	S + ACT	45			4 cycles of gemcitabine 1000 mg/m2 weekly for 3 wk
Neoptolemos et al[25,28,29], 2001, 2004, 2009 (ESPAC-1)	S + ACDT	73	1994-2000	Europe	2 courses of 20 Gy radiotherapy and 500 mg/m2 fluorouracil on days 1-3
	S + ACT	75			6 courses of fluorouracil 425 mg/m2 and folinic acid 20 mg/m2 daily for 5 d
	S + ACT + ACDT	72			2 courses of 20 Gy radiotherapy and 500 mg/m2 fluorouracil on days 1-3; then 6 courses of fluorouracil 425 mg/m2 and folinic acid 20 mg/m2 daily for 5 d
	Surgery	69
ESPAC-1 plus	S + ACDT	33	1994-2000	Europe	2 courses of 20 Gy radiotherapy and 500 mg/m2 fluorouracil on days 1–3
	Surgery	36
	S + ACT	97			6 courses of fluorouracil 425 mg/m2 and folinic acid 20 mg/m2 daily for 5 d
	Surgery	95
ESPAC-3 (V1)	S + ACT	61	1994-2000	Europe	6 courses of fluorouracil 425 mg/m2 and folinic acid 20 mg/m2 daily for 5 d
	Surgery	61

NCRT + S: Neoadjuvant chemoradiotherapy with surgery; S + ACT: Surgery with adjuvant chemotherapy; S + ACRT: Surgery with adjuvant chemoradiotherapy.