Karbalaei M, Sahebkar A, Keikha M. Helicobacter pylori infection and susceptibility to cardiac syndrome X: A systematic review and meta-analysis. World J Meta-Anal 2021; 9(2): 208-219 [DOI: 10.13105/wjma.v9.i2.208]
Corresponding Author of This Article
Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Park Square, Mashhad 9177948974, Iran. masoud.keykha90@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mohsen Karbalaei, Department of Microbiology and Virology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 43317803, Iran
Amirhossein Sahebkar, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Amirhossein Sahebkar, Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Masoud Keikha, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948974, Iran
Author contributions: Keikha M and Sahebkar A equally contributed to the conception and design of the study; Karbalaei M and Keikha M conducted the literature review and analyses; All authors equally contributed to drafting and critical revision and editing of the manuscript, and approved the final version.
Conflict-of-interest statement: No potential conflicts of interest.
PRISMA 2009 Checklist statement: The manuscript was revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Park Square, Mashhad 9177948974, Iran. masoud.keykha90@gmail.com
Received: December 30, 2020 Peer-review started: December 30, 2020 First decision: February 28, 2021 Revised: March 3, 2021 Accepted: April 23, 2021 Article in press: April 23, 2021 Published online: April 28, 2021
Core Tip
Core Tip: According to various studies, persistent colonization and chronic inflammation caused by Helicobacter pylori (H. pylori) infection can lead to systemic disorders outside the gastrointestinal tract. Recently, the role of H. pylori in cardiac syndrome X (CSX) has garnered attention. Nevertheless, the mechanism of this syndrome is not fully understood, and it remains controversial. Data from 11 studies were evaluated to assess the association between H. pylori infection and CSX. The results showed that there is a positive association between infection with this bacterium and the development of CSX. It seems that H. pylori increase the risk of CSX through dysregulation of the immune response and alternating epigenetic events. Statistical analyses showed that the presence of CSX was not dependent on cagA status. Several limitations such as small sample size, heterogeneity, and publication bias indicate that confirmation of the present results by further prospective investigation is necessary.
