Incidence of gastro-esophageal reflux disease in mechanically ventilated full-term Egyptian neonates by detection of pepsin in endotracheal aspirate

Table 6 Correlation of pepsin in sample A, B and C with other studied parameters among the studied cases

	Sample A ETA pepsin (ng/mL)		Sample B ETA pepsin (ng/mL)		Sample C ETA pepsin (ng/mL)
	r	P value	r	P value	r	P value
Age on intubation (days)	-0.027	0.791	0.082	0.429	-0.170	0.164
Birth weight	0.010	0.919	0.155	0.132	-0.137	0.261
APGAR score at 1 minute	-0.082	0.426	0.027	0.795	0.008	0.951
APGAR score at 5 minutes	-0.020	0.847	-0.062	0.549	0.087	0.476
Proton pump inhibitor (days)	-0.004	0.981	0.054	0.748	-0.049	0.816
Prokinetic drugs (days)	0.005	0.976	-0.050	0.784	-0.230	0.259
Duration of MV (days)	0.080	0.438	0.130	0.208	-0.129	0.292
FiO2	0.166	0.104	0.203	0.047a	0.193	0.112
Amount of feeding (mL/day)	-0.210	0.039a	-0.234	0.022a	-0.267	0.027a
Duration of hospital stay (days)	0.031	0.766	0.288	0.004a	0.559	0.000a

^aP < 0.05.

Sample A was withdrawn immediately after intubation, Sample B was withdrawn 48 hours after intubation, Sample C was withdrawn immediately before extubation. ETA: Endotracheal aspirate; r: Pearson correlation coefficient; MV: Mechanical ventilation; APGAR: Appearance, Pulse, Grimace, Activity, Respiration.