Review
Copyright ©The Author(s) 2015.
World J Pharmacol. Jun 9, 2015; 4(2): 193-209
Published online Jun 9, 2015. doi: 10.5497/wjp.v4.i2.193
Table 1 Pharmacokinetics and ageing
Absorption↓ amount of saliva
↑ gastric pH
↓ gastric acid secretion
↑ gastric emptying time
↓ gastric surface area
↓ gastrointestinal motility
↓ active transport mechanisms
Distribution↓ cardiac output
↑ peripheral vascular resistance
↓ renal blood flow
↓ hepatic blood flow
↓ body water
↑ body fat tissue
↓ serum albumin levels
↑ for lipid soluble and decrease for water soluble drugs
Metabolic↓ microsomal hepatic oxidation
↓ clearance
↑ steady state levels
↑ half lives
↑ levels of active metabolites
↓ first pass metabolism due to reduced ↓ blood flow
Excretion↓ in renal perfusion
↓ in renal size
↓ in glomerular filtration rate
↓ tubular secretion
↓ in tubular reabsorption