Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Jun 28, 2022; 10(3): 162-176
Published online Jun 28, 2022. doi: 10.13105/wjma.v10.i3.162
Is cellular therapy beneficial in management of rotator cuff tears? Meta-analysis of comparative clinical studies
Sathish Muthu, Cheruku Mogulesh, Vibhu Krishnan Viswanathan, Naveen Jeyaraman, Satvik N Pai, Madhan Jeyaraman, Manish Khanna
Sathish Muthu, Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624001, Tamil Nadu, India
Sathish Muthu, Madhan Jeyaraman, Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201306, Uttar Pradesh, India
Sathish Muthu, Cheruku Mogulesh, Naveen Jeyaraman, Madhan Jeyaraman, Manish Khanna, Indian Stem Cell Study Group Association, Lucknow 226010, Uttar Pradesh, India
Cheruku Mogulesh, Naveen Jeyaraman, Department of Orthopaedic Rheuamtology, Dr Ram Manohar Lohiya National Law University, Lucknow 226010, Uttar Pradesh, India
Vibhu Krishnan Viswanathan, Department of MSK Oncology, University of Calgary, Alberta AB T2N 1N4, Alberta, Canada
Naveen Jeyaraman, Department of Orthopaedics, Atlas Hospitals (The Tamil Nadu Dr MGR Medical University), Tiruchirappalli 620002, Tamil Nadu, India
Satvik N Pai, Department of Orthopaedics, Sri Ramachandra Medical College and Research Institute, Chennai 600116, Tamil Nadu, India
Madhan Jeyaraman, Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600095, Tamil Nadu, India
Madhan Jeyaraman, Manish Khanna, Department of Orthopaedics, South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, United States
Manish Khanna, Department of Orthopaedics, Autonomous State Medical College, Ayodhya 224135, Uttar Pradesh, India
Author contributions: Muthu S conducted the research along with Viswanathan VK; Jeyaraman N, Patel K, Chellamuthu G, Jeyaraman M, and Khanna M helped in the conduction of the study; all authors have read and approved the final manuscript.
Conflict-of-interest statement: None of the authors have a conflict of interest over the subject presented.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Madhan Jeyaraman, MS, Assistant Professor, Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Adayalampattu, Chennai 600095, Tamil Nadu, India. madhanjeyaraman@gmail.com
Received: February 4, 2022
Peer-review started: February 4, 2022
First decision: April 19, 2022
Revised: May 2, 2022
Accepted: June 22, 2022
Article in press: June 22, 2022
Published online: June 28, 2022
Core Tip

Core Tip: Biological augmentation of rotator cuff tears with mesenchymal stromal cell-based cellular therapy significantly reduces the pain severity and improves the functional outcome at 3 and 6 mo based on our critical review of clinical studies on the subject. Moreover, we noted enhanced radiological tendon healing, and mitigated retear rates at both short- and long-term follow-ups. We have also established the safety of using cellular therapy in patients presenting with rotator cuff tears.