Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

Table 7 Rates of intraoperative and postoperative complications in cohorts matched for each outcome

Characteristic	Neoadjuvant patients n = 234 (50.00%)3	Surgery-only patients n = 234 (50.00%)3	Odds ratio (95%CI)	P-value1
30-d mortality (%)	19 (8.12)	12 (5.13)	1.63 (0.77-3.45)	0.197
Overall morbidity (%)	63 (26.92)	42 (17.95)	1.68 (1.08-2.62)	0.0211
Return to OR	22 (9.40)	7 (2.99)	3.37 (1.41-8.04)	0.0061
Cardiac complication	10 (4.27)	4 (1.71)	2.57 (0.79-8.30)	0.116
Shock/sepsis	11 (4.70)	3 (1.28)	3.80 (1.05-13.80)	0.0431
Unplanned intubation	27 (11.54)	17 (7.26)	1.66 (0.88-3.14)	0.116
Bleeding transfusion	28 (11.97)	13 (5.56)	2.31 (1.17-4.58)	0.0161
Serious morbidity (%)	44 (18.80)	28 (11.97)	1.70 (1.02-2.85)	0.0421
Length of stay (d)2
Predicted difference in means	--	--	-1.02 (-1.54 to -0.50)	< 0.0011
Prolonged length of stay (%)	44 (18.80)	63 (26.92)	0.63 (0.41-0.97)	0.0371
Operative time (min)2
Predicted difference in means	--	--	29.0 (26.5-31.6)	< 0.0011
Prolonged operative time (%)	90 (38.46)	62 (26.50)	1.73 (1.17-2.57)	0.0061

¹Two-sided P values < 0.05 considered statistically significant;

²Modified Park test found Poisson most appropriate distribution to account for non-normality of the count data; average marginal effects used to calculate predicted difference in the mean;

³Separate cohorts were generated for each outcome using propensity-score-based 1:1 nearest-neighbor matching without replacement, accounting for baseline differences in demographic and clinical characteristics. While all cohorts had an equal distribution of matched neoadjuvant and surgery-only patients (n = 234) by design, no two cohorts necessarily contain the same patients in order to account for cohorts appropriately weighted to each outcome. OR: Operating room.