Epigenetics in the etiology and management of infertility

Table 3 Selected epigenetic drugs and their activities

Epigenetic drug	Target	Effect	Ref.
Choline	HDAC3	Increases DNA methylation	[15]
Betaine	HDAC3	Increases DNA methylation	[15]
Bobcat339	TETs and TET2	Increases DNA methylation	[15]
C35	TET	Increases DNA methylation	[91]
Zebularine	DNMTs	Reduces hypermethylation	[92]
Disulfiran	DNMTs	Reduces hypermethylation	[92]
Decitabine	DNMTs	Reduces hypermethylation	[92]
Azacitidine	DNMTs	Reduces hypermethylation	[92]
Chaeton	DNMTs	Reduces hypermethylation	[92]
RGFP966	HDAC3	Inhibits histone modification	[95,96]
RG108	Anti-miRNA	Reduces gene expression	[98,99]

DNMTs: DNA methyltransferase; HDAC: Histone deacetylases; TETs: Ten-eleven translocation; miRNA: MicroRNA.