Epigenetics in the etiology and management of infertility

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Med Genet. Oct 27, 2022; 10(2): 7-21
Published online Oct 27, 2022. doi: 10.5496/wjmg.v10.i2.7

Table 3 Selected epigenetic drugs and their activities

Epigenetic drug	Target	Effect	Ref.
Choline	HDAC3	Increases DNA methylation	[15]
Betaine	HDAC3	Increases DNA methylation	[15]
Bobcat339	TETs and TET2	Increases DNA methylation	[15]
C35	TET	Increases DNA methylation	[91]
Zebularine	DNMTs	Reduces hypermethylation	[92]
Disulfiran	DNMTs	Reduces hypermethylation	[92]
Decitabine	DNMTs	Reduces hypermethylation	[92]
Azacitidine	DNMTs	Reduces hypermethylation	[92]
Chaeton	DNMTs	Reduces hypermethylation	[92]
RGFP966	HDAC3	Inhibits histone modification	[95,96]
RG108	Anti-miRNA	Reduces gene expression	[98,99]

DNMTs: DNA methyltransferase; HDAC: Histone deacetylases; TETs: Ten-eleven translocation; miRNA: MicroRNA.

Citation: Yahaya TO, Bashar DM, Oladele EO, Umar J, Anyebe D, Izuafa A. Epigenetics in the etiology and management of infertility. World J Med Genet 2022; 10(2): 7-21
URL: https://www.wjgnet.com/2220-3184/full/v10/i2/7.htm
DOI: https://dx.doi.org/10.5496/wjmg.v10.i2.7

Yahaya TO, Bashar DM, Oladele EO, Umar J, Anyebe D, Izuafa A. Epigenetics in the etiology and management of infertility. World J Med Genet 2022; 10(2): 7-21 [DOI: 10.5496/wjmg.v10.i2.7]

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