Cheng DJ, Zheng XY, Tang SF. Large cutaneous epithelioid angiomatous nodules in a patient with nephrotic syndrome: A case report. World J Clin Cases 2020; 8(3): 600-605 [PMID: 32110672 DOI: 10.12998/wjcc.v8.i3.600]
Corresponding Author of This Article
Shui-Fu Tang, MD, PhD, Academic Fellow, Professor, Division of Nephrology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 16, Ji Chang Road, Baiyun District, Guangzhou 510405, Guangdong Province, China. tsf0838@126.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2020; 8(3): 600-605 Published online Feb 6, 2020. doi: 10.12998/wjcc.v8.i3.600
Large cutaneous epithelioid angiomatous nodules in a patient with nephrotic syndrome: A case report
De-Jin Cheng, Xiang-Yue Zheng, Shui-Fu Tang
De-Jin Cheng, First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Xiang-Yue Zheng, Division of Ophthalmology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Shui-Fu Tang, Division of Nephrology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Author contributions: Tang SF decided the patient’s treatment plan; Cheng DJ wrote the paper; Zheng XY collected the clinical data.
Informed consent statement: The patient has read and signed the Informed Consent for publication of this report.
Conflict-of-interest statement: No conflicts of interest.
CARE Checklist (2016) statement: The authors wrote the manuscript according to the requirements of the CARE Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shui-Fu Tang, MD, PhD, Academic Fellow, Professor, Division of Nephrology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 16, Ji Chang Road, Baiyun District, Guangzhou 510405, Guangdong Province, China. tsf0838@126.com
Received: November 25, 2019 Peer-review started: November 25, 2019 First decision: December 11, 2019 Revised: December 24, 2019 Accepted: January 8, 2020 Article in press: January 8, 2020 Published online: February 6, 2020
Abstract
BACKGROUND
Cutaneous epithelioid angiomatous nodules (CEAN) are rare, benign, vascular lesions characterized by benign proliferation of endothelial cells with prominent epithelioid features, which can be easily confused with benign and malignant vascular tumors. However, the etiology of CEAN remains unclear, and no association with infection, trauma, or immunosuppression has been described. This case study indicated that CEAN is closely related to the patient’s impaired immune status and may be induced by cyclosporine.
CASE SUMMARY
A 19-year-old boy with nephrotic syndrome (NS) developed large CEAN on the left foot during treatment for NS. He had repeated relapses of edema in the past 6 years and different types of immunosuppressants were administered including methylprednisolone, mycophenolate mofetil, tacrolimus and cyclosporine; the dosages of these drugs were frequently adjusted. The patient had been receiving cyclosporine and methylprednisolone for 7 mo before he developed CEAN. Cyclosporine was discontinued due to its side effects on skin. After cessation of cyclosporine and 16 mo follow-up, the nodules gradually disappeared without any other treatment for the CEAN.
CONCLUSION
Impaired immune status is proposed to be a risk factor for CEAN, which may be induced by cyclosporine.
Core tip: As reported in this article, impaired immune status is proposed to be a risk factor for cutaneous epithelioid angiomatous, which may be induced by cyclosporine.
