Analysis of fatal outcomes of patients with mucopolysaccharidosis type II according to the Russian mucopolysaccharidosis registry

Table 5 The predictors of the fatal outcome in mucopolysaccharidosis type II patients according to Cox-regression analysis

Predictors	SE	HR (95%CI)	P value
Psychomotor development delay (up to 1 year)	0.26	3.4 (1.2; 9.3)	0.019
Delayed mental and speech development (1-3 years)	0.33	5.7 (1.8; 17.9)	0.003
Hydrocephalus	0.30	3.3 (1.03; 10.4)	0.044
Epilepsia	0.28	4.4 (1.5; 12.8)	0.008
Swallow disorders	0.29	5.1 (1.6; 16.7)	0.006
Impossible walking at age < 12 years	0.40	4.9 (1.01; 23.3)	0.049
Impossible walking at the age > 12 years	0.31	9.4 (2.8; 31.3)	0.0003
Respiratory disorders	0.38	5.7 (1.3; 25.6)	0.023
Tracheostomia	0.33	4.7 (1.3; 16.7)	0.022
Neuronopathic form	0.27	4.1 (1.4; 11.9)	0.01

SE: Standard error; HR: Hazard ratio.