Comparative analysis on the efficacy of antenatal corticosteroids in preterm newborns in a Kazakhstani Tertiary Care Hospital setting

Table 1 Obstetric and gynecological history of mothers of preterm newborns based on the extent of antenatal steroid prophylaxis, n (%)

Parameters	Obstetric and gynecological history of mothers of preterm newborns based on the extent of antenatal steroid prophylaxis				P value
	Complete, n = 71	Absent, n = 49	Incomplete, n = 32	Total, n = 152
Multiple pregnancy					Р = 0.056, α = 0.0167
Yes	12 (57.1)	2 (9.5)	7 (33.3)	21 (100)
No	59 (45.0)	47 (35.9)	25 (19.1)	131 (100)
Abortion					χ² = 3.73, P = 0.155
Yes	30 (52.6)	13 (22.8)	14 (24.6)	57 (100)
No	41 (43.2)	36 (37.9)	18 (18.9)	95 (100)
Intrauterine infections					Р = 0.623, α = 0.0167
Yes	1 (25.0)	3 (75.0)	0 (0.0)	4 (100)
No	70 (47.3)	46 (31.1)	32 (21.6)	148 (100)
IVF					Р = 0.0012, α = 0.0167; Group 1 – Group 2: P = 1.000; Group 1 – Group 3: Р = 1.000; Group 2 – Group 3: Р = 1.000
Yes	2 (66.7)	0 (0.0)	1 (33.3)	3 (100)
No	69 (46.3)	49 (32.9)	31 (20.8)	149 (100)
Gestational hypertension					χ² = 0.906, P = 0.636
Yes	15 (53.6)	7 (25.0)	6 (21.4)	28 (100)
No	56 (45.2)	42 (33.9)	26 (21.0)	124 (100)
Gestational diabetes					Р = 1.0, α = 0.0167
Yes	2 (25.0)	1 (12.5)	5 (62.5)	8 (100)
No	69 (47.9)	48 (33.3)	27 (18.8)	144 (100)
Gestational thrombocytopenia					Р = 0.056, α = 0.0167
Yes	11 (55.0)	2 (10.0)	7 (35.0)	20 (100)
No	60 (45.5)	47 (35.6)	25 (18.9)	132 (100)
Fetal growth restriction					Р = 0.203, α = 0.0167
Yes	3 (27.3)	6 (54.5)	2 (18.2)	11 (100)
No	68 (48.2)	43 (30.5)	30 (21.3)	141 (100)
Preeclampsia					χ² = 4.317, P = 0.115
Yes	17 (51.5)	6 (18.2)	10 (30.3)	33 (100)
No	54 (45.4)	43 (36.1)	22 (18.5)	119 (100)
Eclampsia					Р = 0.408, α = 0.0167
Yes	0 (0.0)	1 (100.0)	0 (0.0)	1 (100)
No	71 (47.0)	48 (31.8)	32 (21.2)	151 (100)
HELLP syndrome					Р = 1.000, α = 0.0167
Yes	0 (0.0)	0 (0.0)	1 (100.0)	1 (100.0)
No	71 (47.0)	49 (32.5)	31 (20.5)	151 (100.0)
Bleeding					Р = 0.484, α = 0.0167
Yes	4 (36.4)	5 (45.5)	2 (18.2)	11 (100)
No	67 (47.5)	44 (31.2)	30 (21.3)	141 (100)
Threatening fetal condition					χ² = 3.014, P = 0.222
Yes	10 (34.5)	10 (34.5)	9 (31.0)	29 (100)
No	61 (49.6)	39 (31.7)	23 (18.7)	123 (100)
Polyhydramnios					Р = 0.647, α = 0.0167
Yes	4 (50.0)	1 (12.5)	3 (37.5)	8 (100)
No	67 (46.5)	48 (33.3)	29 (20.1)	144 (100)
Oligohydramnios					χ² = 0.339, P = 0.844
Yes	19 (47.5)	14 (35.0)	7 (17.5)	40 (100)
No	52 (46.4)	35 (31.3)	25 (22.3)	112 (100)
PPROM					Р = 0.023, α = 0.0167
Yes	4 (28.6)	9 (64.3)	1 (7.1)	14 (100)
No	67 (48.6)	40 (29.0)	31 (22.5)	138 (100)
Atonic period					χ² = 9.304, Р = 0.0095; Group 1 – Group 2: P = 0.006 (α < 0.0167); Group 1 – Group 3: P = 0.426; Group 2 – Group 3: P = 0.380
Yes	39 (59.1)	15 (22.7)	12 (18.2)	66 (100)
No	32 (37.2)	34 (39.5)	20 (23.3)	86 (100)
Uterine scar					Р = 0.019, α = 0.0167
Yes	13 (41.9)	15 (48.4)	3 (9.7)	31 (100)
No	58 (47.9)	34 (28.1)	29 (24.0)	121 (100)
Cesarean section					χ² = 0.658, P = 0.720
Yes	49 (45.0)	36 (33.0)	24 (22.0)	109 (100)
No	22 (51.2)	13 (30.2)	8 (18.6)	43 (100)
Adhesive process					Р = 0.154, α = 0.0167
Yes	3 (100)	0 (0.0)	0 (0.0)	3 (100)
No	68 (45.6)	49 (32.9)	32 (21.5)	149 (100)
Chorioamnionitis					Р = 0.794, α = 0.0167
Yes	5 (55.6)	2 (22.2)	2 (22.2)	9 (100)
No	66 (46.2)	47 (32.9)	30 (21.0)	143 (100)
Bleeding					Р = 0.642, α = 0.0167
Yes	4 (36.4)	5 (45.5)	2 (18.2)	11 (100)
No	67 (47.5)	44 (31.2)	30 (21.3)	141 (100)
Induction with misoprostol					Р = 0.624, α = 0.0167
Yes	7 (58.3)	3 (25.0)	2 (16.7)	12 (100)
No	64 (45.7)	46 (32.9)	30 (21.4)	140 (100)
Recurrent pregnancy loss					0.743
Yes	7 (53.8)	3 (23.1)	3 (23.1)	13 (100)
No	64 (46.0)	46 (33.1)	29 (20.9)	139 (100)

IVF: In vitro fertilization; PPROM: Preterm premature rupture of membranes.