Monogenic inflammatory bowel disease: An unfolding enigma

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Sep 9, 2025 (publication date) through Jun 16, 2025

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Pediatr. Sep 9, 2025; 14(3): 107165
Published online Sep 9, 2025. doi: 10.5409/wjcp.v14.i3.107165

Table 3 Clinical scenarios to suspect monogenic inflammatory bowel disease

Conditions to suspect monogenic IBD
Young age matters most
Young age (onset < 2 years/< 6 years with red flags)
Multiple family members with IBD with suspected monogenic disorder and consanguinity
Autoimmunity
Thriving failure
Treatment with conventional medication fails
Endocrine concerns
Recurrent infections or unexplained fever
Severe perianal disease
Macrophage activation syndrome and hemophagocytic lymphohistiocytosis
Obstruction and atresia of the intestine
Skin lesions, dental and hair abnormalities
Tumors

IBD: Inflammatory bowel disease.

Citation: Ghosh U, Samanta A. Monogenic inflammatory bowel disease: An unfolding enigma. World J Clin Pediatr 2025; 14(3): 107165
URL: https://www.wjgnet.com/2219-2808/full/v14/i3/107165.htm
DOI: https://dx.doi.org/10.5409/wjcp.v14.i3.107165