Liquid biopsy in hepatobiliary and pancreatic cancers: A paradigm shift in early detection, prognostic stratification, and perioperative monitoring

Table 5 Role of liquid biopsy in intra-operative period

No.	Title of study	Ref.	Conclusion of study
1	Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection	Wang et al[66], 2022	Shows that simultaneous mutation and methylation analysis of cfDNA improves HCC detection
2	Liquid biopsy for monitoring minimal residual disease in localized and locally-advanced non-small cell lung cancer after radical-intent treatment	Aguilar et al[6], 2024	Evaluates liquid biopsy for detecting minimal residual disease in lung cancer, supporting its role in post-treatment monitoring
3	Current role and future perspectives of immunotherapy and circulating factors in treatment of biliary tract cancers	Conci et al[68], 2023	Reviews the role of immunotherapy and circulating biomarkers in the treatment of biliary tract cancers

cfDNA: Cell free DNA; HCC: Hepatocellular carcinoma.